Meprate

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What Is Meprate?

Meprate is a branded generic of medroxyprogesterone acetate (MPA) 10 mg, a synthetic 17-hydroxyprogesterone derivative with strong progestational activity. It binds the progesterone receptor and produces secretory transformation of an estrogen-primed endometrium — the basis for cycle regulation, withdrawal bleed induction, and endometrial protection during estrogen therapy. MPA also has weak androgenic and glucocorticoid activity, distinguishing it from bioidentical micronized progesterone (which is metabolically more inert).

Indikationer

• Secondary amenorrhoea — 5–10 mg/day for 5–10 days; withdrawal bleed follows discontinuation.
• Dysfunctional / abnormal uterine bleeding — 5–10 mg/day for 5–10 days starting on day 16–21 of the cycle.
• Endometriosis — 10 mg three times daily for 90 days, starting on day 1 of the cycle.
• HRT progestin opposition — 5–10 mg/day for 12–14 days each month (cyclic) or 2.5–5 mg/day continuous, alongside systemic estrogen, to prevent endometrial hyperplasia.
• Endometrial hyperplasia without atypia — 10–20 mg/day, with histological follow-up at 3–6 months.
• Adjuvant in advanced endometrial or renal-cell carcinoma — specialist-supervised higher doses.

How to Take Meprate

1. Take by mouth with or without food, at roughly the same time each day.
2. Withdrawal bleeding usually starts 3–7 days after the last tablet of a 5–10 day course.
3. For HRT, take alongside (not instead of) your estrogen component (oral, gel, or patch).
4. Pregnancy must be excluded before starting any course.

MPA vs Micronized Progesterone — Why It Matters

The Women’s Health Initiative (WHI) 2002 trial that raised concerns about combined HRT used conjugated equine estrogens + MPA — not bioidentical progesterone. Subsequent observational data (E3N, KEEPS) suggest micronized progesterone has a cleaner breast-cancer and cardiovascular signal. For postmenopausal HRT in 2024 practice, micronized progesterone (Susten / Endogest / Naturogest) is generally preferred. MPA remains useful and inexpensive for short courses (cycle regulation, withdrawal bleed, endometrial hyperplasia) where its strong endometrial transformation is the goal.

Biverkningar

Vanligt: breast tenderness, headache, mood changes, breakthrough bleeding, weight changes, fluid retention, acne, abdominal bloating.

Mindre vanliga: hirsutism (androgenic activity), reduced glucose tolerance, mild BP rise, depressive symptoms.

Serious (seek urgent care): sudden severe headache, vision changes, calf pain or swelling (VTE), chest pain, jaundice, breast lump.

Kontraindikationer

• Pregnancy or suspected pregnancy
• Undiagnosed vaginal bleeding
• Active or past breast cancer (relative; specialist call)
• Active VTE or stroke; recent MI
• Severe liver disease
• Known hypersensitivity to MPA

Läkemedelsinteraktioner

CYP3A4 inducers (rifampicin, carbamazepine, phenytoin, phenobarbital, St John’s wort) reduce MPA levels and may cause breakthrough bleeding or loss of effect. CYP3A4 inhibitors (azoles, macrolides, ritonavir, grapefruit) increase exposure. MPA may also reduce the effectiveness of some diabetes medications and slightly raise BP — monitor diabetic and hypertensive patients.

Pregnancy & Breastfeeding

Contraindicated in pregnancy. Discontinue if pregnancy is confirmed. Small amounts pass into breast milk; for short postpartum courses (e.g. lactation suppression context) discuss with a clinician. Bioidentical progesterone is preferred in luteal support and IVF settings.

Förvaring

Store below 25 °C in the original blister. Keep out of the reach of children.

Vanliga frågor

Is Meprate the same as natural progesterone?

No. Meprate is a synthetic progestin (medroxyprogesterone acetate) with strong endometrial activity but also weak androgenic and glucocorticoid effects. Natural micronized progesterone (Susten / Endogest / Naturogest) is bioidentical, has a cleaner side-effect profile, and is generally preferred for postmenopausal HRT.

How long until withdrawal bleeding starts after a 5–10 day course?

Bleeding typically starts 3–7 days after the last tablet, lasting 3–5 days. If you do not bleed within two weeks of stopping, exclude pregnancy and review with your clinician.

Can Meprate be used as a contraceptive?

Oral MPA at this dose is inte a reliable contraceptive. Depot MPA (medroxyprogesterone acetate 150 mg IM every 12 weeks — Depo-Provera) is contraceptive but is a different product. Use a non-hormonal contraceptive while taking oral MPA if pregnancy must be avoided.

Can I take Meprate with my estrogen patch / gel for HRT?

Yes — that is the standard combined HRT regimen for women with a uterus. Meprate provides progestin opposition to prevent estrogen-driven endometrial hyperplasia. Cyclic (12–14 days/month) gives a withdrawal bleed; continuous low-dose gives no scheduled bleeding once the endometrium becomes atrophic.

Will Meprate cause weight gain?

Modest weight changes (1–2 kg) are reported, often water-related. The androgenic activity of MPA is more likely to drive metabolic side effects than micronized progesterone.

Vad händer om jag missar en dos?

Take it as soon as you remember unless it is close to the next scheduled dose — do not double up. Missed doses can trigger breakthrough bleeding.

Can Meprate cause depression?

Synthetic progestins, including MPA, can worsen low mood in susceptible women. If you notice mood changes, switch to bioidentical progesterone or discuss alternatives with your clinician.

Is Meprate safe with breast cancer history?

No. A personal history of hormone-sensitive breast cancer is a contraindication. Specialist input is required for any progestin in this setting.

Can men take Meprate?

Off-label use exists for paraphilic disorders and prostate cancer adjuvant therapy under specialist supervision — not appropriate for self-administration.

What is the difference between Meprate, Provera, and Cycrin?

All three are MPA 10 mg branded generics. Meprate is the Indian brand (Mankind Pharma). Provera (Pfizer) is the original US brand. The molecule and dose are identical.

Other Hormone & Women’s Health Medications

Andra produkter inom HRT & Women’s Health som kunder även tittar på:

• Susten Capsule (Micronized Progesterone 100 mg)
• Endogest (Micronized Progesterone 100 mg)
• Naturogest (Micronized Progesterone)
• Progynova (Estradiol Valerate)
• Oestrogel Gel (Estradiol Transdermal)

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