Seretide Evohaler

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What Is Seretide Evohaler?

Seretide Evohaler is an Indian-manufactured pressurised metered-dose inhaler (HFA pMDI) combining fluticasone propionate + salmeterol. The international brand of this combination is Seretide. Combination ICS-LABA inhalers deliver superior asthma and COPD control compared to either component alone, with a single device improving adherence and reducing the risk of using LABA monotherapy (which carries a black-box warning for asthma death without concomitant ICS).

How Does Seretide Evohaler Work?

The two active ingredients work on different mechanisms in parallel:

• fluticasone propionate (inhaled corticosteroid): suppresses inflammatory cytokines, reduces eosinophil and lymphocyte infiltration, stabilises airway mucosa, restores β2 receptor responsiveness. Effect builds over 1–2 weeks of consistent dosing.
• salmeterol (long-acting β2 agonist): activates bronchial smooth muscle β2 receptors, raising cyclic AMP and producing sustained bronchodilation lasting 12 hours (formoterol has 1–3 minute onset; salmeterol 15–30 minute onset).
• Synergy: the corticosteroid restores β2 receptor expression and prevents tachyphylaxis to LABA; the LABA improves smooth-muscle relaxation that ICS alone does not address. Combined, they reduce exacerbations more than either component alone at equivalent doses.

Användningsområden och indikationer

• Persistent asthma not controlled by ICS alone — first-line ICS-LABA combination
• Asthma maintenance therapy — twice daily, every day, regardless of symptoms
• COPD with frequent exacerbations, especially with elevated blood eosinophil count (≥300/µL) or asthma overlap
• Asthma-COPD overlap syndrome (ACOS)
• Step-up from ICS monotherapy when symptoms or exacerbations persist

Seretide Evohaler Dosage

How to Use Seretide Evohaler Properly

• Shake the inhaler well; remove the cap.
• Breathe out fully away from the device.
• Seal lips around the mouthpiece.
• Press the canister at the start of a slow deep breath (3–5 seconds).
• Hold breath 10 seconds, then breathe out gently.
• Wait 30 seconds before second puff if needed.
• Rinse mouth, gargle, and spit out after every dose.
• Use a spacer for children, the elderly, and during acute illness.

Side Effects of Seretide Evohaler

Common (mostly local from ICS, plus some β2 effects from LABA):

• Oral thrush (white candidal plaques in mouth or throat)
• Hoarse voice / dysphonia
• Mild tremor (LABA effect; less than with high-dose SABA)
• Palpitations or heart rate increase (≤10 bpm at standard dose)
• Huvudvärk
• Throat irritation, mild cough on inhalation

Mindre vanliga:

• Mild reduction in growth velocity in children at high doses
• Easy bruising at high cumulative ICS doses
• Hypokalaemia at high LABA doses (with diuretics, theophylline, oral steroids)
• Pneumonia in COPD users (slight ICS-related increase)
• Adrenal suppression with high doses or strong CYP3A4 inhibitor co-prescription

Serious (stop and seek emergency help):

• Severe allergic reaction / anaphylaxis
• Paradoxical bronchospasm
• Severe palpitations, chest pain, irregular heartbeat
• Adrenal crisis during illness or surgery

Varningar och försiktighetsåtgärder

• Use every day, even when you feel well. The benefit accumulates over 1–2 weeks; symptoms return within days of stopping.
• Never use the LABA component alone in asthma — LABA without ICS carries a higher risk of severe asthma death. {$brand} contains both components, so this is not an issue with this product.
• {$brand} is not a rescue inhaler (use Asthalin or Levolin for acute attacks).
• Rinse mouth, gargle, and spit out after every dose; brush teeth before bed.
• COPD users: ICS slightly raises pneumonia risk — ensure ICS adds value (eosinophilic phenotype, frequent exacerbations).
• Strong CYP3A4 inhibitors (ritonavir, ketoconazole, itraconazole, clarithromycin) raise systemic exposure of both components — avoid prolonged co-prescription.
• Graviditet och amning: Budesonide-formoterol has the most pregnancy data; uncontrolled asthma is far more dangerous than the medication.
• Cardiovascular disease: use cautiously in severe coronary artery disease, arrhythmias, hyperthyroidism, severe heart failure.

Contraindications

• Known hypersensitivity to fluticasone propionate, salmeterol, or any formulation excipient
• Untreated active fungal, bacterial, mycobacterial (TB), or viral respiratory infection
• Severe hypersensitivity to lactose or milk proteins (DPI formulations contain lactose)
• Acute asthma attack — use a SABA reliever instead

Läkemedelsinteraktioner

Förvaring

• Store below 25°C, protected from direct sunlight and heat.
• Do not refrigerate. Do not freeze.
• Do not puncture the canister; even an empty canister can explode if heated.
• Keep out of reach of children. Use within the expiry date printed on the canister.

Relaterade alternativ på MedsBase

• Budecort Inhaler — budesonide ICS preventer
• Asthalin Inhaler — salbutamol reliever
• Tiova Inhaler — tiotropium LAMA for COPD
• Montair — montelukast LTRA add-on
• Duolin Inhaler — salbutamol + ipratropium combo reliever

Vanliga frågor

Is Seroflo the same as Seretide or Advair?

Yes — all three contain fluticasone propionate + salmeterol. Seretide (GSK, EU/UK), Advair (GSK, US), Seroflo (Cipla, India). Clinically interchangeable at equivalent strength pairs.

Why is Seroflo a preventer and not a rescue inhaler?

The salmeterol component has slow onset (15–30 minutes) — it does not relieve acute breathlessness. For acute attacks, use a separate SABA reliever (Asthalin, Levolin). Take Seroflo every day to prevent attacks.

How long until Seroflo starts to work?

Some lung function gain by day 1; symptom improvement by week 1; full preventer effect by 2–4 weeks of consistent twice-daily use.

Why must I rinse my mouth after Seroflo?

Local steroid deposition can cause oral thrush and hoarseness. Rinsing, gargling, and spitting after every dose largely prevents both.

Can children use Seroflo?

Yes from age 4 — typically at 50/25 or 100/25 strength via inhaler with spacer + mask. Higher strengths reserved for older children and adults.

Is Seroflo safe in pregnancy?

Fluticasone has reassuring observational data in pregnancy. Budesonide-formoterol (Foracort) has more data; some prescribers prefer that combination during pregnancy. Uncontrolled asthma is more dangerous than either drug.

Can I use Seroflo as a SMART/MART reliever?

No — salmeterol has slow onset and is not licensed for as-needed use. Only formoterol-containing combinations (Foracort, Symbicort) can be used as SMART/MART.

How long does a Seroflo Inhaler last?

A 120-actuation canister lasts 60 days at twice-daily dosing. Rotacaps come in blister packs; check the leaflet for actuations per pack.

What’s the difference between Seroflo Inhaler, Rotacaps, Multihaler, Autohaler, Accuhaler?

All deliver fluticasone + salmeterol but use different devices and dose strengths. Inhaler = pressurised aerosol with spacer-friendly dosing. Rotacaps = single-dose dry powder via Rotahaler. Multihaler = multi-dose dry powder. Autohaler = breath-activated MDI (no need to coordinate). Accuhaler = multi-dose blister-strip dry powder. Choose based on your inspiratory ability and coordination.

More options in Asthma/COPD Treatment

Rangerade efter senaste ordervolym på MedsBase — vad andra kunder i denna kategori väljer.

Asthalin

US$2.00 – US$8.00Interval de preț: US$2.00 până la US$8.00

Aerocort Inhaler

US$6.00 – US$14.00Interval de preț: US$6.00 până la US$14.00

Asthalin Respules

US$10.90 – US$27.50Interval de preț: US$10.90 până la US$27.50