Endoxan
✅ Treats various cancers
✅ Suppresses immune system
✅ Controls autoimmune diseases
✅ Csökkenti a gyulladást
✅ Manages nephrotic syndrome
Endoxan contains Cyclophosphamide.
✓ Orvosi ellenőrzés Morgan Ellis — Gyógyszerkutató · 8 év tapasztalat · Utolsó felülvizsgálat: 2026 május
⚡ Quick Answer — What is Endoxan?
Endoxan is an oral tablet from Baxter containing cyclophosphamide 50 mg — an alkylating cytotoxic agent (nitrogen mustard derivative) used for haematological malignancies, breast cancer (CMF / AC regimens), severe autoimmune disease (lupus nephritis, ANCA vasculitis), and bone marrow conditioning. Standard low-dose oral regimens: 1–3 mg/kg/day or pulsed weekly cycles, prescribed by specialist. Mandatory monitoring: FBC every 1–2 weeks, urine for haemorrhagic cystitis, fertility preservation discussion before starting. Plenty of fluids (3 L/day during active dosing) to flush bladder and prevent haemorrhagic cystitis from acrolein metabolite. Pregnancy contraindication; gonadotoxic with permanent infertility risk — offer fertility preservation in reproductive-age patients.
📦 Minden rendelést fedez a Újraküldési Garancia — ha a csomagod nem érkezik meg 20 munkanapon belül, újraküldjük.
What Is Endoxan?
Endoxan is an oral tablet from Baxter containing cyclophosphamide 50 mg. Cyclophosphamide is a prodrug alkylating cytotoxic agent (nitrogen mustard family). It is metabolised in the liver to active 4-hydroxycyclophosphamide and the toxic metabolite acrolein. Used in many haematological cancers, solid tumours and severe autoimmune diseases.
Felhasználás és indikációk
- Hematológiai: chronic lymphocytic leukaemia, low-grade non-Hodgkin lymphoma, multiple myeloma, Waldenström macroglobulinaemia, conditioning before stem cell transplant
- Solid tumours: breast cancer (CMF, AC regimens), small-cell lung cancer, ovarian cancer, neuroblastoma, sarcoma (high-dose IV)
- Severe autoimmune disease: lupus nephritis, ANCA-associated vasculitis (granulomatosis with polyangiitis, microscopic polyangiitis), refractory rheumatoid arthritis
- Off-label alkalmazás: nephrotic syndrome (steroid-resistant), pemphigus vulgaris
Adagolás és szedés módja
Oral regimens vary by indication; specialist prescribing only. Examples for adults:
- Low-dose continuous oral: 1–3 mg/kg/day
- Pulsed oral cyclophosphamide for vasculitis: 50–200 mg/day
- Take in the morning with plenty of fluid — aim for at least 3 L of fluid intake per day during active dosing to flush the bladder of acrolein and reduce haemorrhagic cystitis risk.
- Empty bladder frequently. Consider mesna prophylaxis at higher cumulative dose under specialist guidance.
- Take with food if nausea occurs. Antiemetic (ondansetron) 1 hour before if needed.
- Swallow tablets whole. Do NOT crush. Caregivers handling tablets should wash hands.
- Kötelező monitorozás: FBC every 1–2 weeks; urinalysis monthly (haematuria); LFTs monthly; baseline + ongoing renal function.
- Fertility preservation: discuss before starting in reproductive-age patients. Cyclophosphamide is gonadotoxic — sperm banking, oocyte / embryo cryopreservation, or GnRH-agonist ovarian protection should be offered.
Mellékhatások
Gyakori: nausea, vomiting (preventable with antiemetics), alopecia, anorexia, mucositis, fatigue.
Fontos:
- Mieloszuppresszió — nadir at 7–10 days; full recovery by day 21
- Haemorrhagic cystitis — from acrolein bladder toxicity; prevent with high fluid intake (3 L/day) and frequent bladder emptying; mesna for high-dose regimens
- Permanent infertility — gonadotoxic; sperm banking and oocyte preservation should be offered before starting in reproductive-age patients
- Bladder cancer (long-term, dose-related)
- Secondary leukaemia / myelodysplastic syndrome
- Cardiotoxicity (mostly high-dose IV regimens)
- Pulmonary fibrosis (rare)
- SIADH and water intoxication (high-dose IV)
Figyelmeztetések
- Terhesség: teratogenic and abortifacient. Strict contraception throughout treatment + 12 months after for women, 6 months for men.
- Szoptatás: Ellenjavallt.
- Severe hepatic or renal impairment: reduce dose, specialist guidance.
- Élő oltóanyagok: Ellenjavallt.
- Active urinary tract infection: treat before starting.
- Caregivers: wear gloves when handling tablets or contaminated body fluids; wash exposed skin immediately.
Gyógyszerkölcsönhatások
| Kombinálható | Hatás | Teendők |
|---|---|---|
| Allopurinol | Raises cyclophosphamide marrow toxicity | Monitor FBC closely. |
| Varfarin | INR variability | Monitor INR weekly. |
| Élő oltóanyagok | Széleskörű fertőzés | Ellenjavallt. |
| Other immunosuppressants | Additive infection risk | Szakorvosi felügyelet. |
| CYP3A4 inhibitors / inducers | Modify activation of cyclophosphamide prodrug | Szakorvosi vélemény. |
Tárolás
- Szobahőmérsékleten, 15–25°C között, eredeti blistercsomagolásban.
- Gyermekek, gyermekvállalásra képes nők és háziállatok elől elérhetetlen helyen.
- Caregivers wear gloves when handling.
Kapcsolódó alternatívák a MedsBase-en
További onkológiai gyógyszerek, amelyek e termék mellett elérhetők:
- Celkeran (chlorambucil 2 / 5 mg)
- Temotero (temozolomid 20 / 100 mg)
- Temozol (temozolomid 20 mg)
- Lomoother (lomusztin 40 mg)
- Endace (megesztrol 40 / 160 mg)
Összes rákkel szembeni gyógyszer böngészése →
Gyakran Ismételt Kérdések
Why do I need so much fluid on Endoxan?
Cyclophosphamide produces a toxic metabolite called acrolein that concentrates in the bladder and causes haemorrhagic cystitis — bleeding from the bladder wall. Aggressive hydration (at least 3 L of fluid per day during active dosing) flushes acrolein out before it damages the bladder. Empty your bladder frequently and avoid holding urine overnight if possible. For higher-dose regimens, mesna (a thiol drug that neutralises acrolein) is prescribed.
Will Endoxan make me infertile?
Yes — cyclophosphamide is gonadotoxic and may cause permanent infertility, especially with cumulative doses > 5–7 g/m² and in older reproductive-age patients. Fertility preservation should be offered before starting in any reproductive-age patient: sperm banking (men), oocyte or embryo cryopreservation (women), or GnRH-agonist ovarian protection during treatment. Discuss with the oncologist before the first dose.
Milyen vérvizsgálatokra van szükségem?
Mandatory: FBC every 1–2 weeks (nadir at days 7–10, recovery by day 21); urinalysis monthly (haematuria detection); LFTs monthly; baseline + ongoing renal function. Inform your specialist of any blood in urine, fever, mouth ulcers, or unusual bleeding.
Why is bladder cancer a long-term risk?
Long-term cyclophosphamide exposure increases bladder cancer risk, dose-related and cumulative-dose-related. After a course of cyclophosphamide, regular urinalysis (at least annually) for haematuria is reasonable; cystoscopy if persistent haematuria. Stop smoking — smoking compounds the bladder cancer risk dramatically.
Can I get pregnant on Endoxan?
No — cyclophosphamide is teratogenic and abortifacient. Reliable contraception throughout treatment AND for at least 12 months after the last dose (women) or 6 months (men). Discuss family planning with your specialist; consider fertility preservation before starting.
Kaphatok élő oltóanyagot?
No — live vaccines (MMR, yellow fever, BCG, oral polio, varicella) contraindicated during cyclophosphamide and for 3–6 months after stopping. Inactivated vaccines (annual flu, pneumococcal, COVID-19) are not only safe but recommended.
What infections should I watch for?
Cyclophosphamide-induced lymphopenia raises risk of opportunistic infections. Seek same-day care for any fever > 38°C, persistent cough, breathlessness, severe diarrhoea, or new rash. PCP prophylaxis (co-trimoxazole) may be prescribed at higher doses or in transplant settings.
Caregivers handling Endoxan — any precautions?
Yes — cyclophosphamide tablets and patient body fluids (urine, vomit) for the first 48 hours after a dose contain cytotoxic compounds. Caregivers should wear gloves when handling tablets, contaminated linen, or body fluids; wash hands afterwards; double-flush the toilet. Pregnant caregivers should avoid handling cyclophosphamide entirely.
Miért rendelj a MedsBase-ról
Minden tétel egy WHO-GMP tanúsított gyártó. WHO-GMP Újraküldési Garancia: ha egy csomag nem érkezik meg 20 munkanapon belül, ingyenes utánküldést biztosítunk, kérdések nélkül.
Kapcsolódó rákellenes gyógyszerek
További onkológiai gyógyszerek, amelyek e termék mellett elérhetők:
- Celkeran (chlorambucil 2 mg)
- Lomoother (lomusztin 40 mg)
- Folitrax (metotrexát 2,5/7,5/10 mg)
- Imutrex (metotrexát 2,5/7,5/10 mg)
- Hydrosar (hidroxiurea 500 mg)
További lehetőségek az Antirákos Gyógyszerek között
Rangsorolva a MedsBase legutóbbi rendelési adatai alapján — hogy ebben a kategóriában más vásárlók mit választanak.
| Erősség | 50 mg |
|---|---|
| Mennyiség | 30 tabletta, 60 tabletta, 90 tabletta, 180 tabletta |
Endoxan
Kérdések és válaszok
Endoxan
Kapcsolódó termékek
Vélemények
Még nincsenek vélemények