Trazonil

✅ Eases depression symptoms
✅ Enhances sleep quality
✅ Alleviates anxiety
✅ Manages PTSD
✅ Reduces side effects

Trazonil contains Trazodone Hydrochloride.

SKU: N/A Kategória: Kategória áttekintése, Krónikus betegségek, Helyzeti szorongás kezelése Címke: Trazodone, Trazonil

✓ Orvosi ellenőrzés Morgan Ellis — Gyógyszerkutató · 8 év tapasztalat · Utolsó felülvizsgálat: 2026 május

Több vásárlás, több megtakarítás Ár tablettánként

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Titkosított fizetés

Kriptovaluta fizetés 10% kedvezmény

Diszkrét világszerte szállítás

1 400+ vásárló · 50+ ország

Erősség

25 mg
50 mg
100 mg

Mennyiség

30 tabletta
60 Tablet/s
90 tabletta
180 tabletta

Törlés

⚡ Quick Answer — What is Trazonil?

Trazonil tartalmaz trazodone hydrochloride (50 mg / 100 mg) from a WHO-GMP certified manufacturer (Intas Pharmaceuticals) — a SARI antidepressant whose primary modern use is insomnia at low dose (25–100 mg at bedtime) rather than depression. Mechanism: 5-HT_2A antagonism plus weak SRI plus alpha-1 antagonism plus H₁ antagonism — the 5-HT_2A/H₁/alpha-1 combination drives sedation. Antidepressant doses (150–400 mg/day) are uncommon today — SSRIs and SNRIs largely replaced trazodone for MDD. Off-label insomnia is its dominant use. Important warnings: priapism (rare, 1 in 1,000–10,000 — emergency if > 4 h), orthostatic hypotension (alpha-1), QT prolongation at high doses. Very safe in overdose compared to TCAs.

Mit kapsz a MedsBase-nál: WHO-GMP minősítésű gyártó · Diszkrét csomagolás · Világszerte szállítás · 1.400+ hitelesített vásárlói vélemény

📦 Minden rendelést fedez a Újraküldési Garancia — ha a csomagod nem érkezik meg 20 munkanapon belül, újraküldjük.

Miért rendelj a MedsBase-ról

Generikus gyógyszereink WHO-GMP minősítésű gyártóktól származnak, és diszkrét, egyszerű csomagolásban szállítjuk őket világszerte — a csomagon nem szerepel a gyógyszer neve. A kártyás fizetések egy szabályozott feldolgozón keresztül történnek (a számlaleírások egy szabályozott kártyafizetési feldolgozót tartalmaznak — soha nem “MedsBase” vagy bármilyen gyógyszer neve). Kriptovalutát és SEPA banki átutalást is elfogadunk. Minden rendelést a Reshipment Assurance Policy biztosíték fedez.

Important — this is not a situational-anxiety medication. Trazonil is a serotonin antagonist and reuptake inhibitor (SARI), prescribed and titrated over weeks for major depressive disorder (MDD); off-label widely used at low dose for chronic insomnia. It is nem the right drug for acute, performance-related anxiety (flying, public speaking, exams) — for those use cases beta-blockers (propranolol), benzodiazepines, or hydroxyzine are clinically appropriate. If you do not have a diagnosed mood, anxiety, or psychiatric disorder, do not start this medication.

FDA black-box warning — suicidality. All antidepressants carry an FDA black-box warning for increased risk of suicidal thinking and behaviour in children, adolescents, and young adults under 25, particularly during the first weeks of treatment or after dose changes. Family members and prescribers should monitor closely for worsening mood, agitation, or suicidal ideation in this age group.

What Is Trazonil?

Trazonil is an oral tablet of trazodone hydrochloride (50 mg / 100 mg) manufactured by Intas Pharmaceuticals. Trazodone (US brand Desyrel) is a serotonin antagonist and reuptake inhibitor (SARI) introduced in 1981. It blocks 5-HT_2A receptors potently, weakly inhibits the serotonin transporter, and antagonises alpha-1 adrenergic and H₁ histamine receptors. The combination is heavily sedating — which is why trazodone has become predominantly an off-label hypnotic rather than an antidepressant in modern practice.

Indikációk

Nagy depressziós zavar — on-label, but uncommon today (SSRIs / SNRIs are first-line)
Insomnia (off-label, low-dose) — the most common modern use; 25–100 mg at bedtime
Off-label adjuncts: SSRI-induced insomnia, anxiety with insomnia, agitation in dementia (used with caution)

Adagolás

Agoprex is a 25 mg agomelatine tablet supplied by Sun Pharma. Agomelatine is mechanistically unique among antidepressants: it acts as an agonist at melatonin MT1 and MT2 receptors and an antagonist at 5-HT2C serotonin receptors. The dual mechanism resynchronises disrupted circadian rhythms (a feature of major depression) while indirectly increasing dopamine and noradrenaline release in the frontal cortex.	Kezelés indítása	Typical	Maximális	Megjegyzések
Insomnia (off-label)	25–50 mg at bedtime	50–100 mg at bedtime	150 mg lefekvés előtt	Most commonly used dose range; effective hypnotic without significant antidepressant action
MDD (on-label)	50–75 mg/day in divided doses	150–400 mg/day	600 mg/day inpatient	Daytime divided doses for antidepressant effect; sedation often prohibitive
Elderly insomnia	25 mg at bedtime	25–50 mg at bedtime	100 mg	Caution — orthostasis and falls
Májkárosodás	Reduce by 25–50%	—	—	Lassabb dózisemelés

Mellékhatások

Side-effect profile

Gyakoriság	Hatás	Megjegyzések
Gyakori	Sedation, drowsiness	The point of off-label hypnotic use; problematic for daytime dosing
Gyakori	Orthosztatikus hypotónia, szédülés	Alpha-1 blockade — falls risk in elderly
Gyakori	Dry mouth, blurred vision	Mild anticholinergic
Gyakori	Hányinger, hányás	Étellel bevenni
Kevesebb gyakoriságú	Headache, nasal congestion	Alpha-1 blockade
Kevesebb gyakoriságú	Weight gain (modest)	Less than mirtazapine or paroxetine
Ritka	Priapism (1 in 1,000–10,000)	Persistent erection > 4 h is a urological emergency — mechanism is alpha-1 blockade interfering with detumescence; men should be counselled and report immediately
Ritka	QT-intervallum meghosszabbodás	Dose-related; caution with other QT-prolonging drugs
Ritka	Szerotonin szindróma	See interactions

Gyógyszerkölcsönhatások

Absolute contraindications: MAOIs (14-day washout).

Additive sedation: alcohol, benzodiazepines, opioids, antihistamines, sedating antipsychotics — main interaction concern in older adults.

QT-intervallum meghosszabbodás: caution with citalopram (high dose), ondansetron, methadone, fluoroquinolones.

CYP3A4 substrate: levels rise with strong inhibitors (ketoconazole, ritonavir, clarithromycin) — reduce dose or avoid.

Antihipertenzív szerek: additive orthostasis with alpha-blockers, doxazosin, prazosin, terazosin.

Why Trazodone for Insomnia?

Trazodone has become the most-prescribed off-label sleep medication in many countries despite very thin formal sleep-disorder evidence. The reasons are pragmatic:

Heavy sedation at low dose (25–100 mg)
No physiological dependence or rebound insomnia (unlike benzodiazepines / Z-drugs)
No DEA scheduling
Low overdose toxicity
Generic and inexpensive
Useful when SSRI-induced insomnia complicates depression treatment

Limitations: orthostatic falls (especially in older adults), priapism risk in men, and limited objective data on sleep-architecture preservation. Daytime grogginess can persist with low-dose 100 mg use.

Gyakran Ismételt Kérdések

How long does Trazonil take to work for sleep?

Sedation begins within 1–2 hours of taking the dose. Take 30 minutes before intended bedtime.

Will Trazonil help with depression at low dose?

No — antidepressant effect requires 150–400 mg/day in divided doses. Bedtime 25–100 mg is purely a hypnotic dose.

Is Trazonil safer than zolpidem (Ambien) or benzodiazepines for sleep?

Different risk profile. Trazodone has no dependence potential and far lower overdose risk, but more orthostasis, falls, priapism (rare), and daytime grogginess. The right choice depends on patient age, fall risk, sex (priapism in men), and history of substance use.

What is priapism and how worried should I be?

Priapism is a persistent erection unrelieved by ejaculation, usually painful, lasting more than 4 hours. It is a urological emergency — without prompt treatment, permanent erectile dysfunction can result. Trazodone-related priapism is rare (1 in 1,000–10,000) but real. Men starting trazodone should be told to seek emergency care for any erection lasting more than 4 hours.

Can I drink alcohol on Trazonil?

Avoid — additive sedation and orthostasis. Combining trazodone with alcohol significantly increases sedation and fall risk.

Does Trazonil cause sexual dysfunction?

Less than SSRIs. Mechanism is different — the 5-HT_2A blockade does not cause SSRI-style sexual side effects. Priapism in men is the rare specific concern.

Can I stop Trazonil abruptly?

Better to taper, but discontinuation syndrome is much milder than SSRIs / SNRIs. Tapering over 1–2 weeks is usually sufficient.

Is Trazonil safe in pregnancy?

Limited data — not first-line. Discuss individually with the prescriber.

Can Trazonil cause weight gain?

Modest weight gain over months — less than mirtazapine, paroxetine, or olanzapine. Not a major concern at hypnotic doses.

How should Trazonil be stored?

Store at 15–30 °C in the original blister packaging away from moisture and sunlight. Keep out of reach of children — trazodone is much safer in overdose than TCAs but still medically significant.

Orvosi felelősségi nyilatkozat: Information on this page is intended for adults using prescribed psychiatric medication and is not a substitute for individualised medical care. Antidepressants, antipsychotics, and related medications can interact with other drugs, alcohol, and pre-existing conditions. Discuss any new medication, dose change, or planned discontinuation with a qualified prescriber. If you experience suicidal thoughts, mania, severe akathisia, signs of serotonin syndrome (high fever, confusion, muscle rigidity, rapid heart rate), or neuroleptic malignant syndrome, seek emergency care immediately.