Honvan
Honvan (Fosfestrol 120 mg) — high-dose diethylstilbestrol diphosphate oestrogen for advanced metastatic prostate cancer. Significant cardiovascular and thrombotic risk.
✓ Medisinsk vurdert av Morgan Ellis — Farmasøytisk forsker · 8 års erfaring · Sist gjennomgått: mai 2026
Kort svar
Honvan — Fosfestrol Tetrasodium 120 mg (Asta Medica). Diethylstilbestrol diphosphate — high-dose estrogen for advanced metastatic prostate cancer. Largely replaced by LHRH agonists; remains in resource-limited or palliative settings.
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⚠️ Specialist-supervised cancer therapy — this medication is started, monitored, and stopped by an oncologist or haematologist. Dosing depends on tumour type, stage, body surface area, organ function, and concomitant therapy. Self-treatment is not appropriate; the information below is educational and supports informed conversations with your specialist.
Fosfestrol carries substantial cardiovascular risk — DVT, PE, MI, stroke, fluid retention. Use only when modern alternatives (LHRH agonists, abiraterone, enzalutamide) are unavailable or unsuitable. Mandatory thromboprophylaxis discussion with cardiology.
Vanlige spørsmål
When is this used?
Diethylstilbestrol diphosphate — high-dose estrogen for advanced metastatic prostate cancer. Largely replaced by LHRH agonists; remains in resource-limited or palliative settings.
Side effects to watch?
Hot flushes, gynaecomastia, fatigue, sexual dysfunction (anti-androgen class effect). Drug-specific monitoring as outlined in the safety boxes above.
Legemiddelinteraksjoner?
Vary by molecule — abiraterone is CYP3A4 substrate; bicalutamide is CYP3A4 substrate. Always disclose all medications. Strong CYP3A4 inhibitors/inducers significantly affect levels.
Når bør det stoppes?
On disease progression, intolerable toxicity, or successful response with planned treatment break. Always specialist-decided — abrupt cessation can result in transient PSA rise (withdrawal response) which is generally not concerning.
PSA-overvåkning?
PSA every 1-3 months while on therapy. Rising PSA on castration suggests castration-resistance — may need switch to second-line agents (abiraterone, enzalutamide, docetaxel).
Combined androgen blockade?
LHRH agonist (goserelin, leuprolide) + bicalutamide is a common combination. Maximal androgen blockade has modest survival benefit over LHRH alone.
Bone health?
Long-term androgen deprivation accelerates bone loss. Add a bisphosphonate (zoledronic acid) or denosumab in osteopenia/osteoporosis. Calcium and vitamin D supplementation.
Graviditet?
Anti-androgens are teratogenic — partners must use effective contraception during therapy. Most relevant for younger men with localised disease.
Hva om jeg glemmer en dose?
Take when you remember if same day; otherwise skip. Specialist may have specific guidance for missed doses depending on regimen.
Cardiovascular monitoring?
Mandatory for fosfestrol; advised for abiraterone (BP, fluid retention, electrolytes); routine for bicalutamide (occasional CV review).
Other Cancer & Anti-Androgen Therapy
- Calutide — bicalutamide 50 mg — alternative anti-androgen brand
- Xbira — abiraterone 250 mg — CYP17 inhibitor for mCRPC
- Honvan — fosfestrol 120 mg — diethylstilbestrol diphosphate
- Estramustine — estramustine phosphate — alkylator for hormone-refractory disease
- Zoldria — zoledronic acid IV for bone metastases
More options in Anti Cancer Medication
Rangert etter nylig bestillingsvolum på MedsBase — hva andre kunder i denne kategorien velger.
| Styrke | 120 mg |
|---|---|
| Antall | 30 Tablett/er, 60 Tablett/er, 90 Tablett/er |
| Farmasøytisk form | Tablet/t |
| Produsent | Zydus Pharma |
| Behandling | Prostate Cancer |
| Generisk merke | Fosfestrol Tetrasodium |
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