Xeloda
Xeloda (Capecitabine 500 mg) — Roche oral 5-FU prodrug for breast, colorectal, gastric, and pancreatic cancer. Twice-daily 14-day-on/7-day-off cycles with hand-foot syndrome management.
✓ Medisinsk vurdert av Morgan Ellis — Farmasøytisk forsker · 8 års erfaring · Sist gjennomgått: mai 2026
Kort svar
Xeloda — capecitabine 500 mg (Roche). Oral 5-fluorouracil (5-FU) prodrug — for adjuvant and metastatic colorectal cancer, breast cancer, gastric cancer, and pancreatic cancer. Bypass IV access. Twice-daily oral schedule.
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Hvorfor bestille fra MedsBase
Xeloda ships from a WHO-GMP certified manufacturer in plain packaging, billed through a regulated payment processor (the statement descriptor reads a regulated card-payment processor — never MedsBase or any medication name). Every order carries our 20-business-day Reshipment Assurance.
⚠️ Specialist-supervised cancer therapy — this medication is started, monitored, and stopped by an oncologist or haematologist. Dosing depends on tumour type, stage, body surface area, organ function, and concomitant therapy. Self-treatment is not appropriate; the information below is educational and supports informed conversations with your specialist.
Common (30-60%) and dose-limiting. Symptoms: tingling, redness, painful fissures, peeling on palms/soles. Grade 2+ requires dose interruption + reduction. Prophylaxis: emollients, gloves for housework, avoid heat exposure, urea-based creams, vitamin B6 of unproven benefit. Reassess at every cycle.
Dihydropyrimidine dehydrogenase (DPD) deficiency causes severe, sometimes fatal toxicity — neutropenia, mucositis, diarrhoea, neuropathy. Some guidelines now recommend DPYD genotype testing before starting any 5-FU or capecitabine to identify partial/complete deficiency. If DPD-deficient, dose reduction or alternative therapy is needed.
Vanlige spørsmål
How is it taken?
1250 mg/m² twice daily for 14 days, followed by a 7-day rest (3-week cycle). Some regimens use 1000 mg/m² BID × 14 days. Always specialist-prescribed by body surface area.
With or without food?
Within 30 minutes after a meal — improves tolerability and standardises absorption.
Common side effects?
Hand-foot syndrome (very common), diarrhoea, nausea, fatigue, mucositis, hyperbilirubinaemia, mild neutropenia. Severe in DPD-deficient patients.
Legemiddelinteraksjoner?
Warfarin: capecitabine massively raises INR — frequent monitoring or switch to LMWH. Phenytoin: raised levels. Folinic acid: can enhance toxicity in some regimens. CYP2C9 substrates: variable interactions.
Contraindications?
Severe renal impairment (CrCl <30), severe DPD deficiency, pregnancy, breastfeeding. Caution in moderate renal impairment (dose reduce 25%).
What if hand-foot syndrome develops?
Grade 1 (mild redness/dysaesthesia): continue with topical care. Grade 2 (painful, interfering with function): pause until grade 1, reduce dose 25%. Grade 3 (severe): pause, reduce 50% on resuming.
Graviditet?
Strongly contraindicated — teratogenic. Effective contraception during and for at least 6 months after.
Renal monitoring?
Baseline renal function then before each cycle. Dose-adjust for CrCl 30-50 mL/min. Avoid for CrCl <30.
Vs IV 5-FU?
Equivalent or superior efficacy in most settings (X-ACT trial in colorectal). Oral administration is much more convenient and avoids central line complications.
Hva om jeg glemmer en dose?
Skip the missed dose if >6 hours late. Do not double up. Discuss with your oncology team if multiple doses missed.
Other Cancer Medications
- Xeloda — capecitabine 500 mg — oral 5-FU prodrug for breast/colorectal/gastric cancers
- Altraz — anastrozole 1 mg — aromatase inhibitor for post-menopausal breast cancer
- Xbira — abiraterone 250 mg — CYP17 inhibitor for metastatic prostate cancer
- Zoldria — zoledronic acid IV — for bone metastases and hypercalcaemia
- Actorise — darbepoetin alfa — for chemotherapy-induced anaemia
More options in Anti Cancer Medication
Rangert etter nylig bestillingsvolum på MedsBase — hva andre kunder i denne kategorien velger.
| Styrke | 500 mg |
|---|---|
| Antall | 30 Tablett/er, 60 Tablett/er, 90 Tablett/er |
| Farmasøytisk form | Tablet/t |
| Produsent | Roche Pharma |
| Behandling | Ovarian cancer, Head and neck cancer, Cervical cancer |
| Generisk merke | Capecitabine |
Xeloda
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Xeloda
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