Arachitol 6L Injection
✅ Promotes bone health
✅ Regulates calcium absorption
✅ Supports immune function
✅ Helps prevent osteoporosis
✅ Enhances muscle strength
Arachitol 6L Injection contains Vitamin D3.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
Quick Answer
Arachitol 6L Injection (cholecalciferol 6,00,000 IU IM ampoule (Abbott)) is high-dose intramuscular vitamin D3 (cholecalciferol) used as a single annual depot in severe vitamin D deficiency, malabsorption, or when oral adherence is unreliable.
- 6,00,000 IU (600,000 IU) cholecalciferol depot per ampoule
- Hospital or clinic IM administration only
- Single annual dose in selected cases — not for general supplementation
- WHO-GMP certified manufacturer
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Arachitol 6L is a single 6,00,000 IU intramuscular depot — this is 10× the weekly Calcirol oral dose delivered in one shot. It must be administered by a qualified healthcare professional, never self-injected. Most adults with mild-to-moderate vitamin D deficiency should use oral Calcirol weekly instead; the IM depot is reserved for documented severe deficiency, malabsorption, or unreliable oral adherence.
What is Arachitol 6L Injection?
Arachitol 6L is a deep-IM cholecalciferol oily injection delivering 6,00,000 IU (600,000 IU) per ampoule. After IM injection, cholecalciferol is slowly released from muscle into circulation over weeks-to-months, hydroxylated in the liver to 25-OH-D, and then activated to calcitriol in the kidney. Serum 25-OH-D rises gradually and remains elevated for 6–12 months from a single dose.
Indications
- Severe vitamin D deficiency (25-OH-D < 10 ng/ml) with osteomalacia, rickets, or proximal myopathy
- Chronic malabsorption (coeliac disease, Crohn’s, post-bariatric, pancreatic insufficiency, cystic fibrosis)
- Unreliable oral adherence in elderly fall-risk patients
- Anticonvulsant-induced osteomalacia in patients on long-term enzyme-inducing drugs
- Adjunct to bisphosphonates in severe osteoporosis with deficiency
| Population | Dose | Frequency | Re-check |
|---|---|---|---|
| Adults, severe deficiency | 1 ampoule (6,00,000 IU) | Single dose; consider repeat at 6 months if level <30 ng/ml | 12 weeks then 6 months |
| Chronic malabsorption | 1 ampoule | Annual or 6-monthly under specialist guidance | 6 months |
| Anticonvulsant-induced osteomalacia | 1 ampoule | Annual | 6 months |
| Bariatric post-op (severe) | 1 ampoule | Specialist titration; oral often added | 6 months |
Side effects
- Local injection site — pain, lump, occasional sterile abscess (technique-dependent)
- Hypercalcaemia — uncommon at single 6,00,000 IU dose but possible especially with concurrent calcium supplementation, granulomatous disease, or repeat dosing without level checks
- Hypercalciuria — monitor in patients with kidney stone history
Drug interactions
As for oral cholecalciferol — thiazide diuretics potentiate hypercalcaemia, anticonvulsants increase requirement, glucocorticoids antagonise vitamin D action, digoxin toxicity is amplified by hypercalcaemia, and sarcoidosis or other granulomatous disease is a contraindication.
Contraindications
- Hypercalcaemia, hypervitaminosis D
- Active granulomatous disease (sarcoidosis, tuberculosis with active inflammation)
- Severe renal impairment (use activated forms instead)
- Hypersensitivity to peanut oil if formulation contains it (check ampoule excipients)
Storage
Store below 25°C, protect from light. Use ampoule once opened.
Frequently Asked Questions
When should I choose Arachitol over Calcirol?
Only when oral cholecalciferol has failed or is impractical. Indications: severe malabsorption (coeliac, Crohn’s, post-bariatric, pancreatic insufficiency), unreliable oral adherence in fall-risk elderly, severe deficiency where rapid replenishment matters, or enzyme-inducing anticonvulsants. Otherwise oral Calcirol is preferred.
How long does one injection last?
Serum 25-OH-D rises over 4–8 weeks and remains elevated for 6–12 months in most patients. A single ampoule annually is typical maintenance.
Can I inject myself?
No. This is a 6,00,000 IU oily IM depot — deep gluteal injection by a healthcare professional, with attention to technique to avoid local sterile abscess. Self-injection risks include sciatic nerve injury, sterile abscess, and dosing errors.
Is the injection painful?
Some local discomfort and occasional palpable lump at the injection site is normal. Severe pain or worsening swelling after a few days needs medical assessment.
How does it differ from oral Calcirol?
Same molecule (cholecalciferol). Calcirol is oral granules, 60,000 IU per sachet, weekly loading then monthly maintenance — suitable for the vast majority of patients. Arachitol 6L is IM, 6,00,000 IU per ampoule, single annual dose — reserved for malabsorption, adherence problems, or severe deficiency.
Can I take oral calcium with Arachitol?
Yes, if calcium intake is low or osteoporosis is being treated. Watch for hypercalcaemia symptoms (nausea, polyuria, confusion) especially in the first 4–8 weeks after the injection.
Is it safe in pregnancy?
Use only under obstetric guidance. Oral supplementation is preferred in pregnancy at lower doses (1,000–2,000 IU/day or weekly Calcirol). The 6,00,000 IU IM depot is rarely needed in pregnancy and should be avoided unless severe deficiency with malabsorption is present.
Can elderly patients use it?
Yes — in fact this is one of the strongest indications. Frail elderly patients with confirmed deficiency, fall risk, or unreliable adherence benefit from a once-yearly IM depot more than from a daily tablet they may forget.
How quickly will my level rise?
25-OH-D typically rises into the replete range (>30 ng/ml) by week 8 and peaks around week 12. Re-check at 12 weeks if rapid response is needed; otherwise check at 6 months and decide on the next dose.
Will I need it every year?
Most patients with chronic malabsorption or non-adherence to oral therapy need annual dosing. Some elderly fall-risk patients can be transitioned to daily oral 1,000–2,000 IU once stable. Decide based on 6-month 25-OH-D levels.
Other Vitamins & Minerals
- Calcirol — cholecalciferol 60,000 IU sachet
- Arachitol 6L Injection — cholecalciferol 6,00,000 IU IM depot
- Alphadol — alfacalcidol for CKD-related deficiency
- Cipcal — calcium carbonate + vitamin D
- Topcal M — calcium + magnesium + vitamin D
- Osteofos — alendronic acid for osteoporosis
Medical Disclaimer
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| Strength | 15mg/1ml |
|---|---|
| Quantity | 6 Ampoule/s, 12 Ampoule/s, 18 Ampoule/s, 36 Ampoule/s |
Arachitol 6L Injection
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Arachitol 6L Injection
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