Affexor XR

✅ Elevates mood
✅ Csökkenti a depresszió tüneteit
✅ Improves energy levels
✅ Enhances focus and concentration
✅ Helps manage anxiety

Affexor XR contains Venlafaxine.

SKU: N/A Kategória: Kategória áttekintése, Krónikus betegségek, Helyzeti szorongás kezelése Címke: Affexor XR, Venlafaxine

✓ Orvosi ellenőrzés Morgan Ellis — Gyógyszerkutató · 8 év tapasztalat · Utolsó felülvizsgálat: 2026 május

Több vásárlás, több megtakarítás Ár tablettánként

Válasszon erősséget a csomagárak megtekintéséhez.

Titkosított fizetés

Kriptovaluta fizetés 10% kedvezmény

Diszkrét világszerte szállítás

1 400+ vásárló · 50+ ország

Erősség

75 mg
150 mg

Mennyiség

30 tabletta
60 Tablet/s
90 tabletta
180 tabletta

Törlés

⚡ Quick Answer — What is Affexor XR?

Affexor XR tartalmaz venlafaxine ER (37.5 / 75 / 150 mg ER) from a WHO-GMP certified manufacturer (Pfizer (India)) — an SNRI with broad evidence in depression and anxiety-spectrum disorders. Standard start: 75 mg once daily with food; titrate to 150–225 mg/day for full SNRI activity (max 375 mg in MDD, 225 mg in GAD/social anxiety/panic). Onset: 2–4 weeks. Below 150 mg the drug behaves mostly as an SSRI; norepinephrine reuptake inhibition appears at higher doses. Important: dose-dependent blood-pressure rise (BP must be monitored at > 225 mg). Has a severe discontinuation syndrome — mandatory taper. More dangerous in overdose than SSRIs (cardiac toxicity, seizures).

Mit kapsz a MedsBase-nál: WHO-GMP minősítésű gyártó · Diszkrét csomagolás · Világszerte szállítás · 1.400+ hitelesített vásárlói vélemény

📦 Minden rendelést fedez a Újraküldési Garancia — ha a csomagod nem érkezik meg 20 munkanapon belül, újraküldjük.

Miért rendelj a MedsBase-ról

Generikus gyógyszereink WHO-GMP minősítésű gyártóktól származnak, és diszkrét, egyszerű csomagolásban szállítjuk őket világszerte — a csomagon nem szerepel a gyógyszer neve. A kártyás fizetések egy szabályozott feldolgozón keresztül történnek (a számlaleírások egy szabályozott kártyafizetési feldolgozót tartalmaznak — soha nem “MedsBase” vagy bármilyen gyógyszer neve). Kriptovalutát és SEPA banki átutalást is elfogadunk. Minden rendelést a Reshipment Assurance Policy biztosíték fedez.

Important — this is not a situational-anxiety medication. Affexor XR is a serotonin-norepinephrine reuptake inhibitor (SNRI), prescribed and titrated over weeks for major depressive disorder (MDD), generalised anxiety disorder (GAD), social anxiety disorder, and panic disorder. It is nem the right drug for acute, performance-related anxiety (flying, public speaking, exams) — for those use cases beta-blockers (propranolol), benzodiazepines, or hydroxyzine are clinically appropriate. If you do not have a diagnosed mood, anxiety, or psychiatric disorder, do not start this medication.

FDA black-box warning — suicidality. All antidepressants carry an FDA black-box warning for increased risk of suicidal thinking and behaviour in children, adolescents, and young adults under 25, particularly during the first weeks of treatment or after dose changes. Family members and prescribers should monitor closely for worsening mood, agitation, or suicidal ideation in this age group.

What Is Affexor XR?

Affexor XR is an oral extended-release tablet/capsule of venlafaxine (37.5 / 75 / 150 mg ER) manufactured by Pfizer (India) under WHO-GMP certification. Venlafaxine (US brand Effexor XR) is the prototype serotonin-norepinephrine reuptake inhibitor (SNRI). It blocks both the serotonin transporter (SERT) at lower doses and the norepinephrine transporter (NET) at higher doses, producing a dose-dependent shift from SSRI-like to SNRI-like pharmacology.

It is a first-line option in NICE and APA guidelines for major depression and is one of the most-evidenced antidepressants for generalised anxiety disorder.

Jóváhagyott indikációk

Major depressive disorder (MDD) — including treatment-resistant depression at higher doses
Generalised anxiety disorder (GAD)
Social anxiety disorder (chronic / generalised)
Panic disorder — with and without agoraphobia
Off-label: diabetic neuropathy, chronic fatigue, fibromyalgia, vasomotor symptoms of menopause

Adagolás

Agoprex is a 25 mg agomelatine tablet supplied by Sun Pharma. Agomelatine is mechanistically unique among antidepressants: it acts as an agonist at melatonin MT1 and MT2 receptors and an antagonist at 5-HT2C serotonin receptors. The dual mechanism resynchronises disrupted circadian rhythms (a feature of major depression) while indirectly increasing dopamine and noradrenaline release in the frontal cortex.	Kezelés indítása	Typical effective range	Maximális	Megjegyzések
MDD	75 mg/day with food	150–225 mg/day	375 mg/day	Increase by 75 mg every 2 weeks
GAD, social anxiety, panic	37.5–75 mg/day	75–225 mg/day	225 mg/day	Slower up-titration in panic to avoid early agitation
Elderly / hepatic / renal impairment	37.5 mg/day	Up to 75–150 mg with caution	—	Reduce by 25–50% in moderate hepatic impairment

Mechanism by Dose

Pharmacology shifts as dose climbs

Napi adag	Pharmacology	Clinical relevance
37.5–75 mg	Predominantly serotonergic (SSRI-like)	Useful as a starting / sub-therapeutic dose for tolerability
75–150 mg	Mostly serotonergic with emerging noradrenergic activity	Lower end of antidepressant efficacy range
150–225 mg	Combined SERT + NET inhibition (true SNRI)	Standard effective dose for most adults; full SNRI benefit
225–375 mg (MDD only)	Strong SERT + NET inhibition	Used in treatment-resistant depression; BP and cardiac monitoring required

Mellékhatások

Common, persistent, and rare side effects

Gyakoriság	Hatás	Notes / management
Gyakori	Nausea (dose-dependent)	Take with food; usually subsides over 1–2 weeks
Gyakori	Fejfájás, szédülés	Transient; adequate hydration
Gyakori	Insomnia or somnolence	Often dose in the morning if activating
Gyakori	Dry mouth, constipation, sweating	Sweating may persist; can be marked
Gyakori	Sexual dysfunction	Similar prevalence to SSRIs
Less common	Increased blood pressure (dose-dependent)	Check BP at baseline and periodically; significant rise above 225 mg/day in 5–10% — may need dose reduction or switch
Less common	Increased pulse, palpitations	Caution in patients with cardiac disease
Less common	Weight changes (modest)	Less weight gain than paroxetine or mirtazapine
Ritka	Hyponatraemia (SIADH)	Older adults at greatest risk
Ritka	Bleeding risk	Caution with NSAIDs, anticoagulants
Ritka	Serotonin syndrome	See interactions
Ritka	Mydriasis / acute angle-closure glaucoma	Caution in narrow-angle glaucoma

Discontinuation Syndrome

Venlafaxine has a short half-life (parent ~5 h; active metabolite desvenlafaxine ~11 h). Discontinuation symptoms are severe and rapid, second only to paroxetine: brain zaps, dizziness, nausea, sweating, irritability, insomnia, vivid dreams, flu-like aches. Often appear within 24–48 hours of a missed dose.

Mandatory slow taper: reduce by 75 mg every 2–4 weeks; below 75 mg use the smallest available capsule and consider every-other-day or hyperbolic tapering. Never stop abruptly. Patients on long-term venlafaxine often spend months on tapering — this is normal.

Gyógyszerkölcsönhatások

Absolute contraindications: MAOIs, linezolid, methylene blue. 14-day washout.

Serotonergic interactions: triptans, tramadol, pethidine, dextromethorphan, St John’s wort, lithium — serotonin syndrome risk.

CYP2D6 substrate: levels rise with strong CYP2D6 inhibitors (paroxetine, fluoxetine, bupropion, quinidine). Consider dose reduction.

Bleeding risk: NSAIDs, aspirin, warfarin, DOACs.

Cardiac and Overdose Considerations

Venlafaxine is more dangerous in overdose than SSRIs: cardiac conduction abnormalities, QT prolongation, seizures, and serotonin syndrome have been reported. Provide only short supplies to patients at acute suicide risk. Pre-existing significant cardiac disease, recent MI, or uncontrolled hypertension are relative contraindications.

Gyakran Ismételt Kérdések

How long does Affexor XR take to work?

Anxiety symptoms often improve in 2–3 weeks; mood response in MDD typically appears at 4–6 weeks. Patients on sub-therapeutic doses (< 150 mg) may need dose escalation before seeing full benefit.

Why does the dose matter so much for venlafaxine?

Below 150 mg/day, venlafaxine acts mostly like an SSRI — norepinephrine reuptake inhibition appears only at higher doses. Patients who don’t respond at 75 mg often respond once titrated to 150 mg or above.

Will Affexor XR raise my blood pressure?

Possibly — venlafaxine causes dose-dependent BP increases. Below 150 mg the effect is small; above 225 mg, 5–10% of patients see clinically significant increases. BP should be monitored at baseline and after dose escalations.

Can I stop Affexor XR abruptly?

No — venlafaxine has one of the worst discontinuation syndromes in the antidepressant class (brain zaps, dizziness, nausea, sweating). Mandatory taper, often over months for long-term users.

Is Affexor XR safe in pregnancy?

Limited data — not the first-choice antidepressant in pregnancy. Sertraline is preferred. Late-third-trimester exposure carries a small risk of neonatal adaptation syndrome and persistent pulmonary hypertension of the newborn.

Does Affexor XR cause weight gain?

Less than paroxetine or mirtazapine. Some patients see modest weight changes; others lose weight from initial GI side effects. Less metabolic burden than antipsychotics.

Can I drink alcohol on Affexor XR?

Light, occasional alcohol is generally tolerated. Heavy alcohol use worsens depression / anxiety, increases sedation, and is implicated in disinhibited behaviour.

Mi történik, ha kihagyok egy adagot?

Take it as soon as you remember unless close to the next dose. Withdrawal symptoms can begin within 24–48 hours of a missed dose — do not skip multiple doses.

How is Affexor XR different from duloxetine or desvenlafaxine?

All are SNRIs. Duloxetine has a different binding profile (more SNRI even at lower doses, hepatic concerns), is also approved for diabetic neuropathy and fibromyalgia. Desvenlafaxine is the active metabolite of venlafaxine — bypasses CYP2D6 metabolism, more predictable plasma levels.

How should Affexor XR be stored?

Store at 15–30 °C in the original blister packaging, away from moisture and sunlight. Keep out of reach of children — venlafaxine overdose is medically significant.

Orvosi felelősségi nyilatkozat: Information on this page is intended for adults using prescribed psychiatric medication and is not a substitute for individualised medical care. Antidepressants, antipsychotics, and related medications can interact with other drugs, alcohol, and pre-existing conditions. Discuss any new medication, dose change, or planned discontinuation with a qualified prescriber. If you experience suicidal thoughts, mania, severe akathisia, signs of serotonin syndrome (high fever, confusion, muscle rigidity, rapid heart rate), or neuroleptic malignant syndrome, seek emergency care immediately.