Olanzoop
Olanzoop (Olanzapine 5/10 mg) — thienobenzodiazepine atypical for schizophrenia and bipolar mania. mandatory weight, glucose and lipid monitoring.
✓ Orvosi ellenőrzés Morgan Ellis — Gyógyszerkutató · 8 év tapasztalat · Utolsó felülvizsgálat: 2026 május
⚡ Gyors válasz
Olanzoop (Olanzapine 5 / 10 mg) is an atypical antipsychotic for schizophrenia, bipolar mania and maintenance, treatment-resistant depression (with fluoxetine), and acute agitation. The most robust antipsychotic effect of the atypicals — but the heaviest metabolic burden.
📦 Minden rendelést fedez a Újraküldési Garancia — ha a csomagod nem érkezik meg 20 munkanapon belül, újraküldjük.
Miért rendelj a MedsBase-ról
Olanzoop at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our Újraküldési Garancia — 20 üzleti napos érkezési ablak vagy ingyenes újraszállítás — és jogosult a mi hűségprogramunkra. .
What Olanzoop is and how it works
Olanzoop is an olanzapine tablet supplied by Cipla. Available strengths: 5 / 10 mg. Olanzapine is a thienobenzodiazepine atypical antipsychotic with strong D2 antagonism, strong 5-HT2A antagonism, and substantial H1 (sedation, weight gain), M1 (anticholinergic), and α1 (orthostasis) blockade. The H1+M1 receptor profile is responsible both for its calming/sedative effect (useful in acute agitation) and for its metabolic burden.
What Agoprex is and how it works
| Agoprex is a 25 mg agomelatine tablet supplied by Sun Pharma. Agomelatine is mechanistically unique among antidepressants: it acts as an agonist at melatonin MT1 and MT2 receptors and an antagonist at 5-HT2C serotonin receptors. The dual mechanism resynchronises disrupted circadian rhythms (a feature of major depression) while indirectly increasing dopamine and noradrenaline release in the frontal cortex. | Agomelatine has no SERT activity, no anticholinergic effects, and no histaminergic effects — explaining its very different side-effect profile from SSRIs and TCAs. | Indications and dosing | Indication |
|---|---|---|---|
| Skizofrénia (felnőtt) | 5–10 mg OD | 10–20 mg naponta | 20 mg |
| Skizofrénia (serdülő ≥ 13 éves) | 2.5–5 mg OD | 10 mg/nap | 20 mg |
| Bipoláris mániás epizód (felnőtt) | 10–15 mg/nap | 10–20 mg naponta | 20 mg |
| Acute agitation (IM) | 10 mg IM | — | 3 adag/24 óra |
| Treatment-resistant depression (with fluoxetine) | 5 mg + 20 mg fluoxetine | 5–18 mg | 18 mg |
| Idősek | 2.5–5 mg OD | 5–10 mg OD | tolerancia alapján |
Fontos biztonsági megfontolások
Az összes atípusos antipszichotikum hordoz egy FDA fekete doboz figyelmeztetést a megnövekedett halálozási kockázat miatt (főleg cardiovascularis és fertőzéses okokból), amikor idős, demenciában szenvedő betegek viselkedészavarainak kezelésére használják. Az atípusos antipszichotikumok nincsenek jóváhagyva demenciával összefüggő pszichózis vagy agitáció kezelésére. Használatuk ebben a populációban off-label, utolsó lehetőség, időkorlátozott, és kifejezett kockázat-haszon beszélgetést igényel.
Olanzapine produces the most weight gain (typically 4–10 kg in the first 6 months, sometimes far more), the most insulin resistance, and the most lipid disturbance of any commonly-used antipsychotic. Patients can develop type 2 diabetes within months of initiation. Mandatory monitoring: weight at every visit; fasting glucose / HbA1c and fasting lipids at baseline, 12 weeks, then 6-monthly. Counsel about diet and exercise from initiation.
Strong sedation in the first 1–2 weeks. Anticholinergic effects (dry mouth, constipation, urinary hesitancy) are universal. Both lessen but do not disappear.
Combining IM olanzapine with parenteral benzodiazepines has produced cases of severe hypotension, respiratory depression, and death. If both are clinically necessary in acute agitation, separate by ≥ 1 hour and monitor closely.
Gyakori mellékhatások
- Testsúlygyarapodás és anyagcserezavar — the dominant long-term concern.
- Sedation — universal at initiation.
- Ortosztatikus hypotónia — common at initiation; titrate slowly in older adults.
- Anticholinerg — dry mouth, constipation, urinary hesitancy.
- Akathisia, EPS — less common than risperidone, more common than aripiprazole.
- Prolaktin — modest rise; less than risperidone.
- Hepatic — transient AST/ALT rises common.
Gyógyszerkölcsönhatások
- CYP1A2 gátlók (fluvoxamine, ciprofloxacin) — raise olanzapine levels markedly.
- Dohányzás — induces CYP1A2; smokers have lower levels and need higher doses; smoking cessation can produce toxicity.
- Karbamazepin — strong CYP1A2 induction; raises olanzapine clearance.
- KNS depresszánsok — additív nyugtatás.
- Anticholinerg szerek — additív terhelés.
Terhesség, szoptatás, gyermekkori kor
Pregnancy: limited data; weigh against untreated illness; late-pregnancy exposure can produce neonatal EPS or withdrawal. Breastfeeding: passes into milk; usually requires alternative or close monitoring. Paediatric: licensed from 13 (schizophrenia, bipolar).
Tárolás
15–30 °C között tároljuk eredeti csomagolásban.
Gyakran Ismételt Kérdések
Why does Olanzoop cause so much weight gain?
Olanzapine’s combined H1 antihistamine, 5-HT2C antagonism, and other receptor effects produce strong appetite stimulation, slowed satiety, and shifted carbohydrate preference. Weight gain is dose-related but real even at low doses. Counselling about diet and exercise from week 1, plus regular weight monitoring, is mandatory.
How is Olanzoop different from risperidone or aripiprazole?
Olanzapine has the strongest acute antipsychotic effect and the fastest calming action — useful in acute agitation. The trade-off is the heaviest metabolic burden. Risperidone is more efficacious for some positive symptoms but raises prolactin substantially. Aripiprazole is metabolically cleanest but produces more akathisia.
Should I monitor my blood sugar on Olanzoop?
Yes — fasting glucose or HbA1c at baseline, 12 weeks, and then 6-monthly. Olanzapine can produce diabetes within months of initiation, sometimes presenting with diabetic ketoacidosis. Don’t skip the monitoring.
Can Olanzoop be used long-term?
Yes — particularly for schizophrenia maintenance where olanzapine often outperforms other atypicals on relapse rate. The metabolic burden is the main reason long-term use requires careful weight, glucose, and lipid monitoring, plus active management of cardiometabolic risk.
How long until Olanzoop works?
Calming effect within 1–2 hours of the first oral dose. Antipsychotic effect builds over 1–2 weeks; full antipsychotic and mood-stabilising effect at 4–6 weeks.
What about driving on Olanzoop?
Avoid driving in the first 1–2 weeks of titration. Most patients on stable doses drive normally, but the sedation can be persistent at higher doses.
Is the orodispersible form different?
Yes — orodispersible (ODT) versions of olanzapine exist (Zyprexa Zydis, Olimelt) and dissolve on the tongue without water. Bioequivalent to standard tablets but useful in adherence-uncertain or dysphagia patients.
Can Olanzoop be combined with fluoxetine?
Yes — the olanzapine-fluoxetine combination (OFC, Symbyax) is FDA-approved for treatment-resistant depression and bipolar depression. The fluoxetine partly addresses olanzapine’s lack of antidepressant effect; olanzapine adds a strong mood-stabilising component.
Why does smoking matter?
Smoking strongly induces CYP1A2, which is olanzapine’s main metabolic enzyme. Smokers metabolise olanzapine faster and need higher doses; abrupt cessation of smoking (e.g. hospital admission) can produce olanzapine toxicity if the dose isn’t adjusted. Tell the prescriber if smoking status changes.
Can Olanzoop be stopped abruptly?
Generally not — taper over 2–4 weeks. Abrupt cessation can produce cholinergic rebound (nausea, sweating, insomnia) and an antipsychotic relapse. Never stop without prescriber agreement.
Egyéb Pszichés Egészségügyi Gyógyszerek
- Aripicon (Aripiprazole — D2 részleges agonista)
- Olanzap (Olanzapin — erős antipszichotikum)
- Risdone (Risperidon)
- Seroquit (Kvetiapin — bipoláris depresszió)
- Atlura (Lurasidon — metabolikusan kedvező)
További lehetőségek a Pszichés Egészségügyi és Pszichiátriai Gyógyszerek között
Rangsorolva a MedsBase legutóbbi rendelési adatai alapján — hogy ebben a kategóriában más vásárlók mit választanak.
| Erősség | 10 mg |
|---|---|
| Mennyiség | 30 tabletta, 60 tabletta, 90 tabletta, 180 tabletta |
Olanzoop
Kérdések és válaszok
Olanzoop
Kapcsolódó termékek
Vélemények
Még nincsenek vélemények