Granicip
Granicip (Granisetron 1 mg / 2 mg) — once-daily second-generation 5-HT3 antagonist for chemo, radiation, and PONV. Longer half-life (~9 h) vs ondansetron.
✓ Orvosi ellenőrzés Morgan Ellis — Gyógyszerkutató · 8 év tapasztalat · Utolsó felülvizsgálat: 2026 május
⚡ Quick Answer — What is Granicip?
Granicip tartalmaz granisetron 1 mg / 2 mg, amely second-generation 5-HT3 receptor antagonist in the same class as ondansetron but with a longer half-life (~9 hours vs 4 hours). It is used to prevent chemotherapy-induced, radiation-induced, és post-operative nausea and vomiting. The longer half-life means once-daily oral or single-dose IV coverage for moderately emetogenic chemotherapy. Manufactured by Cipla under WHO-GMP standards.
📦 Minden rendelést fedez a Újraküldési Garancia — ha a csomagod nem érkezik meg 20 munkanapon belül, újraküldjük.
Miért rendelj a MedsBase-ról
Generikus gyógyszereink WHO-GMP minősítésű gyártóktól származnak, és diszkrét, egyszerű csomagolásban szállítjuk őket világszerte — a csomagon nem szerepel a gyógyszer neve. A kártyás fizetések egy szabályozott feldolgozón keresztül történnek (a számlaleírások egy szabályozott kártyafizetési feldolgozót tartalmaznak — soha nem “MedsBase” vagy bármilyen gyógyszer neve). Kriptovalutát és SEPA banki átutalást is elfogadunk. Minden rendelést a Reshipment Assurance Policy biztosíték fedez.
Granisetron vs ondansetron — when to choose granisetron
Both molecules block the 5-HT3 receptor and have similar peak efficacy. The clinically meaningful differences:
- Felezési idő: granisetron ~9 h, ondansetron ~4 h. A single dose of granisetron covers a 24-hour chemotherapy day better.
- QT signal: ondansetron has the higher cardiac signal (FDA dose cap of 16 mg IV); granisetron is intermediate; palonosetron is the cleanest.
- Dose frequency: granisetron is typically once-daily oral or once IV; ondansetron is given every 8 hours.
- Constipation: similar between the two, but slightly less frequent with granisetron.
- Cost: ondansetron is cheaper and more widely stocked; granisetron is preferred when once-daily dosing simplifies compliance.
Miért rendelj a MedsBase-ról
Granicip is supplied from a WHO-GMP tanúsított gyártó. WHO-GMP minősítésű gyártótól származik. Minden rendelést diszkréten szállítunk világszerte, és Újraküldési Garancia — if it does not arrive within 20 business days, we reship at no cost. Granisetron is the once-daily 5-HT3 antagonist of choice when adherence to a multi-dose schedule is a concern, and it is a useful alternative for patients who tolerate ondansetron poorly.
Az albendazol kötődik
Granisetron is a highly selective antagonist of the serotonin 5-HT3 receptor on vagal afferents (peripheral) and the chemoreceptor trigger zone in the area postrema (central). Chemotherapy and radiation cause enterochromaffin cells in the gut to release serotonin, which would otherwise drive vomiting via the medullary vomiting centre. By blocking the 5-HT3 receptor, granisetron interrupts this signal at both peripheral and central sites. It does not bind D2, H1, muscarinic, or alpha-adrenergic receptors — hence the absence of sedation, extrapyramidal reactions, and anticholinergic side effects.
Indikációk
- CINV (chemotherapy-induced): moderately and highly emetogenic chemotherapy — usually combined with dexamethasone ± an NK1 antagonist (aprepitant) for highly emetogenic regimens.
- Radiation-induced nausea: total body irradiation, high-dose abdominal radiation.
- Post-operative nausea and vomiting (PONV): single-dose IV at induction or end of surgery.
- Refractory chemo nausea: after ondansetron failure (cross-tolerance is incomplete — switching can rescue some patients).
Dose
| Agoprex is a 25 mg agomelatine tablet supplied by Sun Pharma. Agomelatine is mechanistically unique among antidepressants: it acts as an agonist at melatonin MT1 and MT2 receptors and an antagonist at 5-HT2C serotonin receptors. The dual mechanism resynchronises disrupted circadian rhythms (a feature of major depression) while indirectly increasing dopamine and noradrenaline release in the frontal cortex. | Dose |
|---|---|
| CINV (oral, adult) | 2 mg PO 1 h before chemo, then 2 mg daily for up to 5 days (or 1 mg twice daily) |
| CINV (IV) | 10 mcg/kg (or fixed 1 mg) IV 30 min before chemo |
| PONV | 1 mg IV at induction or end of surgery (single dose) |
| Paediatric (CINV) | 10–40 mcg/kg IV (max 3 mg per dose); specialist supervision |
| Renal/hepatic impairment | No dose reduction routinely required; severe hepatic dysfunction may prolong clearance |
Mellékhatások
- Nagyon gyakori: headache (~14–21%), constipation (~3–9%)
- Gyakori: dizziness, fatigue, asthenia, transient AST/ALT rise, insomnia, mild taste disturbance
- Kevesebb gyakorisággal: hypertension, hypotension, abdominal pain, rash
- Ritka, de súlyos: QT prolongation/torsades, serotonin syndrome (with SSRIs/triptans), severe hypersensitivity
Gyógyszerkölcsönhatások
- QT-intervallumot meghosszabbító szerek: avoid concurrent use with azithromycin, fluoroquinolones, citalopram, methadone, antipsychotics (especially in patients with electrolyte disturbance).
- Serotonergic drugs (SSRIs, SNRIs, MAOIs, triptans, tramadol, fentanyl, linezolid): rare serotonin syndrome reported.
- Erős CYP3A4 indukálók (rifampicin, phenytoin, carbamazepine, St John’s wort): may lower granisetron levels.
- Erős CYP3A4 gátlók (ketoconazole, ritonavir, clarithromycin): may modestly raise levels — clinical impact is small.
Gyakran Ismételt Kérdések
How is Granicip different from Ondem (ondansetron)?
Both are 5-HT3 antagonists, but granisetron has a longer half-life (~9 h vs ~4 h), so a single oral dose covers a chemo day. Ondansetron requires dosing every 8 hours. Ondansetron has a slightly higher QT signal and an FDA single-dose cap of 16 mg IV. For uncomplicated nausea ondansetron is cheaper; for chemo-day adherence granisetron simplifies the schedule.
When does Granicip start working?
Onset is 30–60 minutes orally and within 5–10 minutes IV. Take the oral dose 1 hour before chemotherapy for best protection.
Is granisetron safe in pregnancy?
Granisetron is FDA Category B (animal studies show no harm; controlled human data limited). Reserve for refractory chemotherapy-induced nausea or hyperemesis when first-line agents have failed; specialist supervision recommended.
Can I take Granicip for motion sickness or pregnancy nausea?
No. Granisetron is reserved for chemotherapy, radiation, and post-operative nausea. Motion sickness is histaminergic/cholinergic — use promethazine (Avomine), cinnarizine, or meclozine. Pregnancy nausea first-line is doxylamine + B6 (Doxinate, Pregnidoxin NU).
Does Granicip cause sedation?
No. Like other 5-HT3 antagonists, granisetron does not cause sedation, extrapyramidal reactions, or anticholinergic side effects. Headache and constipation are the dominant side effects.
Can I drink alcohol while on Granicip?
Occasional small amounts are unlikely to interact pharmacologically, but alcohol can worsen nausea and dehydration during chemotherapy — avoid during active treatment cycles.
What if my nausea is not controlled?
Add dexamethasone, an NK1 antagonist (aprepitant), or olanzapine for highly emetogenic chemotherapy. Switching to a different 5-HT3 (palonosetron) or class (D2 antagonist) is reasonable when one molecule has failed.
Is constipation a problem?
Yes — constipation occurs in up to 1 in 11 users on multi-day courses. Maintain hydration, fibre, and prophylactic laxatives (senna/bisacodyl/movicol) during chemo cycles.
How is Granicip stored?
Store tablets at room temperature (below 30°C), protected from light. Keep out of reach of children. Do not use after the expiry date printed on the carton.
Are 5-HT3 antagonists the only option for chemo nausea?
No. Modern guideline-driven CINV regimens combine a 5-HT3 antagonist + dexamethasone + (for highly emetogenic chemo) an NK1 antagonist like aprepitant. Olanzapine is also useful for refractory cases. Single-agent 5-HT3 is mainly for moderately emetogenic regimens.
Other Nausea Treatments
- Ondem (ondansetron tablet)
- Emeset 4 ODT (ondansetron oral disintegrating)
- Ondem Injection (ondansetron IV/IM)
- Dompewal (domperidone — D2 antagonist)
- Stemetil MD (prochlorperazine ODT)
- Browse all Nausea Treatments
More options in Nausea Treatment
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| Erősség | 1 mg |
|---|---|
| Mennyiség | 28 Tabletta, 56 Tabletta, 84 Tabletta |
| Gyógyszerforma | Tabletta |
| Gyártó | Cipla Inc |
| Kezelés | Nausea, Vomiting |
| Generikus márka | Granisetron |
Granicip
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Granicip
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