Qutan SR 400
Qutan SR 400 (Quetiapine 400 mg SR) — extended-release atypical for schizophrenia, bipolar mania, bipolar depression, MDD adjunct. flatter sedation peak than IR — once-daily dosing.
✓ Orvosi ellenőrzés Morgan Ellis — Gyógyszerkutató · 8 év tapasztalat · Utolsó felülvizsgálat: 2026 május
⚡ Gyors válasz
Qutan SR 400 (Quetiapine 400 mg SR, extended/sustained-release) is an atypical antipsychotic for schizophrenia, bipolar mania, bipolar depression, MDD adjunct, and GAD adjunct. Strongly sedating and metabolically heavy — but uniquely effective for bipolar depression. Often misused as a “sleeping pill” — discouraged because of metabolic burden.
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What Qutan SR 400 is and how it works
Qutan SR 400 is a quetiapine extended/sustained-release tablet supplied by Cipla. Available strengths: 400 mg SR. Quetiapine has loose D2 binding (rapid dissociation explains low EPS), strong 5-HT2A antagonism, very strong H1 antihistamine action (sedation, weight gain), α1-adrenergic antagonism (orthostasis), and α2 antagonism. Its active metabolite, norquetiapine, has noradrenaline transporter inhibition — the basis for the antidepressant effect in bipolar depression.
The SR/XR formulation is dosed once daily, generally at bedtime. The IR formulation is split BID. SR has slightly lower peak sedation and may be better tolerated for daytime function.
What Agoprex is and how it works
| Agoprex is a 25 mg agomelatine tablet supplied by Sun Pharma. Agomelatine is mechanistically unique among antidepressants: it acts as an agonist at melatonin MT1 and MT2 receptors and an antagonist at 5-HT2C serotonin receptors. The dual mechanism resynchronises disrupted circadian rhythms (a feature of major depression) while indirectly increasing dopamine and noradrenaline release in the frontal cortex. | Agomelatine has no SERT activity, no anticholinergic effects, and no histaminergic effects — explaining its very different side-effect profile from SSRIs and TCAs. | Indications and dosing | Indication |
|---|---|---|---|
| Schizophrenia (SR) | Max | 400–800 mg/day | 800 mg |
| Bipolar mania | 50 mg BID (IR) or 300 mg HS (SR) | 400–800 mg/day | 800 mg |
| Bipolar depression | Max | 300 mg HS | 600 mg |
| MDD adjunct (SR) | Max | 150–300 mg HS | 300 mg |
| GAD adjunct (off-label) | Max | 50–150 mg HS | — |
| Older adults | Target | 50–200 mg/day | by tolerability |
Fontos biztonsági megfontolások
All atypical antipsychotics carry an FDA black-box warning for increased mortality (mostly cardiovascular and infectious) when used to treat behavioural disturbance in older adults with dementia. Atypicals are not approved for dementia-related psychosis or agitation. Use in this population is off-label, last-resort, time-limited, and requires explicit risk-benefit conversation.
Weight gain, insulin resistance, dyslipidaemia — second only to olanzapine and clozapine among atypicals. Mandatory monitoring at baseline, 12 weeks, then 6-monthly: weight, fasting glucose / HbA1c, fasting lipids, BP. Counsel about diet/exercise from initiation.
α1 antagonism produces orthostatic hypotension, particularly in older adults and at initiation. Titrate slowly. Check sitting and standing BP at follow-up.
Low-dose quetiapine (25–50 mg HS) is widely used off-label as a hypnotic. The metabolic burden is the same regardless of indication — patients on quetiapine for sleep gain weight and develop insulin resistance just as much as patients on quetiapine for psychosis. Dedicated hypnotics (Z-drugs, low-dose doxepin, melatonin agonists, behavioural sleep therapy) are usually safer choices for primary insomnia.
When used as an antidepressant adjunct, the under-25 suicidality warning applies.
Gyakori mellékhatások
- Sedation — universal; harness as bedtime benefit.
- Weight gain and metabolic syndrome — heavy.
- Ortosztatikus hypotónia és szédülés — common at initiation.
- Dry mouth, constipation — moderate anticholinergic effect.
- Tachycardia — often noticed.
- EPS / akathisia — less common than risperidone or olanzapine.
- Prolactin — usually normal or low.
- QT — modest dose-dependent prolongation.
Gyógyszerkölcsönhatások
- Erős CYP3A4 gátlók (azoles, clarithromycin, ritonavir, grapefruit juice) — raise quetiapine levels several-fold; reduce dose or avoid.
- Erős CYP3A4 indukálók (rifampicin, carbamazepine, phenytoin, St John’s wort) — reduce levels; may need higher doses or switch.
- Egyéb QT-idejét meghosszabbító gyógyszerek — additive risk.
- CNS depressants — strong additive sedation.
- Antihipertenzív szerek — additive orthostasis.
Terhesség, szoptatás, gyermekkori kor
Pregnancy: limited data; late-pregnancy exposure can produce neonatal EPS. Breastfeeding: passes into milk in small amounts; usually compatible with monitoring. Paediatric: licensed from 13 (schizophrenia), 10 (bipolar mania).
Tárolás
15–30 °C között tároljuk eredeti csomagolásban.
Gyakran Ismételt Kérdések
Why is Qutan SR 400 so sedating?
Strong H1 antihistamine action plus α1-adrenergic blockade — this is the dominant pharmacology at low doses. The antipsychotic dopamine-D2 effect dominates only at higher doses. The clinical translation: 25–100 mg is mostly a sleeping pill; 200–400 mg starts to have antipsychotic effect; 600–800 mg is the antipsychotic dose range.
Is using Qutan SR 400 for sleep a good idea?
Probably not. The metabolic burden of quetiapine is identical at 25 mg and at 800 mg — patients on low-dose quetiapine for insomnia gain weight, develop insulin resistance, and accumulate cardiometabolic risk just as much as patients on full antipsychotic doses. Z-drugs, low-dose doxepin, melatonin agonists, and CBT-I are usually safer for primary insomnia.
Why is Qutan SR 400 effective in bipolar depression?
The norquetiapine metabolite inhibits the noradrenaline transporter — adding an antidepressant component to the sedating-stabilising profile of the parent drug. Quetiapine and lurasidone are the two main atypicals with FDA approval for bipolar depression; quetiapine is more sedating, lurasidone is metabolically cleaner.
Will Qutan SR 400 make me gain weight?
Yes — typically 3–7 kg over 6 months, sometimes more. Dose-related but real at all doses. Plot weight at every visit and counsel about diet/exercise from week 1.
How long until Qutan SR 400 works?
Sleep effect: same night. Mood/anxiety effect: 1–2 weeks. Antipsychotic effect: 2–6 weeks at adequate dose. Bipolar depression effect: 2–6 weeks.
What is the difference between IR and SR quetiapine?
Both have the same molecule and the same active metabolite. SR/XR delivers it more slowly, producing a flatter sedation peak — better for daytime function and easier once-daily dosing. IR has stronger immediate sedation, useful when bedtime sedation is desired.
Can Qutan SR 400 be stopped abruptly?
Taper over 2–4 weeks. Abrupt cessation can produce cholinergic rebound (nausea, sweating, insomnia) and antipsychotic relapse. Never stop without prescriber agreement.
What about driving on Qutan SR 400?
Avoid driving for at least the first 1–2 weeks of any new dose. Many patients on stable bedtime doses drive normally during the day; some patients on higher daytime doses or split BID dosing remain too sedated to drive safely.
Can Qutan SR 400 be combined with an SSRI?
Yes — quetiapine SR is FDA-approved as an adjunct to SSRI/SNRI in MDD at low doses (50–300 mg HS). Sometimes used in treatment-resistant anxiety as well.
Why avoid grapefruit juice?
Grapefruit juice strongly inhibits intestinal CYP3A4. Quetiapine is a CYP3A4 substrate; grapefruit raises levels markedly, increasing sedation, orthostasis, and metabolic burden. Avoid grapefruit and grapefruit juice during Qutan SR 400 therapy.
Egyéb Pszichés Egészségügyi Gyógyszerek
- Aripicon (Aripiprazole — D2 partial agonist)
- Olanzap (Olanzapine — robust antipsychotic)
- Risdone (Risperidone)
- Seroquit (Quetiapine — bipolar depression)
- Atlura (Lurasidone — metabolically clean)
További lehetőségek a Pszichés Egészségügyi és Pszichiátriai Gyógyszerek között
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| Erősség | 400 mg |
|---|---|
| Mennyiség | 30 tabletta, 60 tabletta, 90 tabletta, 180 tabletta |
Qutan SR 400
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Qutan SR 400
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