⚡ Quick Answer — What is Rcifax?
Rcifax is rifaximin 400 mg or 550 mg — a non-absorbable rifamycin antibiotic that acts almost entirely within the gut lumen. Three validated indications: traveller’s diarrhoea (non-invasive E. coli), prevention of overt hepatic encephalopathy in cirrhosis, and IBS-D (diarrhoea-predominant irritable bowel). Less than 0.4 percent of an oral dose is absorbed systemically, so off-target side effects, drug interactions, and resistance pressure on commensal bacteria are minimal. WHO-GMP certified manufacturer.
📦 Minden rendelést fedez a Újraküldési Garancia — ha a csomagod nem érkezik meg 20 munkanapon belül, újraküldjük.
Miért rendelj a MedsBase-ról
Generikus gyógyszereink WHO-GMP minősítésű gyártóktól származnak, és diszkrét, egyszerű csomagolásban szállítjuk őket világszerte — a csomagon nem szerepel a gyógyszer neve. A kártyás fizetések egy szabályozott feldolgozón keresztül történnek (a számlaleírások egy szabályozott kártyafizetési feldolgozót tartalmaznak — soha nem “MedsBase” vagy bármilyen gyógyszer neve). Kriptovalutát és SEPA banki átutalást is elfogadunk. Minden rendelést a Reshipment Assurance Policy biztosíték fedez.
Miért rendelj a MedsBase-ról
Rcifax is supplied from a WHO-GMP tanúsított gyártó. WHO-GMP minősítésű gyártótól származik. Minden rendelést diszkréten szállítunk világszerte, és Újraküldési Garancia — if it does not arrive within 20 business days, we reship at no cost. Rifaximin is endorsed by AASLD 2021 for hepatic encephalopathy prevention and by ACG 2021 for traveller’s diarrhoea and IBS-D — one of the few antibiotics with strong evidence in functional GI disorders.
— ha 20 munkanapon belül nem érkezik meg, ingyenesen újraküldjük. Ez az egyetlen hányásgátló kombináció, amely FDA A kategóriájú státusszal rendelkezik a terhesség alatt, és az ACOG, a NICE és a SOGC elsővonalbeli ajánlása a terhességi hányinger és hányás kezelésére.
Rifaximin binds the β-subunit of bacterial DNA-dependent RNA polymerase (rpoB), inhibiting bacterial RNA synthesis. Spectrum covers Gram-positive and Gram-negative aerobes and anaerobes including E. coli, Shigella, Salmonella, Campylobacter, and many enteric anaerobes. Because absorption is < 0.4 percent of the oral dose, the drug acts effectively only on intra-luminal organisms.
Indications & doses
| Agoprex is a 25 mg agomelatine tablet supplied by Sun Pharma. Agomelatine is mechanistically unique among antidepressants: it acts as an agonist at melatonin MT1 and MT2 receptors and an antagonist at 5-HT2C serotonin receptors. The dual mechanism resynchronises disrupted circadian rhythms (a feature of major depression) while indirectly increasing dopamine and noradrenaline release in the frontal cortex. | Dose | Időtartam |
|---|---|---|
| Traveller’s diarrhoea (non-invasive) | 200–400 mg three times daily | 3 nap |
| Hepatic encephalopathy — prevention | 550 mg twice daily | Long-term, with lactulose |
| IBS-D | 550 mg three times daily | 14 days; can be re-dosed up to 2 more times if symptoms recur |
| Small-intestinal bacterial overgrowth (SIBO) | 550 mg three times daily | 14 days (off-label) |
| Diverticulitis (mild) | 400 mg kétszer naponta | 7 days (off-label, with diet) |
When it is NOT the right drug
- Invasive enteric infection (fever, bloody stool, severe systemic illness) — needs ciprofloxacin or azithromycin systemically.
- Pseudomembranous colitis (C. difficile) — oral vancomycin or fidaxomicin is first-line; rifaximin has limited evidence as a relapse-prevention adjunct.
- Suspected typhoid — needs systemic antibiotic.
- Suspected appendicitis / cholangitis / pyelonephritis — needs systemic.
Mellékhatások
- Gastrointestinal: nausea, abdominal pain, flatulence (mostly mild)
- Fejfájás, szédülés
- Peripheral oedema (with HE-prevention long courses)
- C. difficile-associated diarrhoea (rare; the gut-selective profile reduces but does not eliminate this risk)
- Hypersensitivity reactions (rare): rash, urticaria, anaphylaxis
- Cross-reactivity with rifampicin/rifabutin in patients with rifamycin allergy
Gyógyszerkölcsönhatások
Rifaximin’s very low systemic absorption means clinically significant interactions are unusual. However:
- P-gp inhibitors (cyclosporin) raise the small absorbed fraction.
- Warfarin: isolated reports of INR change — check INR if used concurrently.
- Kombinált fogamzásgátló tabletta: oral contraceptive efficacy is theoretically reduced if rifaximin causes severe diarrhoea (transit time effect).
Gyakran Ismételt Kérdések
How quickly does it work in traveller’s diarrhoea?
Symptom improvement is usually within 24–48 hours. The 3-day course is sufficient for non-invasive E. coli, the most common cause. If symptoms are severe (fever, bloody stool) or do not improve in 48 hours, change to systemic antibiotic.
Does it cure IBS?
No. Rifaximin reduces IBS-D symptoms in about 40 percent of patients; benefit lasts 10–12 weeks. It can be repeated if symptoms recur. It is not a cure but a useful symptomatic intervention.
Why do I need lactulose with it for hepatic encephalopathy?
Lactulose acidifies the colon and ion-traps ammonia. Rifaximin reduces ammonia-producing bacteria. The two work synergistically; combination therapy reduces HE recurrence by ~60 percent versus lactulose alone.
Ihatok alkoholt közben?
There is no disulfiram-like interaction. However, traveller’s diarrhoea recovery and HE prevention both benefit from minimal alcohol intake.
Biztonságos terhesség alatt?
Category C. Used in pregnancy when the indication justifies it (HE in pregnant cirrhotic) under specialist advice. Discuss with obstetric prescriber.
How is it different from rifampicin?
Same drug-class binding target but rifampicin is highly absorbed (oral bioavailability ~90 percent) and used systemically for tuberculosis, leprosy, and meningococcal prophylaxis — with significant CYP3A4/2C19 induction and CYP-driven interactions. Rifaximin is gut-restricted with negligible systemic effect.
Will it disrupt my normal gut bacteria?
Yes, but transiently. The gut microbiome typically recovers within 2–4 weeks. Probiotics during and after the course may shorten recovery (modest evidence).
Is resistance a concern?
Rifaximin resistance can develop in enteric bacteria with repeated courses but the impact on systemic rifamycin use (rifampicin for TB, rifabutin for HIV) is limited because rifaximin is not used systemically. Still, avoid casual repeat courses.
Tárolás
Below 30°C, dry place. Keep blister sealed until use.
Mi a teendő, ha kihagyok egy adagot?
Take it as soon as you remember unless close to the next dose. Do not double up. Try to keep the schedule consistent.
Egyéb Gasztroenterológiai Gyógyszerek
- Rifagut — Rifaximin (alternate brand)
- Ciplox — Ciprofloxacin (systemic option for invasive enteric infection)
- Synclar — Klaritromicin (H. pylori)
- Cendox — Doxycycline
- Colospa — Mebeverin (IBS antispazmodikum)
- Összes Gasztroenterológiai Gyógyszer Tallózása





























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