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Wormentel

Wormentel (fenbendazole 222 / 444 / 500 mg) — broad-spectrum benzimidazole anthelmintic with over 50 years of veterinary clinical use. Multi-strength tablets for canine, feline, and small-animal deworming protocols.

Orvosi ellenőrzés Morgan Ellis — Gyógyszerkutató · 8 év tapasztalat  · Utolsó felülvizsgálat: 2026 május

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Quick Answer — What is Wormentel?

Wormentel tartalmaz fenbendazole, a benzimidazole-class broad-spectrum antiparasitic with over 50 years of clinical use in veterinary medicine and emerging use as a human anthelmintic in jurisdictions where albendazole or mebendazole are not available. Available at MedsBase in 222 mg, 444 mg and 500 mg tablets. Fenbendazole is highly effective against intestinal nematodes (roundworms, hookworms, whipworms), cestodes (tapeworms), and several protozoal parasites including Giardia. Standard human dewormer protocols use 222-500 mg once daily for 3 consecutive days, with a repeat course at 14 days for pinworm/threadworm cycles. Fenbendazole has an excellent safety profile — absorption is low, side effects are uncommon and usually mild gastrointestinal. Not for use in pregnancy (benzimidazole class effect — teratogenic in animal studies at high doses).

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What is Wormentel?

Wormentel is a brand of fenbendazole, a benzimidazole-class broad-spectrum anthelmintic (antiparasitic) drug. It is supplied in three tablet strengths: 222 mg, 444 mg and 500 mg. The 222 mg and 444 mg strengths use the same dosing units as the original veterinary product (Panacur), allowing flexible dosing across the wide range of indications and species; the 500 mg strength is convenient for adult human dosing.

Fenbendazole has been in continuous clinical use since the 1970s — primarily as a veterinary anthelmintic in dogs, cats, horses, cattle, sheep, goats, pigs, and zoo animals (where it is one of the most widely used dewormers globally). It is increasingly used in humans in jurisdictions where albendazole or mebendazole supply is intermittent.

Pack sizes available at MedsBase: 30, 60, 90, 200, 400 vagy 800 tabletta.

Regulatory status note: Fenbendazole is not currently licensed for human use in the EU, UK, USA or Australia — albendazole (Zentel) and mebendazole (Vermox) are the licensed benzimidazoles for humans in those jurisdictions. Off-label and over-the-counter human use of fenbendazole is widespread in parts of Asia, South America, and the Indian subcontinent, where the drug has been used safely in human populations for decades.

How fenbendazole works

Fenbendazole binds with high affinity to parasite β-tubulin, blocking microtubule polymerisation in the parasite’s cells. This disrupts the parasite’s ability to absorb glucose from the host gut, causes energy depletion within 24-48 hours, and ultimately kills the parasite. Mammalian (host) tubulin has a much lower affinity for benzimidazoles, which is why these drugs are highly selective and well-tolerated in humans and animals.

Fenbendazole is poorly absorbed from the gastrointestinal tract — oral bioavailability is approximately 1-2% in dogs and humans. This is actually advantageous for an intestinal anthelmintic: high concentrations are maintained in the gut lumen (where the parasites live) while systemic exposure stays low. Taking fenbendazole with a fatty meal increases absorption modestly.

The drug is metabolised in the liver to oxfendazole (the sulfoxide) and a sulfone metabolite, both of which retain anthelmintic activity. Excretion is primarily faecal.

Which parasites Wormentel treats

Established indications:

  • Roundworm (Ascaris lumbricoides) — one of the most common human parasites globally; very high cure rate
  • Hookworm (Ancylostoma duodenale, Necator americanus) — high cure rate
  • Whipworm (Trichuris trichiura) — benzimidazoles are first-line; multi-day course recommended
  • Pinworm / threadworm (Enterobius vermicularis) — very common in children; single dose with repeat at 14 days for the egg-cycle
  • Giliszta (Taenia saginata, Hymenolepis nana) — useful but praziquantel remains first-line for most cestodes
  • Giardiasis (Giardia lamblia / duodenalis) — effective alternative to metronidazole, particularly in metronidazole-resistant cases
  • Strongyloidiasis (Strongyloides stercoralis) — ivermectin remains first-line; benzimidazoles are an alternative
  • Trichostrongyliasis — effective

Veterinary indications (Wormentel is also used by vets and pet owners worldwide):

  • Dogs and puppies: roundworm, hookworm, whipworm, Giardia, Taenia (not Dipylidium)
  • Cats: roundworm, hookworm, lungworm
  • Horses: large/small strongyles, ascarids, pinworms
  • Cattle, sheep, goats, pigs: GI nematodes, lungworms, certain tapeworms

Dosage by indication & strength

Adult human dosing (off-label, follow medical advice):

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Pinworm / threadworm222-500 mg single dose, repeat at 14 days; treat all household members simultaneously
Roundworm (Ascaris)500 mg once daily for 3 days
Kampóféreg500 mg once daily for 3 days
Trichuriasis (Trichuris fertőzés)500 mg once daily for 3 days; longer courses sometimes needed
Mixed intestinal infection500 mg once daily for 3 days
Giardiasis222-500 mg once daily for 3-5 days
Tapeworm (Taenia)500 mg once daily for 3 days; praziquantel preferred when available

Take Wormentel étellel, ideally containing some fat — this modestly increases absorption (which matters for systemic infections; less so for purely intestinal worms).

Gyermekek: paediatric dosing is weight-based (typically 5-10 mg/kg/day). For children under 6 or weighing under 20 kg, dosing should be supervised by a paediatrician — mebendazole or albendazole at licensed paediatric doses are usually preferred.

Veterinary use (general guidance — consult your vet for species-specific dosing): dogs and cats are typically dosed at 50 mg/kg once daily for 3-5 consecutive days. The 222 mg tablet is convenient for dogs around 4-5 kg (one tablet/day); the 500 mg tablet for dogs around 10 kg. Always weigh the animal and dose accurately.

Mellékhatások és biztonság

Fenbendazole has an excellent safety profile in both humans and animals. Side effects are uncommon and usually mild:

  • Gyakori (1 a 100-ból): mild abdominal discomfort, transient nausea, diarrhoea (often related to die-off of intestinal parasites)
  • Nem gyakori: headache, dizziness, mild rash
  • Ritka: elevated liver enzymes (transient, monitored if courses are prolonged), neutropenia (very rare, generally with prolonged high-dose courses)
  • Nagyon ritkán: Stevens-Johnson syndrome (class effect of benzimidazoles)

Note that mild GI symptoms in the first 1-3 days of treatment often reflect parasite die-off (release of antigens) rather than drug toxicity. They typically settle as treatment continues.

Ellenjavallatok és figyelmeztetések

Do not take Wormentel if:

  • You are pregnant or planning pregnancy — benzimidazoles are teratogenic in animal studies; avoid in the first trimester especially. If treatment of a parasitic infection is essential, the decision should be made by an obstetrician or infectious disease specialist.
  • You have known hypersensitivity to fenbendazole or other benzimidazoles (mebendazole, albendazole)
  • You have severe hepatic impairment

Óvatosan használja, ha rendelkezik a következőkkel:

  • Mild-to-moderate hepatic impairment — monitor liver enzymes if treatment exceeds a few days
  • Bone marrow suppression or are on chemotherapy — benzimidazoles can cause neutropenia at high doses

Szoptatás: there is limited data on fenbendazole excretion into breast milk. Mebendazole or albendazole have more breastfeeding safety data and are preferred for nursing mothers.

Gyógyszerkölcsönhatások

  • Cimetidine — increases fenbendazole levels by inhibiting hepatic metabolism. Effect is generally beneficial (used clinically to boost absorption for systemic indications).
  • Dexamethasone — can increase plasma concentration; sometimes used clinically.
  • CYP enzyme inducers (carbamazepine, phenytoin, rifampicin) — reduce fenbendazole levels.
  • Other anthelmintics — do not combine multiple anthelmintics without medical supervision; co-administration can increase toxicity without improving cure.

Fenbendazole vs albendazole vs mebendazole

All three are benzimidazoles with the same fundamental mechanism (β-tubulin binding) and broadly overlapping spectra. Practical differences:

JellemzőFenbendazole (Wormentel)AlbendazoleMebendazole
Human licensureVeterinary; off-label human use widespread in Asia / South AmericaWorldwide human licensureWorldwide human licensure
BioavailabilityLow (1-2%) — gut-luminal actionHigher with food (5-15%)Low (5-10%)
Legjobb választásIntestinal worms, Giardia, broad veterinary useTissue parasites (neurocysticercosis, hydatid)Intestinal worms (paediatric standard)
TerhességKerüljeKerüljeAvoid (esp. T1)

Other Wormentel-relevant pages on this site: Albendazole 400 mg (ABD-400), Ivermectin (Iverheal), Ivermectin (Iverjohn), Fenever (oral fenbendazole suspension for dogs & cats).

Tárolás és eltarthatóság

Store Wormentel below 25°C in the original blister pack. Protect from moisture and direct sunlight. Keep out of reach of children. Do not use after the expiry date printed on the carton.

Gyakran Ismételt Kérdések

Is Wormentel safe for humans?

Fenbendazole has a long safety record in humans in jurisdictions where it has been used as an anthelmintic for decades. It is not currently licensed for human use in the EU, UK, USA or Australia — in those countries albendazole or mebendazole are the licensed benzimidazoles. The pharmacology is similar across the class and the safety profile is broadly comparable.

How quickly does Wormentel kill worms?

Fenbendazole disrupts parasite metabolism within hours of dosing; the parasites die over 24-72 hours. You may see worms passed in stool over the next several days. Mild GI symptoms in the first 1-3 days often reflect parasite die-off rather than drug side effects.

Why do I need to repeat the dose at 14 days for pinworm?

Pinworm (threadworm) eggs survive for up to 2 weeks on bedding, clothing, and surfaces, and can re-infect the host. The single-dose treatment kills the adult worms in the gut but does not destroy the egg pool in the environment. Repeating at 14 days catches any re-infection from the egg cycle. All household members should be treated simultaneously to avoid re-introduction.

Can I give Wormentel to my dog or cat?

Yes — fenbendazole is one of the most widely used canine and feline dewormers globally and is the active ingredient in Panacur. Standard dose is 50 mg/kg once daily for 3-5 days. The 222 mg and 500 mg strengths are convenient for the most common dog weight ranges. Always weigh the animal and dose accurately, and consult your vet for any animal younger than 6 weeks, pregnant, or with underlying disease.

Can I take Wormentel during pregnancy?

No — benzimidazoles are teratogenic in animal studies and should be avoided during pregnancy, especially in the first trimester. If you have a parasitic infection during pregnancy, see an obstetrician or infectious disease specialist; sometimes treatment is deferred until after delivery, sometimes a non-benzimidazole option (such as pyrantel pamoate) is used instead.

Do I need to fast or change my diet to take Wormentel?

No — Wormentel is taken with food, ideally a meal containing some fat which modestly improves absorption. There is no need to fast, take laxatives, or follow any special diet around dosing.

Will Wormentel show up on a drug test?

No — fenbendazole is not detected by routine drug-of-abuse screening, occupational drug testing, or doping/anti-doping panels.

What strength should I order?

For human use, the 500 mg tablet is the most convenient adult unit dose. The 222 mg és 444 mg tablets correspond to original veterinary dosing units and are useful when treating animals or when titration is needed (small dogs, paediatric, sensitive patients). If unsure, the 500 mg pack is the standard adult choice.

Can I combine Wormentel with ivermectin or albendazole?

Combination anthelmintic therapy is sometimes used in mass deworming programmes (ivermectin + albendazole for lymphatic filariasis; ivermectin + benzimidazole for soil-transmitted helminth control). For routine self-treatment, combining anthelmintics is not recommended without medical supervision — one drug at a time, then assess response.

Where can I order Wormentel online?

You can order Wormentel 222 mg, 444 mg or 500 mg tablets from MedsBase in pack sizes of 30 to 800 tablets. Orders ship worldwide with discreet packaging. If you are uncertain whether fenbendazole is the right anthelmintic for your situation, consult your doctor, pharmacist, or veterinarian first.

⚕ Orvosi nyilatkozat. Ez az oldal csak tájékoztató jellegű, és nem helyettesíti a képzett egészségügyi szakember tanácsát. Mindig olvassa el a gyógyszerhez mellékelt betegtájékoztatót, és konzultáljon az orvosával vagy gyógyszerészével bármilyen kezelés megkezdése, módosítása vagy leállítása előtt. A MedsBase nem nyújt diagnózist, receptet vagy klinikai ajánlásokat.

Miért rendelj a MedsBase-ról

Wormentel is supplied from a WHO-GMP tanúsított gyártó, szállítja, diszkréten csomagolva, világszerte. Minden rendelést fedez a Újraküldési Garancia – Ön soha nem viseli el az elveszett csomag költségét.

Lásd még: Iverheal + Wormentel multi-agent pack — Iverheal 12 mg párosítva Wormentel 222 mg-gal protokollvezérelt, többagens féreghajtó kezeléshez.

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222 mg, 444 mg, 500 mg

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30 tabletta, 60 tabletta, 90 tabletta, 200 tabletta, 400 tabletta, 800 tabletta

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