Malegra DXT

📦 Hver ordre er dekket av vår Reshipment Assurance Policy — hvis pakken din ikke ankommer innen 20 virkedager, sender vi ny.

Hvorfor bestille fra MedsBase

Våre generiske legemidler kommer fra WHO-GMP-sertifiserte produsenter og sendes over hele verden i diskret, nøytral emballasje — ingen legemiddelnavn på utsiden av pakken. Kortbetalinger håndteres av en regulert betalingsbehandler (kontoutskrifter viser en regulert kortbetalingsprosessor — aldri “MedsBase” eller noe legemiddelnavn). Krypto og SEPA bankoverførsel godtas også. Hver ordre er dekket av vår Reshipment Assurance Policy.

Malegra DXT combines sildenafil 100 mg (a short-acting PDE5 inhibitor for erectile dysfunction) with duloxetine 30 mg (an SNRI — serotonin-norepinephrine reuptake inhibitor — that delays ejaculation). Unlike dapoxetine (engineered for on-demand PE use), duloxetine is a daily-use SNRI where the ejaculation-delay effect builds over 2–4 weeks of continuous dosing.

Manufactured by Sunrise Remedies, Malegra DXT is intended for men with samtidig ED og PE who tolerate or specifically prefer SNRI-based therapy over SSRI alternatives.

What Is Malegra DXT?

Malegra DXT is a combination tablet containing:

• Sildenafil 100 mg — a PDE5 inhibitor; improves erectile response, effects last 4–6 hours
• Duloxetine 30 mg — an SNRI; extends ejaculatory latency when taken daily for 2–4+ weeks

Viktig: duloxetine is not an on-demand PE drug. It requires continuous daily dosing to reach steady-state pharmacology. The PE-delay benefit builds gradually and stops when you stop — it is also not FDA-approved specifically for PE (use is off-label). For on-demand PE, a dapoxetine-based combination such as Super P-Force eller Super Tadarise is more practical.

How Does Malegra DXT Work?

• Sildenafil blocks PDE5 in the corpus cavernosum, extending cyclic GMP activity and allowing increased blood inflow during sexual arousal
• Duloxetine inhibits both serotonin and norepinephrine reuptake. The raised synaptic serotonin delays the ejaculatory reflex; the norepinephrine component gives duloxetine a more “activating” profile than pure SSRIs

Duloxetine has a half-life of ~12 hours, substantially shorter than fluoxetine (active metabolite persists 7–15 days). Steady-state concentration is reached in 3–4 days, but the clinical PE-delay effect typically takes 2–4 weeks to stabilise.

Sildenafil vs Duloxetine vs Dapoxetine — Why the Combination Matters

Bruk og indikasjoner

• Samtidig ED og PE where daily SNRI therapy is acceptable
• PE with mood, anxiety, or chronic-pain overlap — duloxetine is also FDA-approved for generalized anxiety, diabetic peripheral neuropathy, fibromyalgia, and chronic musculoskeletal pain
• Men who did not respond well to SSRIs and want SNRI cover instead

Malegra DXT Dosage and Administration

How to Take Malegra DXT Properly

• Swallow the tablet whole with water — can be taken with or without food; a heavy fatty meal slows sildenafil onset slightly
• For sustained PE benefit, take daily at roughly the same time (build-up phase = 2–4 weeks)
• For ED benefit on any given day, take 25–60 min before anticipated activity
• Do not exceed one tablet per 24 hours
• Do not combine with MAOIs — 14-day washout required before starting; 5 days required after stopping duloxetine before starting an MAOI
• Do not stop abruptly after several weeks of use — taper over 2 weeks to reduce discontinuation syndrome (dizziness, headache, nausea, electric-shock sensations, insomnia). Duloxetine has a shorter half-life than fluoxetine, so discontinuation symptoms are more pronounced
• Avoid alcohol — amplifies hepatic risk and sedation

Side Effects of Malegra DXT

Key safety note: duloxetine carries a class-of-antidepressant warning for transient increase in suicidal thoughts, particularly in young adults (<25) during the first weeks. Regular contact with a prescriber during initiation is essential. Also a well-documented risk of hepatotoxicity — avoid with heavy alcohol use, pre-existing liver disease, or chronic hepatitis.

Advarsler og forholdsregler

• Kardiovaskulær form for seksuell aktivitet — seksuell aktivitet krever hjertefunksjon. Menn med aktiv angina, nylig hjerteinfarkt (innen 90 dager), ukontrollert arytmi eller alvorlig hjertesvikt bør få en hjerteundersøkelse før de starter med en PDE5-hemmer
• Blodtrykk — PDE5-hemmere forårsaker milde, kortvarige reduksjoner i blodtrykk; bruk med forsiktighet hvis du tar flere blodtrykksmedikamenter
• Priapisme — høyere risiko hos menn med sigdcelleanemi, myelomatose eller leukemi; søk akutt behandling hvis en ereksjon varer mer enn 4 timer
• Syn — avbryt og søk vurdering hvis plutselige synsendringer oppstår; sjeldne tilfeller av ikke-arterittisk anterior iskemisk optisk nevropati (NAION) er rapportert
• Hørsel — sjeldne rapporter om plutselig sensorineural høretap — stopp og konsulter en lege hvis du opplever dette
• Alkohol — betydelig alkoholinntak kombinert med enhver PDE5-hemmer kan forverre svimmelhet, hodepine og lavt blodtrykk
• Grapefruktjuice — hemmer CYP3A4 og kan øke blodnivået

Kontraindikasjoner — Hvem bør IKKE ta dette legemiddelet

• Samtidig bruk av nitrater — GTN, isosorbidmono/dinitrat, nikorandil, amylnitritt (“poppers”)
• Samtidig bruk av guanylatcyklase-stimulatorer som f.eks. riociguat
• Nylig hjerteinfarkt (innen 90 dager), ustabil angina eller angina under samleie
• NYHA klasse II eller høyere hjertesvikt de siste 6 månedene
• Ukontrollert arytmi, hypotensjon (blodtrykk 170/100)
• Slag innen de siste 6 månedene
• Kjent ikke-arteritt forreste iskemiske optikusnevropati (NAION) i ett eller begge øyne
• Alvorlig leversvikt (Child-Pugh C)
• Overfølsomhet for virkestoffet eller noe av hjelpestoffene

Legemiddelinteraksjoner

Del alltid en fullstendig liste over dine nåværende medikamenter, inkludert reseptfrie produkter, rekreasjonsdop og urtemedisiner, med legen din før du starter med dette legemiddelet.

Hva du skal gjøre ved overdose

Symptomer på en PDE5-overdose inkluderer kraftig hodepine, markert hypotensi, svimmelhet, rygg- eller muskelvondt og vedvarende ereksjon. Behandlingen er støttende, med væsketerapi og hjerteovervåkning. Kontakt din lokale giftinformasjon eller akuttmottak umiddelbart hvis en overdose mistenkes.

Oppbevaringsinstruksjoner

• Oppbevares under 30 °C på et tørt sted, unna direkte sollys
• Oppbevares i original blistreemballasje til bruk
• Holdes utilgjengelig for barn og kjæledyr
• Ikke bruk etter utløpsdatoen angitt på pakningen
• Kasser ubrukte tabletter via apotekets retursystem der dette er tilgjengelig

Relaterte alternativer på MedsBase

Leter du etter relaterte behandlingsalternativer for ED eller seksuell helse?

• Modula — tadalafil 5 mg, ideell for en gang daglig lavdosebehandling
• Vidalista — Centurion Labs tadalafil, 2,5 til 80 mg
• Tadacip — Cipla tadalafil 20 mg
• Megalis — Macleods tadalafil 10 mg / 20 mg
• Suhagra — Cipla sildenafil 25/50/100 mg
• Se alle behandlinger for erektil dysfunksjon →

Vanlige spørsmål

Is Malegra DXT on-demand or daily?

Mixed. The sildenafil component is on-demand (per-tablet ED effect). The duloxetine component is daily, requiring 2–4 weeks to build steady-state PE-delay effect. Duloxetine is NOT a single-dose PE drug — a one-off tablet won’t delay ejaculation meaningfully.

Why use duloxetine instead of dapoxetine?

Dapoxetine is engineered for on-demand PE use with a short half-life. Duloxetine is an SNRI that also treats anxiety, chronic pain, and depression — so it can make sense for men with overlapping issues. For isolated PE, dapoxetine is usually simpler. For PE + chronic pain or PE + anxiety, duloxetine may solve two problems at once.

How is duloxetine different from fluoxetine?

Fluoxetine is an SSRI (serotonin only) with a very long half-life (active metabolite 7–15 days). Duloxetine is an SNRI (serotonin + norepinephrine) with a shorter half-life (~12 h). Duloxetine is more “activating” (energising effect from the norepinephrine component) and has clearer data for chronic pain and anxiety. Fluoxetine has a gentler discontinuation profile because of its long tail.

When does the PE-delay effect start?

Duloxetine usually requires 2–4 uker of daily dosing for full effect; some men notice partial improvement within 1–2 weeks. If you expect immediate relief from the first tablet, this product will disappoint — consider a dapoxetine-based combination instead.

How long does the sildenafil effect last?

4–6 hours per tablet, as with any sildenafil product.

Can I take Malegra DXT with alcohol?

Avoid regular drinking. Duloxetine + alcohol amplifies hepatotoxicity risk — this is not a theoretical concern; duloxetine is specifically contraindicated with chronic alcohol use. Occasional single drinks are less risky but should still be discussed with a clinician.

Does duloxetine cause sexual side effects?

Yes — delayed orgasm is one of duloxetine’s documented effects, which is also the mechanism of its PE benefit. In some men this becomes excessive (anorgasmia) and may require dose reduction. Erectile function itself is usually preserved or enhanced by the sildenafil component.

Can I stop Malegra DXT abruptly?

Nei. Duloxetine discontinuation syndrome is more pronounced than with fluoxetine because of the shorter half-life. Taper over at least 2 weeks under medical supervision. Symptoms of too-fast taper include dizziness, nausea, insomnia, anxiety, headache, and electric-shock sensations.

Is Malegra DXT safe for men with heart conditions?

Nei if you use nitrates, have had a recent MI, or have unstable angina — sildenafil is contraindicated. Duloxetine may also modestly raise blood pressure via its norepinephrine effect. Cardiac review and careful selection are required.

Can I take Malegra DXT if I’m already on another antidepressant?

Usually no. Combining duloxetine with other serotonergic drugs (SSRIs, other SNRIs, MAOIs, some migraine drugs, tramadol, some opioids) risks serotonin syndrome. Switching antidepressants requires a washout and medical supervision.

What about liver problems?

Duloxetine is hepatically cleared and can cause hepatotoxicity. Avoid if you have hepatic impairment, chronic hepatitis, or heavy alcohol use. Stop and seek medical advice if you develop yellow skin/eyes, right upper abdominal pain, or severe fatigue.

What if Malegra DXT doesn’t work for my PE after 4 weeks?

Options: increase duloxetine dose (requires medical supervision), switch to a dapoxetine-based combination, add behavioural therapy (stop-start / squeeze technique), or try topical anaesthetics under medical guidance. Persistent PE warrants clinical review — it can sometimes reflect anxiety, thyroid issues, or prostate inflammation.

Malegra DXT pairs sildenafil 100 mg with duloxetine 30 mg, a short-half-life SNRI alternative for ED-plus-PE; users who would rather use the longer-half-life fluoxetine SSRI route can switch to Malegra FXT (sildenafil 100 mg + fluoksetin 40 mg) within the same Sunrise Remedies brand range.

Relaterte alternativer

Andre produkter innen Menns helse som kunder også ser på:

• Sildisoft
• Himcolin Gel
• Clomiford
• Minoxytop (Minoxidil)
• Sildenafil Tablets USP

Flere alternativer i behandling av tidlig utløsning

Rangert etter nylig bestillingsvolum på MedsBase — hva andre kunder i denne kategorien velger.

Super Vilitra

US$19.50 – US$220.00Preisspanne: US$19.50 bis US$220.00

Vriligy

US$19.00 – US$210.00Preisspanne: US$19.00 bis US$210.00

Extra Super P Force

US$12.50 – US$224.00Preisspanne: US$12.50 bis US$224.00

Extra Super Tadarise

US$18.00 – US$204.00Preisspanne: US$18.00 bis US$204.00