Theo-Asthalin
✅ Effective asthma symptom control
✅ Rapid bronchospasm relief
✅ Improved lung function
✅ Enhanced quality of life
Contains Salbutamol and Theophylline
✓ Medisinsk vurdert av Morgan Ellis — Farmasøytisk forsker · 8 års erfaring · Sist gjennomgått: mai 2026
⚡ Quick Answer — What is Theo-Asthalin?
Theo-Asthalin inneholder theophylline + salbutamol, en methylxanthine bronchodilator with anti-inflammatory effects, used as add-on therapy for chronic asthma and COPD. Theophylline acts on multiple targets — phosphodiesterase inhibition (raising cAMP), adenosine receptor antagonism, and HDAC2 activation (anti-inflammatory). It has a narrow therapeutic index (target serum 10–20 mg/L; toxicity at 20+) and many drug interactions, requiring careful dosing and (in some patients) blood-level monitoring. Each tablet contains theophylline 100 mg + salbutamol 2 mg, produsert av Cipla at WHO-GMP certified facilities.
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What Is Theo-Asthalin?
Theo-Asthalin is an oral methylxanthine bronchodilator. Methylxanthines are derived from natural alkaloids (theophylline is the dimethylxanthine present in tea). Their use has declined since the 1990s as inhaled β2-agonists and corticosteroids became first-line — but they retain a role as third-line add-on therapy in difficult asthma and COPD.
How Does Theo-Asthalin Work?
- Phosphodiesterase inhibition (PDE3, PDE4) — raises cyclic AMP in airway smooth muscle and inflammatory cells; net result is bronchodilation and reduced mediator release.
- Adenosine receptor antagonism — blocks adenosine-mediated bronchoconstriction and mast-cell mediator release.
- HDAC2 activation (theophylline at low serum levels 5–10 mg/L) — restores corticosteroid responsiveness in COPD and severe asthma where steroid resistance is partly mediated by reduced HDAC2.
- Diaphragm contractility — methylxanthines reduce diaphragm fatigue, useful in COPD with severe airflow limitation.
Bruk og indikasjoner
- Severe chronic asthma — add-on to high-dose ICS-LABA where additional bronchodilation is needed
- COPD maintenance — add-on to LAMA-LABA or triple therapy
- Nocturnal asthma — sustained-release formulation provides overnight bronchodilation
- Apnoea of prematurity (theophylline) — neonatal use
- Cor pulmonale and pulmonary hypertension — adjunct
Theo-Asthalin Dosage
| Patient | Dose | Frekvens |
|---|---|---|
| Adults | 1 tablett | Three to four times daily |
| Children >12 yr | 1 tablett | Three times daily |
Side Effects of Theo-Asthalin
- Nausea, vomiting, dyspepsia
- Hodepine
- Tremor
- Insomnia, restlessness
- Tachycardia, palpitations
- Mild hypokalaemia at high doses
Toxic levels (>20 mg/L) — emergency:
- Severe nausea, persistent vomiting
- Cardiac arrhythmia (atrial fibrillation, supraventricular tachycardia)
- Seizures (often without warning)
- Hypotension, hyperglycaemia, hypokalaemia, hypercalcaemia
Advarsler og forholdsregler
- Narrow therapeutic index. Target serum 10–20 mg/L. Check blood level 5 days after starting, after dose change, with new interacting drug, with smoking cessation, and during illness/fever (clearance falls).
- Many drug interactions — see interactions table. Most metabolised by CYP1A2; many inhibitors and inducers shift levels significantly.
- Smoking induces CYP1A2 and lowers theophylline levels by ~50% — re-titrate at smoking cessation.
- Cardiac disease: use cautiously in arrhythmias, heart failure, severe hypertension.
- Hyperthyroidism: increased clearance plus exaggerated adrenergic effects.
- Graviditet og amming: generally avoided; use only if benefit clear.
- Liver disease: reduce dose — methylxanthines are hepatically metabolised.
Kontraindikasjoner
- Hypersensitivity to theophylline or other xanthines (caffeine, theobromine)
- Aktiv magesårlidelse
- Uncontrolled tachyarrhythmias
- Severe heart failure (NYHA IV)
Legemiddelinteraksjoner
| Interacting drug | Effekt | Hva du bør gjøre |
|---|---|---|
| Ciprofloxacin, erythromycin, clarithromycin, fluvoxamine | Inhibit CYP1A2 → raise theophylline levels → toxicity (nausea, arrhythmia, seizures) | Avoid or reduce theophylline dose 50%; check serum levels |
| Cimetidine, allopurinol | Raise theophylline levels | Reduce dose; monitor levels |
| Phenytoin, carbamazepine, rifampicin | Induce CYP — lower levels | Higher dose may be needed |
| Smoking | Induces CYP1A2 — lower levels | Re-titrate dose at smoking cessation |
| β-agonists, diuretics | Additive hypokalaemia | Monitor potassium |
Oppbevaring
- Store below 25°C in a cool, dry place away from direct sunlight.
- Keep in original packaging until use to protect from moisture and light.
- Do not use after the expiry date printed on the strip.
- Keep out of reach of children.
Relaterte alternativer på MedsBase
- Asthalin Inhaler — salbutamol reliever
- Budecort Inhaler — budesonide ICS preventer
- Foracort Inhaler — budesonide + formoterol ICS-LABA
- Tiova Inhaler — tiotropium LAMA for COPD
- Montair — montelukast LTRA tablet
Vanlige spørsmål
Why combine theophylline with salbutamol?
The combination delivers β2 agonism (bronchodilation) plus methylxanthine effect (additional bronchodilation, anti-inflammatory, diaphragm contractility) in one tablet — historically convenient for compliance.
Is this combination still used?
Less commonly than separate components. Modern practice prefers inhaled therapy (β2 agonist + ICS) over oral combinations, both for safety (lower systemic exposure) and efficacy.
Are the side effects of both drugs additive?
Yes — tremor, tachycardia, headache, insomnia, hypokalaemia are amplified by both components. Monitor cardiovascular tolerance.
How fast does Theo-Asthalin start working?
Salbutamol component begins in 15–30 min; theophylline reaches steady state over days.
Can I take it with my inhaler?
Possibly — discuss with your prescriber. Stacking oral and inhaled β2-agonists can increase tremor, tachycardia, and hypokalaemia.
Will it interact with my heart medications?
Theophylline interacts with many drugs (see interaction table). Always tell your doctor what you are taking.
Is it safe in pregnancy?
Generally avoided; inhaled therapy is preferred.
How long does each tablet last?
Both components last 4–6 hours; dosing 3–4 times daily.
Can I crush the tablet?
Standard tablets can be crushed; controlled-release versions cannot. Check the label.
Relaterte alternativer
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Rangert etter nylig bestillingsvolum på MedsBase — hva andre kunder i denne kategorien velger.
| Styrke | 2mg + 100mg, 4mg + 200mg |
|---|---|
| Antall | 30 Tablett/er, 60 Tablett/er, 90 Tablett/er |
| Farmasøytisk form | Tablet/t |
| Produsent | Cipla Inc |
| Behandling | Asthma |
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