Busiron
Busiron (Buspirone 5/10 mg) — 5-HT1A partial agonist for generalised anxiety disorder. non-sedating, non-addictive — slow onset 3–6 weeks.
✓ Medisinsk vurdert av Morgan Ellis — Farmasøytisk forsker · 8 års erfaring · Sist gjennomgått: mai 2026
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Busiron (Buspirone 5 / 10 mg) is a 5-HT1A partial agonist for generalised anxiety disorder. Non-sedating, non-addictive, no abuse potential — but slow onset (3–6 weeks). Useful when benzodiazepines are inappropriate.
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Hvorfor bestille fra MedsBase
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What Busiron is and how it works
Busiron is a 5 / 10 mg buspirone tablet supplied by Intas. Buspirone is a partial agonist at 5-HT1A serotonin receptors and a weak D2 antagonist. The 5-HT1A action reduces anxiety over weeks of dosing; the absence of GABA-A interaction explains why buspirone produces neither sedation, nor amnesia, nor dependence — distinguishing it sharply from benzodiazepines.
Buspirone takes 3–6 weeks to reach full anxiolytic effect. It does not work as a PRN agent and does not produce immediate calming. Patients who expect benzodiazepine-like relief in the first week will conclude buspirone “doesn’t work” and stop. Set the expectation up front.
Indikasjoner og dosering
| Indikasjon | Startdose | Måldose | Maks |
|---|---|---|---|
| Generalised anxiety disorder | 5 mg BID–TID | 20–30 mg/day in 2–3 doses | 60 mg |
| SSRI sexual dysfunction (off-label) | 10 mg BID | 20 mg BID | — |
| Older adults | 5 mg BID | 15–20 mg/day | — |
Take consistently with or without food (food reduces variability). Avoid grapefruit juice (CYP3A4 inhibition).
Viktige sikkerhetshensyn
Buspirone is heavily CYP3A4-metabolised. Strong inhibitors (clarithromycin, itraconazole, ketoconazole, ritonavir, grapefruit juice) raise levels 5–10× — start at 2.5 mg BID. Strong inducers (rifampicin, carbamazepine, phenytoin, St John’s wort) reduce levels and may abolish efficacy.
14-day washout each direction; concurrent use risks hypertensive crisis.
Buspirone is a Schedule-uncontrolled medication in all major regulatory zones. It produces no euphoria, no tolerance, no withdrawal, and is well-suited to patients with substance-use history or those who must avoid impairment (drivers, pilots, machine operators, surgeons).
Vanlige bivirkninger
- Vanlig: dizziness, headache, nausea, nervousness — usually mild and transient.
- Mindre vanlige: drowsiness (less than benzodiazepines), restlessness, paraesthesias.
- No significant: sedation, dependence, sexual dysfunction, weight gain, cognitive impairment.
Graviditet, amming, pediatri
Pregnancy category B; safer profile than benzodiazepines for pregnant patients with anxiety. Breastfeeding: limited data; usually compatible. Paediatric: not first-line; off-label use described.
Oppbevaring
Oppbevar ved 15–30 °C i originalemballasje.
Vanlige spørsmål
How is Busiron different from a benzodiazepine?
Buspirone acts on 5-HT1A receptors, not GABA-A — completely different mechanism. The clinical translation: no sedation, no amnesia, no dependence, no withdrawal, no abuse potential, no immediate effect. Buspirone is for chronic GAD; benzodiazepines are for acute anxiety crisis or short-term use.
Why is Busiron dosed two or three times daily?
Short half-life (~2.5 hours) and saturable first-pass metabolism mean steady-state plasma levels need divided dosing. Once-daily formulations exist but are uncommon.
How long until Busiron works?
Some patients notice subtle effects in week 2; the full anxiolytic effect takes 3–6 weeks at a stable dose. If anxiety is unchanged at 6 weeks of 20 mg/day, increase or switch.
Can Busiron be used PRN for panic attacks?
No — buspirone has no acute anxiolytic effect. For PRN anxiety, propranolol or hydroxyzine (or, with appropriate caution, a benzodiazepine) are clinically appropriate. Buspirone is for chronic GAD only.
Can Busiron be combined with an SSRI?
Yes — common combination, particularly for SSRI augmentation in partial-response anxiety or depression, and for SSRI sexual side-effect mitigation. The combination is well-tolerated.
Will Busiron make me drowsy?
Mild drowsiness is reported but is much less than benzodiazepines or sedating antihistamines. Most patients drive and work normally on buspirone.
Can I stop Busiron abruptly?
Yes — buspirone produces no withdrawal syndrome. Some clinicians taper over 1–2 weeks out of caution but it is not pharmacologically required.
Can Busiron be used in older adults?
Yes — favourable profile in older adults compared to benzodiazepines (no fall risk, no cognitive impairment). Start at lower doses (5 mg BID) because of variable hepatic clearance.
Why avoid grapefruit juice?
Grapefruit juice strongly inhibits intestinal CYP3A4. Buspirone bioavailability normally ranges 4–10% (high first-pass metabolism); grapefruit juice can raise it 10-fold, producing dose-dumping and sedation/dizziness.
Is Busiron addictive?
No — no abuse potential, no dependence, no withdrawal. This is one of buspirone’s key clinical advantages.
Andre psykofarmaka
- Atarax (Hydroxyzine — sedating PRN anxiolytic)
- Lexaheal (Escitalopram — first-line GAD)
- Pexep (Paroxetine — first-line GAD)
- Duvanta (Duloxetine SNRI — GAD)
- Mirtaz (Mirtazapine — depression with anxiety)
Flere alternativer innen psykisk helse og psykofarmaka
Rangert etter nylig bestillingsvolum på MedsBase — hva andre kunder i denne kategorien velger.
| Styrke | 5 mg, 10 mg |
|---|---|
| Antall | 30 tabletter, 60 tabletter, 90 tabletter, 180 tabletter |
Busiron
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Busiron
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