Aten
Aten is Ipca Laboratories’ atenolol 25/50/100 mg tablets — cardioselective beta-1 adrenergic blocker introduced by ICI in 1976 as Tenormin. 6-9 hour half-life, largely renally cleared. Primary uses: hypertension (now second-line per most guidelines after LIFE trial showed inferiority to losartan in stroke prevention), chronic stable angina, atrial fibrillation rate control, post-MI secondary prevention. Cardioselectivity makes it tolerable in mild asthma where non-selective beta-blockers are problematic, though not risk-free.
✓ Verificat medical de Morgan Ellis — Cercetător farmaceutic · 8 ani de experiență · Ultima recenzie: mai 2026
⚡ Quick Answer — What is Aten?
Aten este un 25 / 50 / 100 mg atenolol immediate-release tablet from Ipca Laboratories — cardioselective (beta-1). Primary use is hypertension; also used for angina, arrhythmia control, post-myocardial-infarction secondary prevention, though atenolol-based hypertension therapy has inferior outcomes vs ACE-/ARB-/CCB-based regimens (LIFE trial) — now a second-line BP drug. Typical hypertension dose: 25-100 mg once daily. Contraindicated in asthma (relative for cardioselective agents; absolute for non-selective), severe bradycardia, second/third-degree heart block, acute decompensated heart failure, and phaeochromocytoma without prior alpha-blockade. Do NOT stop abruptly — taper over 1-2 weeks to avoid rebound tachycardia / angina / MI.
📦 Fiecare comandă este acoperită de politica noastră de Politica noastră de Reexpediere Garantată — dacă coletul dumneavoastră nu sosește în 20 de zile lucrătoare, îl relivrăm.
De ce să comanzi de la MedsBase
Medicamentele noastre generice sunt procurate de la producători certificați WHO-GMP și expediate la nivel mondial în ambalaje discrete și simple — fără denumirea medicamentului pe exteriorul coletului. Plățile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de plăți cu card reglementat — niciodată “MedsBase” sau numele vreunui medicament). Acceptăm și criptomonede și transferuri bancare SEPA. Fiecare comandă este susținută de Politica noastră de Asigurare pentru Relivrare.
What Is Aten?
Aten is an oral immediate-release tablet containing atenolol 25 / 50 / 100 mg from Ipca Laboratories, supplied in 28-84 tablets. Atenolol is a cardioselective (beta-1). Introduced 1976 as one of the first cardioselective beta-blockers. Once a first-line antihypertensive, now generally relegated to a second-line agent — the LIFE trial (2002) and subsequent meta-analyses showed atenolol-based hypertension therapy produced inferior reductions in stroke, MI, and total mortality compared with ARB-, ACE-inhibitor-, and CCB-based regimens. Still widely used for angina, rate control, and arrhythmia suppression.
How Atenolol Lowers Blood Pressure
Beta-blockers reduce blood pressure through four mechanisms:
- Reduction of cardiac output — beta-1 blockade in the sinoatrial node reduces heart rate, and blockade in ventricular myocardium reduces contractility. Lower cardiac output = lower blood pressure.
- Renin-angiotensin suppression — beta-1 blockade in juxtaglomerular cells reduces renin release, lowering angiotensin II and aldosterone over 2-4 weeks. This accounts for much of the long-term BP effect.
- Central sympathetic reduction — lipophilic beta-blockers cross the blood-brain barrier and reduce central sympathetic outflow.
Beta-blockers are hydrophilic — minimal CNS penetration; one of the reasons it is poorly effective for migraine prevention (vs propranolol) but causes fewer CNS side effects (less fatigue, vivid dreams, depression). Plasma half-life of atenolol is 6-7 hours (renal excretion).
Approved and Evidence-Based Uses
- Hypertension (primary indication)
- Stable angina — remains first-line for symptomatic relief
- Atrial fibrillation rate control
- Supraventricular tachycardia
- Post-MI — evidence slightly weaker than metoprolol / carvedilol / bisoprolol
- Thyrotoxicosis — symptom control
- Situational anxiety — low-dose for performance anxiety (though propranolol is preferred for CNS penetration)
Aten Dosage
Adult hypertension dose: 25-100 mg once daily.
Start low, titrate upward over 2-4 weeks to target BP (typically <140/90 in uncomplicated hypertension; <130/80 in diabetes, chronic kidney disease, or established cardiovascular disease). Check resting pulse before each dose-increase — do not titrate if <55 bpm.
Monitorizare:
- Resting pulse and BP at 2, 4, and 8 weeks after starting or dose change
- Baseline ECG if any cardiac history; periodic ECG if symptoms change
- Renal function (atenolol is renally excreted; dose reduction in eGFR <35)
Administration: swallow whole with water. Take at approximately the same time each day.
Discontinuation: NEVER stop abruptly. Taper over 1-2 weeks (reduce by 25-50% every 3-5 days). Abrupt discontinuation causes rebound tachycardia, worsened angina, and — in patients with coronary disease — can precipitate myocardial infarction. This is one of the most important safety points for beta-blockers.
Efecte Secundare
Common (>5%):
- Fatigue, lethargy — often adapts over 2-4 weeks
- Cold hands and feet (peripheral vasoconstriction)
- Bradycardia (check pulse; stop if <50 bpm)
- Exercise intolerance — maximum heart rate is blunted by beta blockade
- Dizziness, postural hypotension
- Minimal CNS effects (hydrophilic)
- Reduced libido, erectile dysfunction (mostly at higher doses)
Mai puțin frecvente: depression, reduced libido / erectile dysfunction, gastrointestinal upset, Raynaud-like cold intolerance, bronchospasm (more common with non-selective agents).
Important but uncommon:
- Masked hypoglycaemia in diabetics — beta-blockers blunt the tachycardia / tremor warning signs of low blood sugar. Monitor glucose more carefully; prefer nebivolol sau bisoprolol in insulin-treated diabetes.
- Bronchospasm — can be severe in asthma / COPD. Absolute contraindication for non-selective agents; relative for cardioselective.
- Heart block or worsening heart failure — in susceptible patients. Start low, titrate slowly.
Contraindications & Cautions
- Severe asthma / severe COPD — relative contraindication (cardioselectivity is relative, not absolute)
- Second or third-degree atrioventricular block (without pacemaker)
- Sinus bradycardia <50 bpm
- Cardiogenic shock, decompensated heart failure requiring inotropes
- Severe peripheral arterial disease, Raynaud’s syndrome (relative)
- Phaeochromocytoma without prior alpha-blockade — paradoxical hypertensive crisis (never use a beta-blocker before alpha-blocker)
- Severe hepatic impairment (for extensively hepatic-metabolised agents: propranolol, metoprolol, carvedilol, labetalol)
- Severe renal impairment — dose adjustment needed for renal-excreted agents (atenolol, nadolol)
- Hypersensitivity to atenolol
Pregnancy: Category C; cross the placenta; small risk of intrauterine growth restriction, neonatal bradycardia, and hypoglycaemia. Use only if benefit clearly outweighs risk; labetalol is the pregnancy-preferred beta-blocker.
Breastfeeding: small amounts in breast milk; generally considered compatible with monitoring.
Interacțiuni medicamentoase
- Verapamil, diltiazem (non-dihydropyridine CCBs) — additive bradycardia, heart block, and negative inotropy; generally avoid combination. Dihydropyridine CCBs (amlodipine, nifedipine) are safer to combine with beta-blockers.
- Other beta-blockers — do not combine; additive bradycardia
- Clonidine — if stopping clonidine, stop the beta-blocker first (several days before) to avoid rebound hypertensive crisis
- Insulin and sulphonylureas — mask hypoglycaemia warning signs; monitor glucose closely
- AINS — reduce the antihypertensive effect of beta-blockers; avoid chronic combination
- Alcool — additive hypotension and CNS depression (particularly for lipophilic agents)
Beta-Blocker Class at a Glance
| Beta-blocker | Selectivity | Cel mai potrivit pentru |
|---|---|---|
| Propranolol (Inderal, Ciplar, Beloc) | Non-selective | Migraine, tremor, thyrotoxicosis, performance anxiety, HTN |
| Metoprolol | Cardioselective | Post-MI, HF-REF (succinate ER), angina, AF rate control |
| Carvedilol | Non-selective + α-1 | HF-REF (mortality evidence), post-MI |
| Bisoprolol | Highly cardioselective | HF-REF, HTN, angina, AF rate control |
| Nebivolol | Ultra-selective + NO | Elderly, metabolic syndrome, erectile dysfunction |
| Atenolol | Cardioselective (hydrophilic) | Angina, AF rate control (second-line for HTN) |
| Labetalol | Non-selective + α-1 | Pregnancy hypertension, hypertensive crisis |
Renal excretion means dose reduction is needed in renal impairment (halve the dose if eGFR 15-35; every-other-day dosing if eGFR <15). Hydrophilic profile means poor efficacy in migraine and essential tremor — prefer propranolol for those indications.
Depozitare
Store Aten below 25°C. Keep out of reach of children — accidental paediatric beta-blocker ingestion can cause life-threatening bradycardia and hypoglycaemia.
Întrebări frecvente
How long does Aten take to lower blood pressure?
You should see some BP reduction within 1-2 days of starting; the full antihypertensive effect takes 2-4 weeks (driven by the gradual renin-angiotensin suppression, not the immediate heart-rate effect). Measure BP at home at the same time each day to track response.
Can I take Aten if I have asthma?
Atenolol is cardioselective, so it is relatively safer in asthma than non-selective agents. However, cardioselectivity is relative — at higher doses beta-2 blockade can still occur. In severe or brittle asthma, avoid all beta-blockers if possible. In mild asthma or COPD, use with monitoring and inhaler access.
Why should I never stop Aten abruptly?
Abrupt discontinuation causes rebound tachycardia and worsened angina within 24-48 hours, driven by up-regulation of beta receptors during chronic blockade. In patients with coronary artery disease, this can precipitate myocardial infarction or unstable angina. Always taper over 1-2 weeks when stopping.
Will Aten affect my exercise performance?
Yes — beta blockade blunts the heart-rate response to exercise, so your maximum pulse is lower and you fatigue faster at high intensities. For recreational exercise most people adapt; for competitive endurance athletes, beta-blockers can meaningfully impair performance and are banned in precision sports (shooting, archery — where they reduce physiological tremor).
Will Aten affect my blood sugar if I have diabetes?
Beta-blockers mask the tachycardia / tremor / palpitation warning signs of hypoglycaemia, making low blood sugar harder to detect. They can also blunt the counter-regulatory glucose response. Monitor glucose more frequently on a beta-blocker, particularly if on insulin or sulphonylureas. Nebivolol și bisoprolol have the best metabolic profile.
Can I drink alcohol on Aten?
Moderate alcohol is generally acceptable but alcohol potentiates the hypotensive and CNS-depressant effects. Stand up slowly after drinking. Alcohol is also an independent BP-raiser; reducing intake can improve BP control independent of Aten.
Does Aten cause weight gain?
Older beta-blockers (propranolol, atenolol, metoprolol) are associated with modest weight gain (1-3 kg) and worsening of insulin sensitivity over time. Nebivolol and carvedilol are weight-neutral or slightly weight-favourable due to their vasodilator components. For patients with metabolic syndrome, nebivolol is the preferred beta-blocker when one is needed.
Is Aten safe in pregnancy?
Category C. Use only if benefit clearly outweighs risk. For antihypertensive use in pregnancy, labetalol is the preferred beta-blocker; methyldopa and nifedipine are the two other pregnancy-safe options.
Can I take Aten with other BP medications?
Yes — beta-blockers combine well with dihydropyridine calcium-channel blockers (amlodipine), Inhibitori ACE (ramipril, lisinopril), ARBs (losartan, telmisartan, olmesartan), and thiazide diuretics (HCTZ). Avoid combination with non-dihydropyridine CCBs (verapamil, diltiazem) — additive bradycardia and heart-block risk.
Where can I buy Aten online?
You can buy Aten (atenolol 25 / 50 / 100 mg immediate-release tablet, 28-84 tablets) from MedsBase with discreet packaging and worldwide shipping.
Related Beta-Blockers & Antihypertensives
- Carloc — Carvedilol 3.125 mg (HF starter)
- Inderal — Propranolol IR 20/40 mg (AstraZeneca)
- Metomac — Metoprolol 25 mg
- P-Nolol SR — Propranolol 80 mg sustained-release
- Provanol — Propranolol 10 mg
- Provanol SR — Propranolol 80 mg SR
- Browse all High Blood Pressure Medications
Mai multe opțiuni în medicamente pentru hipertensiune arterială
Clasificate în funcție de volumul recent de comenzi MedsBase — ce aleg alți clienți în această categorie.
| Concentrație | 25 mg, 50 mg, 100 mg |
|---|---|
| Cantitate | 28 Tablet/s, 56 Tablet/s, 84 Tablet/s |
| Formă farmaceutică | Comprimat/e |
| Producător | Zydus Cadila Pharma |
| Indicație | High blood pressure, Chest pain (Angina), Heart failure |
| Brand generic | Atenolol |
Aten
Întrebări și răspunsuri
Aten
Produse similare
Recenzii
Nu există recenzii încă