Doxolin
✅ Asthma symptom management
✅ Convenient tablet format
✅ Easy administration
✅ Enhanced respiratory comfort
Contains Doxofylline
✓ Verificat medical de Morgan Ellis — Cercetător farmaceutic · 8 ani de experiență · Ultima recenzie: mai 2026
⚡ Quick Answer — What is Doxolin?
Doxolin conține doxofylline, un methylxanthine bronchodilator with anti-inflammatory effects, used as add-on therapy for chronic asthma and COPD. Doxofylline is a newer methylxanthine with similar efficacy to theophylline but a wider safety margin — fewer cardiac, GI, and CNS side effects. No routine drug-level monitoring required. Dose is 400 mg once or twice daily. Each tablet contains 400 mg, fabricată de Zydus Cadila at WHO-GMP certified facilities.
📦 Fiecare comandă este acoperită de politica noastră de Politica noastră de Reexpediere Garantată — dacă coletul dumneavoastră nu sosește în 20 de zile lucrătoare, îl relivrăm.
De ce să comanzi de la MedsBase
Medicamentele noastre generice sunt procurate de la producători certificați WHO-GMP și expediate la nivel mondial în ambalaje discrete și simple — fără denumirea medicamentului pe exteriorul coletului. Plățile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de plăți cu card reglementat — niciodată “MedsBase” sau numele vreunui medicament). Acceptăm și criptomonede și transferuri bancare SEPA. Fiecare comandă este susținută de Politica noastră de Asigurare pentru Relivrare.
What Is Doxolin?
Doxolin is an oral methylxanthine bronchodilator. Methylxanthines are derived from natural alkaloids (theophylline is the dimethylxanthine present in tea). Their use has declined since the 1990s as inhaled β2-agonists and corticosteroids became first-line — but they retain a role as third-line add-on therapy in difficult asthma and COPD.
How Does Doxolin Work?
- Phosphodiesterase inhibition (PDE3, PDE4) — raises cyclic AMP in airway smooth muscle and inflammatory cells; net result is bronchodilation and reduced mediator release.
- Adenosine receptor antagonism — blocks adenosine-mediated bronchoconstriction and mast-cell mediator release.
- HDAC2 activation (theophylline at low serum levels 5–10 mg/L) — restores corticosteroid responsiveness in COPD and severe asthma where steroid resistance is partly mediated by reduced HDAC2.
- Diaphragm contractility — methylxanthines reduce diaphragm fatigue, useful in COPD with severe airflow limitation.
Utilizări și indicații
- Severe chronic asthma — add-on to high-dose ICS-LABA where additional bronchodilation is needed
- COPD maintenance — add-on to LAMA-LABA or triple therapy
- Nocturnal asthma — sustained-release formulation provides overnight bronchodilation
- Apnoea of prematurity (theophylline) — neonatal use
- Theophylline-intolerant patients — better-tolerated alternative
Doxolin Dosage
| Patient | Doza | Frecvență |
|---|---|---|
| Adults — initial | 200 mg | Three times daily — first 7 days |
| Adults — maintenance | 400 mg | Once or twice daily |
| Elderly / liver disease | Halve dose | Once or twice daily |
Side Effects of Doxolin
- Nausea, vomiting, dyspepsia
- Dureri de cap
- Tremor
- Insomnia, restlessness
- Mild palpitations (less than theophylline)
- Mild hypokalaemia at high doses
Serious — stop and seek help:
- Severe palpitations or arrhythmia
- Persistent vomiting
- Reacție alergică severă
Avertismente și precauții
- No routine blood-level monitoring — wider safety margin than theophylline.
- Many drug interactions — see interactions table. Most metabolised by CYP1A2; many inhibitors and inducers shift levels significantly.
- Smoking induces CYP1A2 and lowers theophylline levels by ~50% — re-titrate at smoking cessation.
- Cardiac disease: use cautiously in arrhythmias, heart failure, severe hypertension.
- Hyperthyroidism: increased clearance plus exaggerated adrenergic effects.
- Sarcină și alăptare: generally avoided; use only if benefit clear.
- Liver disease: reduce dose — methylxanthines are hepatically metabolised.
Contraindicații
- Hypersensitivity to doxofylline or other xanthines (caffeine, theobromine)
- Active peptic ulcer disease
- Uncontrolled tachyarrhythmias
- Severe heart failure (NYHA IV)
Interacțiuni medicamentoase
| Interacting drug | Efect | Ce să faceți |
|---|---|---|
| Ciprofloxacin, erythromycin, clarithromycin, fluvoxamine | Inhibit CYP1A2 → raise theophylline levels → toxicity (nausea, arrhythmia, seizures) | Avoid or reduce theophylline dose 50%; check serum levels |
| Cimetidine, allopurinol | Raise theophylline levels | Reduce dose; monitor levels |
| Phenytoin, carbamazepine, rifampicin | Induce CYP — lower levels | Higher dose may be needed |
| Smoking | Induces CYP1A2 — lower levels | Re-titrate dose at smoking cessation |
| β-agonists, diuretics | Additive hypokalaemia | Monitor potassium |
Depozitare
- Store below 25°C in a cool, dry place away from direct sunlight.
- Keep in original packaging until use to protect from moisture and light.
- Do not use after the expiry date printed on the strip.
- Keep out of reach of children.
Alternative conexe pe MedsBase
- Asthalin Inhaler — salbutamol reliever
- Budecort Inhaler — budesonide ICS preventer
- Foracort Inhaler — budesonide + formoterol ICS-LABA
- Tiova Inhaler — tiotropium LAMA for COPD
- Montair — montelukast LTRA tablet
Întrebări frecvente
How is doxofylline different from theophylline?
Doxofylline is a newer methylxanthine (introduced in the 1990s) with similar bronchodilator efficacy and a wider safety margin. Cardiac, GI, and CNS side effects are less common; routine blood-level monitoring is not required; and it has fewer drug interactions.
Why prefer doxofylline over theophylline?
Better tolerability, simpler dosing (no level monitoring), fewer interactions. Particularly useful in elderly patients and those who could not tolerate theophylline.
How fast does Doxolin work?
Bronchodilation begins within 1 hour; full effect over days.
Is Doxolin a reliever?
No — it is a controller. Keep a SABA (Asthalin, Levolin) for acute attacks.
Can I take Doxolin with my ICS?
Yes — doxofylline is typically added on top of ICS or ICS-LABA when additional bronchodilation is needed.
What are the common side effects?
Nausea, mild headache, tremor, insomnia. Generally milder than theophylline at equivalent bronchodilation.
Is Doxolin safe in pregnancy?
Limited data; inhaled therapy is preferred.
Can children take Doxolin?
Use with caution; specialist supervision recommended in paediatric use.
How does Doxolin compare to roflumilast (Rofaday)?
Both are oral non-bronchodilator-class agents with anti-inflammatory effects. Roflumilast is specifically for severe COPD with chronic bronchitis. Doxofylline has broader use across asthma and COPD as an add-on bronchodilator.
Alternative conexe
Alte produse din Afecțiuni cronice pe care clienții le vizualizează de asemenea:
More options in Asthma/COPD Treatment
Clasificate în funcție de volumul recent de comenzi MedsBase — ce aleg alți clienți în această categorie.
| Concentrație | 400 mg |
|---|---|
| Cantitate | 30 Tablet/s, 60 Tablet/s, 90 Tablet/s |
| Formă farmaceutică | Comprimat/e |
| Producător | Zydus Cadila Pharma |
| Indicație | Asthma prevention, Chronic obstructive pulmonary disease (COPD) |
| Brand generic | Levosalbutamol + Ipratropium |
Doxolin
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