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Montek Plus

✅ Manages asthma
✅ Controls wheezing
✅ Reduces bronchoconstriction
✅ Eases breathing
✅ Prevents airway inflammation

Montek Plus contains Montelukast & Bambuterol.

Verificat medical de Morgan Ellis — Cercetător farmaceutic · 8 ani de experiență  · Ultima recenzie: mai 2026

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⚡ Quick Answer — What is Montek Plus?

Montek Plus conține montelukast + levocetirizine, an oral preventer for asthma and allergic rhinitis. The combination delivers montelukast (a leukotriene receptor antagonist that blocks LTD4 mediator action) plus levocetirizine (a non-sedating second-generation H1 antihistamine). Used for allergy-driven asthma where rhinitis and bronchospasm coexist (the United Airways disease). Each tablet contains montelukast 10 mg + levocetirizine 5 mg, fabricată de Sun Pharma. Taken once daily in the evening.

Important — neuropsychiatric warning: the FDA added a black-box warning in 2020 noting reports of mood changes, sleep disturbance, anxiety, depression, and (rarely) suicidal ideation with montelukast. Discuss any new mood symptoms with your prescriber.

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What Is Montek Plus?

Montek Plus is a combination of montelukast (LTRA) and levocetirizine (antihistamine) manufactured by Sun Pharma at WHO-GMP certified facilities. Available as 4 mg, 5 mg, and 10 mg tablets — strengths chosen by age and indication.

How Does Montek Plus Work?

  • Montelukast selectively antagonises the CysLT1 receptor — preventing LTD4-mediated bronchoconstriction, eosinophil recruitment, mucus hypersecretion, and microvascular leak.
  • Levocetirizine (active R-isomer of cetirizine) blocks histamine H1 receptors with high selectivity — controls itching, sneezing, runny nose, and mild bronchospasm without significant sedation.
  • Combined the two molecules cover the leukotriene and histamine arms of the allergy cascade, giving more complete control of allergic asthma and rhinitis than either alone.

Utilizări și indicații

  • Persistent asthma — add-on preventer in patients not controlled by ICS alone (alternative to LABA or LAMA add-on)
  • Exercise-induced asthma — particularly effective; taken 2 hours before exercise
  • Aspirin-exacerbated respiratory disease (AERD) — leukotrienes are central to this phenotype
  • Allergic rhinitis — both seasonal (hay fever) and perennial
  • Allergic asthma with concomitant rhinitis — the combo addresses both compartments simultaneously
  • Chronic urticaria — montelukast as adjunct to high-dose antihistamine

Montek Plus Dosage

PatientDozaFrecvență
Adults & children >15 yr1 tabletăOnce daily in the evening
Children 6–14 yr (Montek Plus 5 strength)1 tablet (5 mg + 2.5 mg)Once daily in the evening

Side Effects of Montek Plus

  • Dureri de cap
  • Mild abdominal pain or nausea
  • Sleep disturbance (vivid dreams, insomnia)
  • Mood changes — irritability, anxiety, depression (FDA black-box warning, 2020)
  • Mild drowsiness from levocetirizine in some users (less than first-generation antihistamines)
  • Rash

Serious — stop and seek help:

  • Severe allergic reaction / angio-oedema
  • Suicidal ideation or severe depression — STOP and seek urgent psychiatric review
  • Churg-Strauss syndrome (eosinophilic vasculitis) — rare; suspect in ICS-tapering patients with new vasculitic features (rash, neuropathy, eosinophilia)
  • Hepatitis (rare)

Avertismente și precauții

  • Black-box warning — neuropsychiatric events. If new mood changes, anxiety, sleep disturbance, agitation, depression, or suicidal thoughts occur, stop Montek Plus and contact your prescriber.
  • Not a rescue medication. Do not use in acute asthma attacks — onset is too slow.
  • Continue ICS if previously prescribed; montelukast does not replace inhaled corticosteroids.
  • Hepatic impairment: use cautiously in moderate-to-severe disease.
  • Sarcină și alăptare: reasonable safety data; use when benefits outweigh risks.
  • Children may show increased risk of behavioural changes — counsel parents to monitor mood.

Contraindications

  • Hypersensitivity to montelukast, levocetirizine, or excipients
  • Severe hepatic impairment — relative
  • Severe renal impairment — levocetirizine accumulates

Interacțiuni medicamentoase

Interacting drugEfectCe să faceți
Phenobarbital, phenytoin, rifampicinInduce CYP enzymes — reduce montelukast levelsMonitor asthma control
GemfibrozilInhibits CYP2C8 — increases montelukast levelsUse with caution
WarfarinTheoretical INR change reported in case reportsMonitor INR after starting/stopping

Depozitare

  • Store below 25°C in a cool, dry place away from direct sunlight.
  • Keep in original packaging until use to protect from moisture and light.
  • Do not use after the expiry date printed on the strip.
  • Keep out of reach of children.

Alternative conexe pe MedsBase

Întrebări frecvente

When should I take montelukast?

Once daily in the evening, with or without food. Evening dosing matches the typical overnight rise in leukotriene mediators and gives best protection against early-morning symptoms.

How long until montelukast works?

Some symptom relief within 24–48 hours. Full effect on asthma exacerbation rate develops over 4–8 weeks.

Should I worry about the FDA black-box warning?

The 2020 FDA black-box warning highlighted reports of mood changes, sleep disturbance, anxiety, depression, and rarely suicidal ideation — particularly in children. The absolute risk is low but real. Watch for any new mood symptoms in yourself or your child; stop the drug and contact your prescriber if they appear.

Can montelukast replace my inhaler?

No — montelukast is an add-on preventer. It does not replace inhaled corticosteroids (Budecort, Beclate, Foracort, Seretide). Continue ICS as prescribed.

Is montelukast a rescue medication?

No — onset is too slow. Use a SABA (Asthalin, Levolin) for acute attacks.

Can children take montelukast?

Yes from 6 months of age in age-appropriate strengths (4 mg granules, 4 mg or 5 mg chewable, 10 mg tablet). Counsel parents to monitor mood and behaviour.

Is montelukast safe in pregnancy?

Reasonable observational data; use when benefits outweigh risks, particularly in patients whose asthma is well-controlled on it.

Does montelukast help allergic rhinitis?

Yes — montelukast is licensed for both asthma and allergic rhinitis. Particularly useful when both coexist (United Airways disease).

Should I stop montelukast if I feel better?

No — continue daily for as long as your prescriber advises. Stopping leads to gradual return of symptoms over days-to-weeks.

When is the Montek Plus combination used?

When asthma and allergic rhinitis coexist (the United Airways disease). The fixed-dose combination simplifies the regimen — one tablet covers both leukotriene and histamine arms of the allergy cascade.

Will Montek Plus make me drowsy?

Levocetirizine is a non-sedating second-generation antihistamine — drowsiness is uncommon (about 5–7% in trials, less than cetirizine). The drowsiness, if any, is usually mild.

Medical disclaimer: This page is educational and does not replace professional medical advice. Always consult a qualified healthcare professional before starting, stopping, or changing any inhaler or respiratory medication, especially if you have other medical conditions, take other prescriptions, are pregnant or breastfeeding, or are over 65.

Alternative conexe

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Concentrație

10+10 mg

Cantitate

30 Comprimat/e, 60 Comprimat/e, 90 Comprimat/e, 180 Comprimat/e

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