Dorzox T Eye Drop
Dorzox T (dorzolamide 2% + timolol 0.5%) — fixed-combination CAI + beta-blocker eye drop. Twice-daily IOP control for open-angle glaucoma. Sulfa cross-reactivity caution.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
⚡ Quick Answer — What is Dorzox T Eye Drop?
Dorzox T Eye Drop combines dorzolamide 2% (carbonic anhydrase inhibitor) with timolol 0.5% (beta-blocker) in one bottle for advanced glaucoma. Twice-daily dosing. Avoid in asthma, severe COPD, bradycardia, AV block, and severe sulfonamide allergy.
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What is Dorzox T Eye Drop?
Dorzox T Eye Drop is a fixed-dose combination eye drop manufactured by Cipla, containing dorzolamide HCl 2% (CAI) and timolol maleate 0.5% (non-selective beta-blocker) in a 5 mL bottle. Both components reduce aqueous humour production through different mechanisms, giving moderately additive ~25–30% IOP reduction in twice-daily dosing.
How It Works
Dorzolamide blocks carbonic anhydrase II in the ciliary epithelium, reducing bicarbonate-driven aqueous secretion. Timolol blocks beta-adrenergic receptors at the same site, reducing cAMP-driven aqueous secretion. The combination is more potent than either monotherapy and equivalent to giving the two drugs separately, with the convenience of a single bottle.
Indications & Dosing
One drop in affected eye(s) twice daily (morning and evening). Wait 5 minutes between other eye drops. Practise punctal occlusion for 1–2 minutes after each drop to reduce systemic timolol absorption. Remove contact lenses before instillation; reinsert after 15 minutes.
Side Effects
Local: stinging, bitter taste, blurred vision, conjunctival hyperaemia, ocular pruritus, dry eye, eyelid dermatitis.
Systemic (mostly from timolol): bradycardia, hypotension, fatigue, depression, bronchospasm in reactive airways, masking of hypoglycaemia signs, decreased libido.
Warnings & Contraindications
- Asthma, severe COPD — absolute contraindications
- Sinus bradycardia, second/third-degree AV block, decompensated heart failure
- Severe sulfonamide hypersensitivity
- Severe renal impairment (CrCl < 30)
- Concurrent oral beta-blockers, calcium-channel blockers, or digoxin — additive bradycardia
- Pregnancy Category C — avoid
- Corneal endothelial dysfunction
Storage
Store at 15–25°C protected from light. Discard 28 days after first opening.
Frequently Asked Questions
When should I use Dorzox T Eye Drop?
Twice daily, morning and evening, ideally 12 hours apart.
Why a fixed combination?
Adherence improves significantly with one bottle vs two. Both ingredients work on aqueous production from different angles, so the combination is moderately additive (about 1.5× either alone).
Can I use Dorzox T Eye Drop with asthma?
No — the timolol component can trigger bronchospasm even when applied to the eye. Switch to a non-beta-blocker combination or a brinzolamide+brimonidine approach.
What is punctal occlusion?
Pressing the inner corner of your eye for 1–2 minutes after instillation. This blocks the nasolacrimal duct and reduces systemic absorption by ~70%, lowering bradycardia and bronchospasm risk.
Can I drive after instilling Dorzox T Eye Drop?
There is transient blur for 5–10 minutes. Wait until vision clears.
What about kidney stones?
Topical CAIs deliver minimal systemic exposure compared with oral acetazolamide, so kidney-stone risk is very low. If you have a personal or family history of calcium-oxalate stones, mention it to your prescriber.
Will I taste the drop?
A bitter taste is common because of nasolacrimal drainage into the throat. Punctal occlusion minimises this.
What if I have a sulfa allergy?
Severe reactions (Stevens-Johnson, anaphylaxis) to sulfonamides are an absolute contraindication. Mild rash to sulfamethoxazole alone is not — discuss with your prescriber.
Is Dorzox T Eye Drop safe in pregnancy?
Category C. Avoid unless your ophthalmologist determines the benefit outweighs risk. Brimonidine or PGA monotherapy is preferred during pregnancy.
What if I miss a dose?
Take it as soon as you remember unless the next dose is close. Never double up.
Other Eye-Care Medications
Customers viewing this product also consider these alternatives in our Eye Care range:
- Xalatan Eye Drop (latanoprost)
- Azopt Eye Drops (brinzolamide)
- Alphagan P Drop (brimonidine)
- Iotim Eye Drops (timolol)
- Careprost (bimatoprost)
Medical Disclaimer
The information on this page is for educational purposes only and is not a substitute for medical advice from a qualified ophthalmologist or optometrist. Eye conditions can rapidly threaten sight — sudden vision loss, severe pain, or trauma is an ophthalmology emergency. Always consult an eye-care professional before starting, stopping, or changing any treatment.
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| Strength | 5 ml Eye Drop |
|---|---|
| Quantity | 1 Bottle/s, 3 Bottle/s, 6 Bottle/s |
| Pharma Form | Eye Drop/s |
| Manufacturer | Cipla Inc |
| Treatment | Eye Care |
| Generic Brand | Dorzolamide + Timolol |
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