Topgraf Ointment
✅ Reduces skin inflammation
✅ Treats eczema symptoms
✅ Alleviates psoriasis discomfort
✅ Manages dermatitis conditions
✅ Promotes skin healing
✓ Verificat medical de Morgan Ellis — Cercetător farmaceutic · 8 ani de experiență · Ultima recenzie: mai 2026
💡 Quick Answer — What is Topgraf Ointment?
Topgraf Ointment contains tacrolimus 0.03% or 0.1% — a topical calcineurin inhibitor (steroid-sparing immunomodulator) for moderate-to-severe atopic dermatitis (eczema), particularly on face, eyelids, and flexures. Apply a thin film twice daily on affected skin until clear, then twice weekly as maintenance. Standard adult strength is 0.1%; paediatric strength is 0.03%. Initial burning/stinging is common during the first week and usually resolves with continued use. SPF 30+ daily during therapy.
📦 Fiecare comandă este acoperită de politica noastră de Politica noastră de Reexpediere Garantată — dacă coletul dumneavoastră nu sosește în 20 de zile lucrătoare, îl relivrăm.
De ce să comanzi de la MedsBase
Medicamentele noastre generice sunt procurate de la producători certificați WHO-GMP și expediate la nivel mondial în ambalaje discrete și simple — fără denumirea medicamentului pe exteriorul coletului. Plățile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de plăți cu card reglementat — niciodată “MedsBase” sau numele vreunui medicament). Acceptăm și criptomonede și transferuri bancare SEPA. Fiecare comandă este susținută de Politica noastră de Asigurare pentru Relivrare.
De ce să comanzi de la MedsBase
Choosing Topgraf Ointment from MedsBase:
- producător certificat WHO-GMP — sourced from a regulated facility, finished pack with batch number and expiry.
- Ambalaj discret — plain envelope, no medication name on the outside.
- Livrare în toată lumea cu Reshipment Assurance — if your parcel does not arrive within 20 business days we re-ship at no cost (subject to policy terms).
- Loyalty points — 1 point per $1 spent (excludes peptides); 100 points = $5 off.
What Topgraf Ointment is and how it works
Topgraf Ointment contains tacrolimus 0.03% or 0.1%. Tacrolimus is a macrolide calcineurin inhibitor — it binds FK-binding protein-12 (FKBP-12); the resulting complex inhibits calcineurin phosphatase, blocking dephosphorylation of NFAT and preventing transcription of T-cell activation cytokines (IL-2, IL-4, IFN-γ). The net effect is targeted suppression of skin inflammation without the skin-thinning, atrophy, or HPA-axis effects of topical corticosteroids. Manufacturer: Glenmark / generics (WHO-GMP certified).
Indicații
- Moderate-to-severe atopic dermatitis (eczema) — second-line where topical steroids are unsafe or inadequate.
- Eyelid and facial eczema — first-line steroid-sparing option (steroids on eyelids cause cataracts and glaucoma).
- Vitiligo — off-label, often combined with phototherapy, for facial and intertriginous patches.
- Steroid-induced rosacea / perioral dermatitis — steroid-sparing taper.
- Lichen planus — including oral and vulvovaginal forms.
- Lichen sclerosus — second-line after potent steroid induction.
Cum să aplicați
- Wash hands. Apply a thin layer to affected skin only, twice daily.
- Continue until clear, then maintenance: twice-weekly application on previously affected sites for relapse prevention.
- Adults: 0.1%. Children 2–15: 0.03%.
- Avoid occlusive dressings unless directed.
- Use SPF 30+ broad-spectrum daily during therapy — tacrolimus increases UV sensitivity.
⚠️ FDA black-box warning — Tacrolimus carries an FDA black-box warning regarding a theoretical lymphoma and skin cancer risk based on rodent studies and rare post-marketing case reports. Long-term human cohort studies have not confirmed an increased risk. Use the lowest effective frequency for the shortest duration; avoid in immunocompromised patients; ensure daily sun protection; report any new persistent skin lesion.
Efecte secundare
- Very common (first 1–2 weeks): burning, stinging, warmth at the application site — usually settles with continued use.
- Frecvente: mild itching, erythema, headache, alcohol intolerance (facial flushing with even small amounts of alcohol).
- Mai puțin frecvente: folliculitis, herpes simplex flare-up.
- Rare: photosensitivity, contact allergy.
Contraindicații
- Children under 2 years.
- Active bacterial, viral, or fungal skin infection without concurrent treatment.
- Netherton syndrome and other genetic skin-barrier disorders (excessive systemic absorption).
- Immunosuppression (HIV, transplant, chemotherapy).
- Known hypersensitivity to tacrolimus.
Interacțiuni medicamentoase
Topical absorption is low, but avoid concurrent topical erythromycin and other macrolide antibiotics on the same skin (additive effect). Caution with strong CYP3A4 inhibitors (clarithromycin, itraconazole, ritonavir) — although systemic levels are usually trivial, large-area or barrier-impaired application can raise systemic tacrolimus enough to matter.
Depozitare
Store below 25 °C in the original tube. Keep tube tightly closed. Do not refrigerate.
Întrebări frecvente
Why does Topgraf Ointment burn when first applied?
Initial burning/stinging at the application site is the most common side effect, occurring in ~50% of users during the first week. It is thought to be due to substance-P release in cutaneous nerve fibres. It typically settles within 7 days of continued use. Cooling the cream in the fridge before application can help.
Is tacrolimus safer than topical steroids for long-term use?
Yes — tacrolimus does not cause skin atrophy, telangiectasia, or HPA-axis suppression even with prolonged use, making it preferable for long-term maintenance and for thin-skinned areas (face, eyelids, flexures). The trade-off is the upfront burning sensation and the FDA black-box on theoretical malignancy risk.
Can I use Topgraf Ointment on my face?
Yes — face, eyelids, and flexures are exactly where topical tacrolimus is most useful, since potent steroids on these areas cause atrophy, rosacea, perioral dermatitis, cataracts, and glaucoma. Tacrolimus is preferred for facial eczema in adults and children.
Why must I use sunscreen with tacrolimus?
Tacrolimus increases UV sensitivity. The FDA recommends daily broad-spectrum SPF 30+ sunscreen during therapy and limiting tanning beds and prolonged sun exposure.
Is the lymphoma warning real?
The rodent studies showed lymphoma at very high systemic doses (~30–50× human topical exposure). Long-term cohort studies in humans (>20 years post-launch) have NOT confirmed an increased lymphoma rate. The black-box is a precautionary FDA classification rather than evidence of meaningful risk in normal use.
Can I drink alcohol while using Topgraf Ointment?
Some users develop facial flushing within 5 minutes of alcohol consumption — this is a recognised side effect and resolves on stopping the drug. It does not indicate liver toxicity.
How long can I use Topgraf Ointment for?
Indefinitely if needed. Maintenance use (twice-weekly) for atopic dermatitis is well-established for relapse prevention. Re-evaluate every 6 months and step down where possible.
Can I use it during pregnancy?
Limited data; tacrolimus crosses the placenta. Topical absorption is minimal so risk is low, but use only if benefit clearly outweighs risk and discuss with your specialist.
What should I use it with — moisturiser before or after?
Moisturise after waiting 15–30 minutes from tacrolimus application. Heavy occlusive moisturisers immediately after the drug can amplify absorption.
Is Topgraf Ointment the same as Protopic?
Yes — Protopic is the original brand of tacrolimus ointment from Astellas. Topgraf Ointment is a generic equivalent containing the same active ingredient at the same strengths.
Other Beauty & Skin Care Medications
- Melalite Forte Cream — hydroquinone 4% for melasma
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- Melacare Cream — Kligman triple for melasma
- Permite Cream — permethrin 5% for scabies
- Tenovate Cream — clobetasol 0.05% for severe inflammation
Notă medicală. This content is for general information about the product and is not medical advice or a substitute for advice from a qualified healthcare professional. Use any topical or oral medication only under appropriate medical supervision; misuse can cause serious harm.
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Clasificate în funcție de volumul recent de comenzi MedsBase — ce aleg alți clienți în această categorie.
| Concentrație | 0.03%, 0.10% |
|---|---|
| Cantitate | 1 Tube/s, 3 Tube/s, 6 Tube/s |
| Formă farmaceutică | Ointment |
| Producător | Glaxo SmithKline |
| Indicație | Atopic dermatitis |
| Brand generic | Tacrolimus |
Topgraf Ointment
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