Udimax 300
Udimax 300 (Ursodeoxycholic Acid 300 mg) — hydrophilic bile acid for primary biliary cholangitis, cholesterol gallstones, intrahepatic cholestasis of pregnancy, and bile-acid diarrhoea. WHO Essential Medicine for PBC. Worldwide shipping from MedsBase.
✓ Verificat medical de Morgan Ellis — Cercetător farmaceutic · 8 ani de experiență · Ultima recenzie: mai 2026
⚡ Quick Answer — What is Udimax 300?
Udimax 300 este ursodeoxycholic acid (UDCA) 300 mg — a hydrophilic bile acid that is the standard of care for primary biliary cholangitis (PBC), cholesterol gallstones in patients unfit for surgery, intrahepatic cholestasis of pregnancy (ICP), bile-acid diarrhoea, and pruritus of cholestatic liver disease. UDCA reduces cholesterol saturation in bile, replaces toxic hydrophobic bile acids in the bile-acid pool, exerts cytoprotective and anti-apoptotic effects on hepatocytes and cholangiocytes, and stimulates bicarbonate-rich choleresis. Standard adult doses range from 10–15 mg/kg/day for PBC and gallstones to 14–30 mg/kg/day for cholestasis of pregnancy. WHO-GMP certified manufacturer.
📦 Fiecare comandă este acoperită de politica noastră de Politica noastră de Reexpediere Garantată — dacă coletul dumneavoastră nu sosește în 20 de zile lucrătoare, îl relivrăm.
De ce să comanzi de la MedsBase
Medicamentele noastre generice sunt procurate de la producători certificați WHO-GMP și expediate la nivel mondial în ambalaje discrete și simple — fără denumirea medicamentului pe exteriorul coletului. Plățile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de plăți cu card reglementat — niciodată “MedsBase” sau numele vreunui medicament). Acceptăm și criptomonede și transferuri bancare SEPA. Fiecare comandă este susținută de Politica noastră de Asigurare pentru Relivrare.
De ce să comanzi de la MedsBase
Udimax 300 is supplied from a producător certificat WHO-GMP. Every order ships discreetly worldwide and is covered by our Politica noastră de Reexpediere Garantată — if it does not arrive within 20 business days, we reship at no cost. UDCA has been on the WHO Essential Medicines List for decades and is the cornerstone of medical therapy for cholestatic liver disease.
Mechanism
UDCA is a naturally occurring hydrophilic 7β-hydroxy bile acid (“the bear bile acid”). When taken orally it enriches the bile-acid pool, replacing toxic hydrophobic acids (chenodeoxycholic, lithocholic) that damage cholangiocytes and hepatocytes in cholestasis. Three actions matter clinically: (1) it reduces biliary cholesterol saturation, dissolving cholesterol gallstones over months; (2) it exerts direct cytoprotective and anti-apoptotic effects on liver cells, reducing immune-mediated damage in PBC; (3) it stimulates a bicarbonate-rich “alkaline tide” choleresis, which protects cholangiocytes from the detergent action of hydrophobic bile acids. Onset of biochemical improvement in PBC is typically 2–6 months.
Indications & doses
| Indicație | Doza | Note |
|---|---|---|
| Primary biliary cholangitis (PBC) | 13–15 mg/kg/day in 1–2 divided doses | Pe viață |
| Cholesterol gallstones (radiolucent, non-calcified, < 15 mm, functioning gallbladder) | 8–10 mg/kg/day | 6–24 months; recurrence common after stopping |
| Intrahepatic cholestasis of pregnancy | 10–15 mg/kg/day, may rise to 25 mg/kg/day | Reduces pruritus, normalises bile acids; PITCHES trial showed mixed effect on stillbirth |
| Bile-acid diarrhoea | 250–500 mg twice daily (off-label) | Combine with bile-acid binders (cholestyramine) |
| PSC, cystic fibrosis liver disease, paediatric biliary atresia | 20–30 mg/kg/day | Specialist supervision; high-dose in PSC limited to 20 mg/kg/day after a 30 mg/kg trial showed harm |
Efecte secundare
- Common: diarrhoea (dose-related), abdominal cramps, nausea
- Skin reactions (rash, pruritus — transient, opposite to its therapeutic effect on cholestatic itch)
- Calcified gallstones (rare; on long courses)
- Worsening ascites in advanced cirrhosis (rare)
Interacțiuni medicamentoase
- Cholestyramine, colestipol, antacids (aluminium): bind UDCA and reduce absorption — separate by 2 hours.
- Combined OC pill, oestrogens, clofibrate: increase biliary cholesterol saturation and oppose the gallstone-dissolution effect.
- Ciclosporin: UDCA may improve ciclosporin absorption; monitor levels.
- Nitrendipine, dapsone: levels may fall on UDCA — monitor.
Întrebări frecvente
How long until I see improvement?
In PBC, ALP and ALT begin to fall within 4–8 weeks; full biochemical response is judged at 12 months. Pruritus often improves within weeks. Gallstone dissolution takes 6–24 months and only works for cholesterol stones.
Will it dissolve all gallstones?
No. Only radiolucent, non-calcified, cholesterol stones < 15 mm in a functioning gallbladder will dissolve. Pigment stones, calcified stones, and cholecystitis will not respond. Recurrence after stopping is common (~50 percent in 5 years) so cholecystectomy remains preferred when feasible.
Is it safe in pregnancy?
Yes. UDCA is the recognised therapy for intrahepatic cholestasis of pregnancy (ICP), reducing maternal pruritus and bile-acid levels. Discuss with obstetric prescriber.
Can I drink alcohol on it?
Avoid heavy alcohol — it worsens any underlying liver disease. Light intake is acceptable in PBC at the prescriber’s discretion.
Why do I have diarrhoea?
Excess UDCA reaches the colon and acts as an osmotic / secretory laxative. Splitting the dose (e.g. 300 mg morning and evening rather than 600 mg once) usually helps. If persistent, dose reduction is reasonable in stone-dissolution use; in PBC, prioritise the dose for biochemical response.
Will I need it for life?
In PBC: yes. In gallstones: only until they dissolve (then stop, accept recurrence risk). In ICP: until delivery and normalisation of bile acids.
Should I take it with food?
Take with meals. Bile-acid recycling during the postprandial period maximises enterohepatic circulation and the therapeutic effect.
Can I take it with cholestyramine?
Yes, but separate by 2 hours — cholestyramine binds bile acids and would inactivate the dose if taken simultaneously.
Depozitare
Below 25°C, dry place. Keep tablets in the original blister.
Ce fac dacă uit o doză?
Take it as soon as you remember. If close to the next dose, skip it. Do not double up.
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Clasificate în funcție de volumul recent de comenzi MedsBase — ce aleg alți clienți în această categorie.
| Concentrație | 300 mg |
|---|---|
| Cantitate | 30 Comprimat/e, 60 Comprimat/e, 90 Comprimat/e, 180 Comprimat/e |
Udimax 300
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