Seroflo Multihaler
✅ Long-term asthma control
✅ Reduces airway inflammation
✅ Relieves bronchospasm
✅ Improves lung function
✅ Prevents asthma symptoms
Seroflo Multihaler contains Salmeterol and Fluticasone Propionate.
✓ Verificat medical de Morgan Ellis — Cercetător farmaceutic · 8 ani de experiență · Ultima recenzie: mai 2026
⚡ Quick Answer — What is Seroflo Multihaler?
Seroflo Multihaler este un combination preventer (controller) inhaler for asthma and COPD, containing fluticasone propionate (an inhaled corticosteroid that reduces airway inflammation) plus salmeterol (a long-acting β2 agonist that holds the airways open for 12 hours). Each dose delivers fluticasone 100/250 mcg + salmeterol 50 mcg per dose, fabricată de Cipla at WHO-GMP certified facilities — the same active drugs as international brand Seretide Multidose. Seroflo Multihaler is taken twice daily, every day, even when symptoms are absent. It is a preventer, not a rescue inhaler — keep a SABA reliever (Asthalin, Levolin) for acute attacks. Rinse mouth and gargle after every dose to prevent oral thrush and hoarseness.
📦 Fiecare comandă este acoperită de politica noastră de Politica noastră de Reexpediere Garantată — dacă coletul dumneavoastră nu sosește în 20 de zile lucrătoare, îl relivrăm.
De ce să comanzi de la MedsBase
Medicamentele noastre generice sunt procurate de la producători certificați WHO-GMP și expediate la nivel mondial în ambalaje discrete și simple — fără denumirea medicamentului pe exteriorul coletului. Plățile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de plăți cu card reglementat — niciodată “MedsBase” sau numele vreunui medicament). Acceptăm și criptomonede și transferuri bancare SEPA. Fiecare comandă este susținută de Politica noastră de Asigurare pentru Relivrare.
What Is Seroflo Multihaler?
Seroflo Multihaler is an Indian-manufactured dry-powder multihaler combinând fluticasone propionate + salmeterol. The international brand of this combination is Seretide Multidose. Combination ICS-LABA inhalers deliver superior asthma and COPD control compared to either component alone, with a single device improving adherence and reducing the risk of using LABA monotherapy (which carries a black-box warning for asthma death without concomitant ICS).
How Does Seroflo Multihaler Work?
The two active ingredients work on different mechanisms in parallel:
- fluticasone propionate (inhaled corticosteroid): suppresses inflammatory cytokines, reduces eosinophil and lymphocyte infiltration, stabilises airway mucosa, restores β2 receptor responsiveness. Effect builds over 1–2 weeks of consistent dosing.
- salmeterol (long-acting β2 agonist): activates bronchial smooth muscle β2 receptors, raising cyclic AMP and producing sustained bronchodilation lasting 12 hours (formoterol has 1–3 minute onset; salmeterol 15–30 minute onset).
- Synergy: the corticosteroid restores β2 receptor expression and prevents tachyphylaxis to LABA; the LABA improves smooth-muscle relaxation that ICS alone does not address. Combined, they reduce exacerbations more than either component alone at equivalent doses.
Utilizări și indicații
- Persistent asthma not controlled by ICS alone — first-line ICS-LABA combination
- Asthma maintenance therapy — twice daily, every day, regardless of symptoms
- COPD with frequent exacerbations, especially with elevated blood eosinophil count (≥300/µL) or asthma overlap
- Asthma-COPD overlap syndrome (ACOS)
- Step-up from ICS monotherapy when symptoms or exacerbations persist
Seroflo Multihaler Dosage
| Patient | Doza | Frecvență |
|---|---|---|
| Adults — moderate | 1 inhalation 100/50 | Twice daily |
| Adults — severe | 1 inhalation 250/50 | Twice daily |
| Adults — COPD | 1 inhalation 250/50 | Twice daily |
How to Use Seroflo Multihaler Properly
- Hold the Multihaler upright. Slide the cover down to load a dose.
- Listen for the click — confirms dose readiness.
- Breathe out fully away from the device.
- Seal lips around the mouthpiece.
- Inhale forcefully and deeply.
- Remove, hold breath 10 seconds, breathe out gently.
- Slide the cover up to close.
- Rinse mouth and spit; check the dose counter.
Side Effects of Seroflo Multihaler
Common (mostly local from ICS, plus some β2 effects from LABA):
- Oral thrush (white candidal plaques in mouth or throat)
- Hoarse voice / dysphonia
- Mild tremor (LABA effect; less than with high-dose SABA)
- Palpitations or heart rate increase (≤10 bpm at standard dose)
- Dureri de cap
- Throat irritation, mild cough on inhalation
Mai puțin frecvente:
- Mild reduction in growth velocity in children at high doses
- Easy bruising at high cumulative ICS doses
- Hypokalaemia at high LABA doses (with diuretics, theophylline, oral steroids)
- Pneumonia in COPD users (slight ICS-related increase)
- Adrenal suppression with high doses or strong CYP3A4 inhibitor co-prescription
Serious (stop and seek emergency help):
- Severe allergic reaction / anaphylaxis
- Paradoxical bronchospasm
- Severe palpitations, chest pain, irregular heartbeat
- Adrenal crisis during illness or surgery
Avertismente și precauții
- Use every day, even when you feel well. The benefit accumulates over 1–2 weeks; symptoms return within days of stopping.
- Never use the LABA component alone in asthma — LABA without ICS carries a higher risk of severe asthma death. {$brand} contains both components, so this is not an issue with this product.
- {$brand} is not a rescue inhaler (use Asthalin or Levolin for acute attacks).
- Rinse mouth, gargle, and spit out after every dose; brush teeth before bed.
- COPD users: ICS slightly raises pneumonia risk — ensure ICS adds value (eosinophilic phenotype, frequent exacerbations).
- Inhibitori puternici ai CYP3A4 (ritonavir, ketoconazole, itraconazole, clarithromycin) raise systemic exposure of both components — avoid prolonged co-prescription.
- Sarcină și alăptare: Budesonide-formoterol has the most pregnancy data; uncontrolled asthma is far more dangerous than the medication.
- Cardiovascular disease: use cautiously in severe coronary artery disease, arrhythmias, hyperthyroidism, severe heart failure.
Contraindicații
- Known hypersensitivity to fluticasone propionate, salmeterol, or any formulation excipient
- Untreated active fungal, bacterial, mycobacterial (TB), or viral respiratory infection
- Severe hypersensitivity to lactose or milk proteins (DPI formulations contain lactose)
- Acute asthma attack — use a SABA reliever instead
Interacțiuni medicamentoase
| Interacting drug | Efect | Ce să faceți |
|---|---|---|
| Strong CYP3A4 inhibitors (ritonavir, ketoconazole, itraconazole, clarithromycin) | Raise systemic ICS exposure → adrenal suppression / Cushing risk | Avoid; monitor cortisol if essential |
| Non-selective beta-blockers (propranolol, timolol drops) | Block LABA effect — risk of severe bronchospasm | Avoid; switch to cardioselective if essential |
| Loop or thiazide diuretics | Additive hypokalaemia from LABA | Monitor potassium with high doses |
| Theophylline / aminophylline | Additive tachycardia and hypokalaemia | Monitor heart rate and potassium |
| MAOIs and tricyclic antidepressants | Potentiate LABA cardiovascular effects | Caution — monitor BP/HR |
Depozitare
- Store below 25°C in a dry place. Keep desiccant in the bottle.
- Do not store in the bathroom — humidity makes the powder clump and reduces dose delivery.
- Once the strip/blister is opened, use within the period stated on the leaflet (typically 2–3 months).
- Keep out of reach of children.
Alternative conexe pe MedsBase
- Budecort Inhaler — budesonide ICS preventer
- Asthalin Inhaler — salbutamol reliever
- Tiova Inhaler — tiotropium LAMA for COPD
- Montair — montelukast LTRA add-on
- Duolin Inhaler — salbutamol + ipratropium combo reliever
Întrebări frecvente
Is Seroflo the same as Seretide or Advair?
Yes — all three contain fluticasone propionate + salmeterol. Seretide (GSK, EU/UK), Advair (GSK, US), Seroflo (Cipla, India). Clinically interchangeable at equivalent strength pairs.
Why is Seroflo a preventer and not a rescue inhaler?
The salmeterol component has slow onset (15–30 minutes) — it does not relieve acute breathlessness. For acute attacks, use a separate SABA reliever (Asthalin, Levolin). Take Seroflo every day to prevent attacks.
How long until Seroflo starts to work?
Some lung function gain by day 1; symptom improvement by week 1; full preventer effect by 2–4 weeks of consistent twice-daily use.
Why must I rinse my mouth after Seroflo?
Local steroid deposition can cause oral thrush and hoarseness. Rinsing, gargling, and spitting after every dose largely prevents both.
Can children use Seroflo?
Yes from age 4 — typically at 50/25 or 100/25 strength via inhaler with spacer + mask. Higher strengths reserved for older children and adults.
Is Seroflo safe in pregnancy?
Fluticasone has reassuring observational data in pregnancy. Budesonide-formoterol (Foracort) has more data; some prescribers prefer that combination during pregnancy. Uncontrolled asthma is more dangerous than either drug.
Can I use Seroflo as a SMART/MART reliever?
No — salmeterol has slow onset and is not licensed for as-needed use. Only formoterol-containing combinations (Foracort, Symbicort) can be used as SMART/MART.
How long does a Seroflo Inhaler last?
A 120-actuation canister lasts 60 days at twice-daily dosing. Rotacaps come in blister packs; check the leaflet for actuations per pack.
What’s the difference between Seroflo Inhaler, Rotacaps, Multihaler, Autohaler, Accuhaler?
All deliver fluticasone + salmeterol but use different devices and dose strengths. Inhaler = pressurised aerosol with spacer-friendly dosing. Rotacaps = single-dose dry powder via Rotahaler. Multihaler = multi-dose dry powder. Autohaler = breath-activated MDI (no need to coordinate). Accuhaler = multi-dose blister-strip dry powder. Choose based on your inspiratory ability and coordination.
Alternative conexe
Alte produse din Afecțiuni cronice pe care clienții le vizualizează de asemenea:
More options in Asthma/COPD Treatment
Clasificate în funcție de volumul recent de comenzi MedsBase — ce aleg alți clienți în această categorie.
| Concentrație | 50+500 mcg |
|---|---|
| Cantitate | 1 Inhaler/s, 2 Inhaler/s, 3 Inhaler/s, 6 Inhaler/s |
Seroflo Multihaler
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Seroflo Multihaler
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