Martifur
✅ Treats urinary infections
✅ Prevents bacterial growth
✅ Quick symptom relief
✅ Safe for consumption
✅ Easy to administer
✓ Medicinskt granskad av Morgan Ellis — Apoteksforskare · 8 års erfarenhet · Senast granskad: maj 2026
⚡ Quick Answer — What is Martifur?
Martifur is a nitrofurantoin modified-release capsule (100 mg, Martin & Brown) — a urinary-tract-specific antibiotic for uncomplicated lower UTI in women (5-day course) and recurrent UTI prophylaxis (3–6 months). NOT for pyelonephritis or any non-urinary infection. Avoid in CrCl < 45.
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How Martifur works
Martifur contains nitrofurantoin, a urinary-tract-specific antibiotic activated by bacterial nitroreductases inside the urine. The active intermediates damage bacterial ribosomes, DNA, and respiratory enzymes, killing the cell. Therapeutic concentrations are achieved only in the urine — nitrofurantoin is NOT useful for pyelonephritis (kidney parenchymal infection) or any non-urinary infection. Spectrum: most uropathogenic E. coli, Staphylococcus saprophyticus, Enterococcus faecalis, some Klebsiella. Resistance is naturally rare and slow to emerge; intrinsic resistance in Proteus, Serratia, Pseudomonas, Acinetobacter.
Indications & dosing
| Indikation | Dos | Varaktighet |
|---|---|---|
| Uncomplicated lower UTI in women | 100 mg twice daily (modified-release) OR 50 mg four times daily | 5 days (women) / 7 days (men) |
| UTI prophylaxis (recurrent UTI in non-pregnant women) | 50–100 mg at bedtime | 3–6 months then reassess |
| Asymptomatic bacteriuria in pregnancy (avoid at term) | 100 mg twice daily | 5–7 days |
Renal cut-off: contraindicated when CrCl < 45 mL/min — at lower clearances, urinary concentrations are sub-therapeutic and serum levels rise (toxicity risk). Most guidelines now use 60 mL/min as a more cautious threshold in older adults.
Take with food. Food increases bioavailability ~40% and reduces GI upset.
Long-term nitrofurantoin (months to years for prophylaxis) carries a small but real risk of chronic interstitial pneumonitis / pulmonary fibrosis (cough, dyspnoea, weight loss — irreversible if missed); chronic active hepatitis (often presents with autoimmune features); and peripheral neuropathy (usually reversible if caught early — risk higher in renal impairment, diabetes, B-vitamin deficiency). Patients on long-term prophylaxis should have baseline spirometry, LFTs, and clinical neuro review at 6-monthly intervals. Avoid in third trimester of pregnancy and in neonates < 1 month — risk of haemolytic anaemia in infants with G6PD deficiency.
Biverkningar
- GI: nausea, anorexia (taking with food halves the rate).
- Acute pulmonary reaction: sudden cough / dyspnoea / fever / eosinophilia in days to weeks of starting; usually reversible.
- Chronic pulmonary fibrosis: after months / years; may be irreversible.
- Hepatotoxicity: acute hepatitis or chronic active autoimmune-like hepatitis.
- Peripheral neuropathy: ascending paraesthesia / weakness in renal impairment.
- Haemolytic anaemia: in G6PD deficiency, or in neonates / late-pregnancy fetuses.
- Brown urine: harmless.
Kontraindikationer
- CrCl < 45 mL/min (more cautious 60 mL/min in elderly).
- Pregnancy at term (38–42 weeks) and during labour — neonatal haemolysis risk.
- Neonates < 1 month.
- G6PD deficiency.
- Pyelonephritis or any non-urinary infection — therapeutic levels cannot be achieved.
Läkemedelsinteraktioner
| Läkemedel | Effekt | Action |
|---|---|---|
| Antacids containing magnesium trisilicate | Adsorbs nitrofurantoin, reduces absorption | Avoid combination |
| Quinolones (fluoroquinolones) | Possible antagonism in vitro | Avoid combining for the same infection |
| Probenecid / sulfinpyrazone | Reduces urinary excretion → lower urinary, higher serum levels (more toxicity, less efficacy) | Avoid combination |
Pregnancy & Breastfeeding
Nitrofurantoin is widely used in early pregnancy for asymptomatic bacteriuria. Avoid in the last trimester (38–42 weeks) and during labour — risk of neonatal haemolytic anaemia. Also avoid in lactation if the infant has G6PD deficiency.
Förvaring
Store below 25 °C, away from direct sunlight and moisture. Keep in original packaging. Keep out of reach of children. Discard any unused tablets after the printed expiry date — degraded antibiotics can lose potency or release breakdown products.
This medicine is only effective against bacterial infections. Do not use it for viral illnesses (common cold, most sore throats, flu, COVID-19), do not stop early when you feel better, and do not save leftovers for future infections. Misuse drives drug-resistant bacteria like MRSA, ESBL, and CRE — the WHO ranks antimicrobial resistance among the top 10 global public-health threats.
Vanliga frågor
Can I use Martifur for a kidney infection?
No — nitrofurantoin reaches therapeutic levels only in urine. For pyelonephritis (kidney parenchymal infection) you need a tissue-penetrating agent (cephalosporin, fluoroquinolone, TMP-SMX based on local susceptibility).
Should I take it with food?
Yes — taking with food increases absorption ~40% and roughly halves the rate of nausea.
Why is my urine brown?
Harmless metabolite. It reverses after the course finishes.
Why is it avoided in older patients with reduced kidney function?
Nitrofurantoin is excreted renally; with reduced kidney function urinary levels are too low to clear infection AND serum levels rise (toxicity). Most guidelines avoid use below CrCl 60 mL/min.
How long do I take it?
Standard course is 5 days for women with uncomplicated UTI. Men need 7 days. Prophylaxis (recurrent UTI) is usually 3–6 months at low dose with regular review.
Will it interact with my other medications?
Antacids containing magnesium trisilicate adsorb the drug and reduce absorption — separate. Probenecid raises serum nitrofurantoin levels — avoid combination. Few other clinically important interactions.
Can I take it during pregnancy?
Yes in early-to-mid pregnancy. Avoid in the last trimester (after 38 weeks) and during labour — neonatal haemolysis risk.
Will it cover Pseudomonas or Proteus?
No — nitrofurantoin is intrinsically inactive against Proteus, Serratia, Pseudomonas, and Acinetobacter. Use a different agent based on culture.
What about long-term use for recurring UTIs?
Long-term low-dose prophylaxis is effective but requires baseline spirometry and LFTs, and 6-monthly clinical review for pulmonary, hepatic, and neuropathic adverse effects.
What if I have G6PD deficiency?
Avoid nitrofurantoin — risk of haemolytic anaemia. Use a different agent based on culture and renal function.
Other Antibiotics & Anti-Infective Medications
- Augmentin (Amoxicillin + Clavulanic acid) — broader spectrum
- Cetil (Cefuroxime) — second-generation cephalosporin
- Azee (Azithromycin) — penicillin-allergy alternative for respiratory infection
- Cifran (Ciprofloxacin) — fluoroquinolone for UTI / GI
- Doxt (Doxycycline) — atypical pneumonia / STIs
More options in Antibiotics
Rangerade efter senaste ordervolym på MedsBase — vad andra kunder i denna kategori väljer.
| Styrka | 50 mg, 100 mg |
|---|---|
| Kvantitet | 30 Tablet/s, 60 Tablet/s, 90 Tablet/s, 28 Tablet/s, 56 Tablet/s, 84 Tablet/s |
| Type | Martifur, Martifur MR |
| Pharma Form | Tablet/s |
| Manufacturer | Walter Bushnell |
| Treatment | Bacterial infections of urinary tract |
| Generic Brand | Nitrofurantoin |
Martifur
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