Selgin
✅ Manages Parkinson’s symptoms
✅ Enhances mood
✅ Növeli a dopaminszintet
✅ Javítja a motoros funkciókat
✅ Lassítja a betegség előrehaladását
Selgin contains Selegiline Hydrochloride.
✓ Orvosi ellenőrzés Morgan Ellis — Gyógyszerkutató · 8 év tapasztalat · Utolsó felülvizsgálat: 2026 május
⚡ Gyors válasz
Selgin orális selegiline (5 mg) tablet — a selective monoamine oxidase type B (MAO-B) inhibitor 2-es típusú diabetes kezelésére használják Parkinson-kór. By blocking MAO-B in the brain, it slows the breakdown of dopamine and helps lengthen the time levodopa keeps working between doses (reduces “off” time). Selegiline is metabolised to L-amphetamine and L-methamphetamine, which can contribute to insomnia — take morning doses only. Common side effects: insomnia, headache, dyskinesia, dry mouth, postural hypotension. Fontos: avoid combination with most antidepressants (SSRIs, SNRIs, TCAs), opioids such as pethidine and tramadol, and dextromethorphan — risk of szerotonin szindróma.
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Miért rendelj a MedsBase-ról
Generikus gyógyszereink WHO-GMP minősítésű gyártóktól származnak, és diszkrét, egyszerű csomagolásban szállítjuk őket világszerte — a csomagon nem szerepel a gyógyszer neve. A kártyás fizetések egy szabályozott feldolgozón keresztül történnek (a számlaleírások egy szabályozott kártyafizetési feldolgozót tartalmaznak — soha nem “MedsBase” vagy bármilyen gyógyszer neve). Kriptovalutát és SEPA banki átutalást is elfogadunk. Minden rendelést a Reshipment Assurance Policy biztosíték fedez.
What Is Selgin?
Selgin is an oral tablet containing selegiline 5 mg. selegiline is a selective monoamine oxidase type B (MAO-B) inhibitor originally introduced as Eldepryl / Jumex. Selgin is manufactured by a WHO-GMP certified facility and is bioequivalent to the originator brand at the same strength.
Selegiline was the first MAO-B inhibitor used in Parkinson disease, in clinical use since the 1980s. It can be used as monotherapy in early Parkinson disease (modest symptomatic benefit, may delay the need for levodopa by months) or as adjunct to levodopa to reduce “wearing-off” between doses. Its distinctive feature among MAO-B inhibitors is that it is metabolised to amphetamine derivatives, which contribute to a mild stimulant effect — useful for fatigue but a frequent cause of insomnia.
How Does Selgin (selegiline) Work?
In the brain, dopamine is degraded mainly by monoamine oxidase type B (MAO-B). Selegiline irreversibly inactivates MAO-B at standard doses (5–10 mg/day), so dopamine released from surviving neurones lingers longer in the synapse. The result: smoother symptom control and a longer benefit from each levodopa dose. Selegiline is also metabolised to L-amphetamine and L-methamphetamine, which independently contribute mild stimulant and dopaminergic effects. Above 10 mg/day, selectivity for MAO-B is lost and MAO-A inhibition becomes clinically meaningful — tyramine restriction then becomes important.
Comparing the MAO-B Inhibitors
The three MAO-B inhibitors used in Parkinson disease — selegiline, rasagiline and safinamide — share a common mechanism but differ meaningfully in metabolites, dosing and clinical positioning:
| Jellemző | Selegiline | Rasagiline | Safinamide |
|---|---|---|---|
| Tipikus adag | 5–10 mg/day | 0.5–1 mg/day | 50–100 mg/day |
| Active metabolites | Amphetamine + methamphetamine | Aminoindan (non-amphetamine) | No active stimulant metabolite |
| Glutamate effect | Nem | Nem | Igen — sodium-channel/glutamate-release modulation |
| Agoprex is a 25 mg agomelatine tablet supplied by Sun Pharma. Agomelatine is mechanistically unique among antidepressants: it acts as an agonist at melatonin MT1 and MT2 receptors and an antagonist at 5-HT2C serotonin receptors. The dual mechanism resynchronises disrupted circadian rhythms (a feature of major depression) while indirectly increasing dopamine and noradrenaline release in the frontal cortex. | Monotherapy or adjunct | Monotherapy or adjunct | Adjunct only — for fluctuating PD on levodopa |
| Insomnia risk | Higher (amphetamine metabolites) | Alacsony | Alacsony |
Who Is Selgin For?
Selgin is appropriate for adults with Parkinson disease — either as initial monotherapy in early disease (when symptoms are mild and the patient is reluctant to start levodopa) or as adjunct to levodopa in patients with end-of-dose “wearing-off”. Older patients prone to insomnia may tolerate rasagiline or safinamide better. Not appropriate during current SSRI/SNRI/TCA therapy or for patients planning to take pethidine, tramadol or other contraindicated medications.
Dózis és alkalmazás
A szokásos felnőtt adag 5 mg once daily with breakfast, increased to 5 mg twice daily (breakfast and lunch) after 1–2 weeks if needed for symptom control. Avoid evening doses — the amphetamine metabolites cause insomnia. Maximum 10 mg/day at standard MAO-B selectivity. Doses up to 20–30 mg/day have been used historically but cross into non-selective MAO inhibition with full tyramine-diet implications.
| Fázis | Dose | Időzítés |
|---|---|---|
| Week 1–2 (initiation) | Napi egyszer 5 mg | With breakfast |
| Karbantartó adag | 5 mg naponta kétszer | Breakfast and lunch — never evening |
| Maximum at MAO-B selectivity | 10 mg/day | Beyond this, tyramine restriction needed |
Gyakori mellékhatások
Insomnia (very common — the most common reason for discontinuation), headache, nausea, dizziness, postural hypotension, dry mouth, increased liver enzymes. Less common: confusion, hallucinations, agitation, mood changes. With levodopa: increased dyskinesia, may need to lower the levodopa dose by 10–30%.
Gyógyszer-étel kölcsönhatások
- Antidepressants — SSRIs, SNRIs, TCAs: avoid. If a serotonergic antidepressant is essential, mirtazapine or bupropion are sometimes used cautiously under specialist supervision.
- Opioids — pethidine, tramadol, methadone: contraindicated. Morphine, codeine, oxycodone are safer alternatives if analgesia is required.
- Sympathomimetics — pseudoephedrine, phenylephrine, ephedrine: risk of hypertensive crisis. Avoid OTC decongestants.
- Other MAO inhibitors — phenelzine, tranylcypromine, isocarboxazid, linezolid, methylene blue: contraindicated.
- CYP1A2 inducers/inhibitors — selegiline is metabolised by multiple CYP enzymes; clinically significant interactions are uncommon at MAO-B selective doses.
- Levodopa — intentional combination: start at the lower MAO-B dose and watch for dyskinesia (a sign that levodopa effect has been amplified). Levodopa dose may need a 10–30% reduction.
Gyakran Ismételt Kérdések
Can I take Selgin instead of levodopa?
Yes, especially in early Parkinson disease. Selegiline as monotherapy gives modest symptom benefit and may delay the need for levodopa by months. As disease progresses, levodopa is almost always added.
How quickly will I feel an effect?
MAO-B inhibitors work gradually. Most patients notice a smoother “on” period and reduced “off” time within 2–4 weeks. The full benefit on motor fluctuations is usually clear by 4–8 weeks.
Will I have to follow a low-tyramine diet?
At normal prescribed doses (selegiline ≤ 10 mg/day, rasagiline 1 mg/day, safinamide ≤ 100 mg/day), no special diet is required. Above those doses, MAO-B selectivity is lost and tyramine restriction becomes important.
Does Selgin slow down Parkinson disease itself?
A neuroprotective or disease-modifying effect of MAO-B inhibitors has been studied (e.g. the DATATOP and ADAGIO trials with selegiline and rasagiline). Results are suggestive but not definitive. The drugs are prescribed primarily for symptom control, not as guaranteed disease-modifying therapy.
Mi a teendő, ha kihagyok egy adagot?
A kihagyott adagot vegye be, amint eszébe jut that day. If it is already evening or close to bedtime, skip it — selegiline and rasagiline can both cause insomnia, and a late dose can disrupt sleep. Never double-dose. Resume normal schedule the next day.
Can I drink alcohol with Selgin?
Moderate alcohol is not strictly forbidden, but heavy drinking and red-wine binges can interact with residual MAO inhibition and increase blood-pressure variability. Many Parkinson patients also have postural hypotension on dopaminergic therapy — alcohol worsens this. Limit to 1 standard drink occasionally.
Can I drive while taking Selgin?
Most patients tolerate Selgin without driving impairment. However, dopaminergic therapy as a whole can cause sudden-onset sleep (sleep attacks), particularly when Selgin is added to a dopamine agonist or levodopa. Until you know how you respond, avoid driving long distances or operating heavy machinery.
Is Selgin safe in older adults?
Yes — selegiline is widely used in elderly Parkinson patients. Watch for postural hypotension (rise from sitting slowly), confusion, hallucinations, and impulse-control changes. Lower starting doses may be appropriate.
Can Selgin be stopped abruptly?
No. Sudden withdrawal of any dopaminergic agent in a Parkinson patient can precipitate a neuroleptikus malignus szindróma-szerű állapotot with rigidity, fever and altered consciousness. If discontinuation is needed, taper over 1–2 weeks under medical supervision.
Will Selgin cause weight loss or weight gain?
Neither markedly. Some patients on selegiline lose a small amount of weight (the amphetamine-like metabolites can suppress appetite slightly). Rasagiline and safinamide are weight-neutral.
How does MedsBase ship Selgin?
Diszkrét csomagolásban történő világszerte szállítás WHO-GMP tanúsítvánnyal rendelkező gyártótól. A tabletták eredeti, lezárt blistercsomagolásban kerülnek kiszállításra. A rendelését a MedsBase fiókjából követheti nyomon.
Tárolás
Tárolás szobahőmérsékleten (15–30°C), hőtől, nedvességtől és közvetlen fénytől védve. Az eredeti dobozban, szorosan lezárt fedővel tárolandó. Tartsa gyermekek szeme elől távol. Ne használja fel a csomagoláson feltüntetett lejárati dátum lejárta után.
Orvosi felelősségi nyilatkozat
Ez az információ kizárólag oktatási célokat szolgál, és nem helyettesíti a képzett klinikus tanácsát. A Parkinson-kór és a parkinsonizmus egyéni neurológiai kezelést igényel. Beszélje meg minden gyógyszerét, táplálék-kiegészítőjét és előzetes betegségeit orvosával a kezelés megkezdése, módosítása vagy leállítása előtt. Ne szakítsa meg hirtelen a dopaminerg terápiát – a hirtelen elvonás neuroleptikus malignus szindrómához hasonló állapotot válthat ki.
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| Erősség | 5 mg |
|---|---|
| Mennyiség | 30 tabletta, 60 tabletta, 90 tabletta, 180 tabletta |
Selgin
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Selgin
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