Lurasid
Lurasid (Lurasidone 20/40/80 mg) — 5-HT7-active atypical for schizophrenia and bipolar depression. food-rule mandatory — fasting halves bioavailability.
✓ Zweryfikowany medycznie przez Morgan Ellis — Badacz farmaceutyczny · 8 lat doświadczenia · Ostatnia weryfikacja: maj 2026
⚡ Szybka odpowiedź
Lurasid (Lurasidone 20 / 40 / 80 mg) is an atypical antipsychotic for schizophrenia and bipolar depression. Must be taken with food (≥ 350 kcal) — fasting halves absorption and produces treatment failure. Metabolically among the cleanest atypicals.
📦 Każde zamówienie jest objęte naszą Reshipment Assurance Policy — jeśli Twoja przesyłka nie dotrze w ciągu 20 dni roboczych, wysyłamy ją ponownie.
Dlaczego warto zamawiać z MedsBase
Lurasid at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our Reshipment Assurance Policy — 20-dniowym terminem dostawy lub wysyłamy ponownie bez dodatkowych kosztów — i kwalifikuje się do naszego programu lojalnościowego. Dostawa na całym świecie dostępna jest do większości krajów.
What Lurasid is and how it works
Lurasid is a lurasidone tablet supplied by Sun Pharma. Available strengths: 20 / 40 / 80 mg. Lurasidone is a D2/5-HT2A antagonist with additional 5-HT7 antagonism (the 5-HT7 component is the basis for its bipolar-depression indication). It is one of the cleanest atypicals on metabolic markers — minimal weight gain, minimal lipid effect, minimal glucose effect.
Fasting bioavailability of lurasidone is approximately half the fed bioavailability. Patients who skip a meal or take the dose at a small snack reach inadequate plasma levels and frequently appear to “fail” therapy. Take with the largest meal of the day, every day, at the same time. A glass of milk or a small biscuit is not enough — aim for at least 350 kcal of mixed-macronutrient food.
Wskazania i dawkowanie
| Wskazanie | Początkowa | Docelowa | Maksymalna |
|---|---|---|---|
| Schizofrenia (dorośli) | 40 mg OD with food | 40–80 mg OD | 160 mg |
| Schizofrenia (młodzież ≥ 13 lat) | 40 mg OD with food | 40–80 mg OD | 80 mg |
| Bipolar depression (adult, monotherapy or adjunct) | 20 mg OD with food | 20–60 mg OD | 120 mg |
| Bipolar depression (paediatric ≥ 10 y) | 20 mg OD with food | 20–80 mg OD | 80 mg |
| Niewydolność nerek (CrCl < 50) | 20 mg OD with food | up to 80 mg | 80 mg |
Ważne kwestie bezpieczeństwa
Wszystkie atypowe leki przeciwpsychotyczne posiadają ostrzeżenie FDA black-box dotyczące zwiększonej śmiertelności (głównie sercowo-naczyniowej i infekcyjnej) przy stosowaniu w leczeniu zaburzeń behawioralnych u starszych osób z demencją. Atypowe leki przeciwpsychotyczne nie są zatwierdzone do leczenia psychozy lub pobudzenia związanych z demencją.. Stosowanie w tej populacji jest poza wskazaniami, ostatecznością, ograniczone czasowo i wymaga wyraźnej rozmowy na temat ryzyka i korzyści.
Akathisia is common at higher doses. EPS (rigidity, tremor, dystonia) less common than first-generation antipsychotics but can occur. Manageable with dose reduction or anticholinergic adjunct.
Avoid concurrent strong CYP3A4 inhibitors (azoles, clarithromycin, ritonavir, grapefruit juice) — they raise lurasidone levels several-fold. Avoid strong inducers (rifampicin, carbamazepine, phenytoin, St John’s wort) — they reduce levels into the ineffective range.
All antidepressant-class indications carry the under-25 suicidality warning.
Typowe działania niepożądane
- Somnolence and sedation — common; usually settles.
- Akatyzja — zależne od dawki.
- Nudności — first 1–2 weeks; mitigated by food (which is mandatory anyway).
- EPS — uncommon but possible.
- Przyrost masy ciała — modest, generally less than olanzapine/quetiapine.
- Prolaktyna — small dose-dependent rise.
- Charakterystyczne zalety: minimal effect on lipids, glucose, QT.
Interakcje lekowe
- Silne inhibitory CYP3A4 — contraindicated.
- Silne induktory CYP3A4 — contraindicated.
- Moderate CYP3A4 inhibitors (diltiazem, verapamil, fluconazole, erythromycin) — halve lurasidone dose; max 40 mg.
- Other CNS depressants — additive sedation.
- Other antipsychotics — additive EPS, prolactin, NMS risk.
Ciąża, karmienie piersią, pediatria
Pregnancy: limited data; weigh against untreated illness. Breastfeeding: insufficient data; generally avoided. Paediatric: licensed from 13 (schizophrenia), 10 (bipolar depression).
Przechowywanie
Przechowywać w temperaturze 15–30 °C w oryginalnym opakowaniu.
Najczęściej zadawane pytania
Why does Lurasid need to be taken with food?
Fasting absorption is approximately half of fed absorption. The food requirement is not optional — patients who take Lurasid on an empty stomach often appear to fail therapy when in fact they are simply under-dosed. The minimum threshold for adequate absorption is approximately 350 kcal of mixed food (a normal meal, not a snack).
Why is Lurasid preferred for bipolar depression?
Lurasidone has FDA approval for bipolar depression as monotherapy or adjunct (PREVAIL-2 trial) — one of only three atypicals with this indication (others are quetiapine and olanzapine-fluoxetine). The 5-HT7 antagonism is thought to underlie the antidepressant effect. Lurasidone is a metabolically cleaner choice than quetiapine or olanzapine for bipolar depression.
Will Lurasid make me gain weight?
Less than olanzapine, clozapine, quetiapine, or risperidone — typically 1–2 kg over 6 months in monotherapy. One of the better metabolic profiles among atypicals.
How long until Lurasid works?
Schizophrenia: positive symptoms typically improve over 2–4 weeks; full effect at 4–6 weeks. Bipolar depression: 2–6 weeks for full effect. Compliance with the food requirement matters — if response is poor, check that doses are being taken with adequate meals.
Can Lurasid be combined with mood stabilisers?
Yes — lurasidone is FDA-approved as an adjunct to lithium or valproate in bipolar depression. Combination is common and well-tolerated.
What about driving on Lurasid?
Sedation is dose-dependent. Most patients on stable doses drive normally; the first 1–2 weeks of titration can impair reaction time.
How is Lurasid different from olanzapine?
Lurasidone has a substantially better metabolic profile (less weight gain, less glucose disturbance, less lipid disturbance) but a slightly higher rate of akathisia and somnolence. Olanzapine is more sedating and has stronger acute antipsychotic effect; lurasidone is preferred for long-term metabolic safety.
Can Lurasid be stopped abruptly?
Generally taper over 1–2 weeks, although withdrawal is mild. The relapse risk in schizophrenia and bipolar disease is the main reason for caution — never stop without prescriber agreement.
Why is grapefruit juice a problem?
Grapefruit juice is a strong CYP3A4 inhibitor. Lurasidone is a CYP3A4 substrate; grapefruit raises levels several-fold, increasing sedation, akathisia, and EPS risk. Avoid grapefruit and grapefruit juice during Lurasid therapy.
Does Lurasid prolong the QT interval?
Less than ziprasidone, less than thioridazine. Lurasidone has a small QT signal but is generally regarded as one of the cleaner atypicals for QT. Pre-treatment ECG is not routinely required but is reasonable in patients with cardiac risk factors.
Inne leki na zdrowie psychiczne
- Aripicon (Arypiprazol — częściowy agonista D2)
- Olanzap (Olanzapina — silny lek przeciwpsychotyczny)
- Risdone (Rysperydon)
- Seroquit (Kwetiapina — depresja dwubiegunowa)
- Atlura (Lurazydon — metabolicznie neutralny)
Więcej opcji w zakresie zdrowia psychicznego i leków psychiatrycznych
Ranking według liczby ostatnich zamówień MedsBase — co wybierają inni klienci w tej kategorii.
| Moc | 80 mg |
|---|---|
| Ilość | 30 tabletek, 60 tabletek, 90 tabletek, 180 tabletek |
Lurasid
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Lurasid
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