Gestoford

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What Is Gestoford?

Gestoford is a branded generic of micronized progesterone, a bioidentical form of the natural progesterone hormone produced by the ovaries. “Micronized” means the progesterone particles are reduced to tiny sizes to improve oral absorption (regular crystalline progesterone is poorly absorbed).

Micronized progesterone differs from synthetic progestins (medroxyprogesterone, norethindrone, levonorgestrel). Synthetic progestins have stronger androgenic or anti-androgenic effects and have been linked in large trials (WHI) to higher breast cancer risk when combined with estrogen. Bioidentical progesterone, in contrast, appears to have a neutral or slightly favourable profile in observational studies (E3N, French cohort) — though RCT evidence is less robust.

Strength: 100 mg. Fabricat de Zydus Cadila.

Utilizări clinice

• Progestin opposition in HRT: 100 mg daily (continuous-combined) or 200 mg for 10–14 days per cycle (sequential) when taking systemic estrogen in women with a uterus.
• Luteal phase support in IVF and assisted reproduction: 200–600 mg daily starting after egg retrieval.
• Recurrent miscarriage (selected cases, based on PRISM and PROMISE trial data — benefit in women with ≥3 previous miscarriages and current bleeding, not all-comers).
• Secondary amenorrhoea: progesterone challenge test to assess endometrial proliferation.
• Endometrial hyperplasia (simple, without atypia): 100–200 mg cyclical progesterone.
• Premenstrual syndrome / PMDD (limited evidence; less effective than SSRIs or drospirenone-containing COCs).

Cum se administrează

1. Luați at bedtime — progesterone causes drowsiness (via GABA-A receptor activity of its metabolite allopregnanolone). Many women use this sleep-inducing effect as a helpful HRT adjunct.
2. Swallow whole with water. With or without food — food slightly increases absorption.
3. HRT cyclic regimen: 100–200 mg daily on days 15–28 of each 28-day cycle (withdrawal bleed follows).
4. HRT continuous-combined regimen: 100 mg daily (every day, every month). No withdrawal bleed after 3–6 months.
5. Luteal support: 200–400 mg/day starting after egg retrieval or ovulation; vaginal administration is also used (off-label, better bioavailability, avoids drowsiness).
6. Do not crush — micronized formulation requires intact capsule for absorption properties.

Efecte Secundare

Frecvente: drowsiness (actually often desirable — see above), dizziness, fatigue, headache, breast tenderness, irregular bleeding (sequential regimen), bloating, mild mood effects.

Mai puțin frecvente: vaginal discharge, joint/muscle aches, allergic reactions.

Rare: cholestasis, jaundice, acute pancreatitis, increased risk of thrombosis (much less than synthetic progestins), dysphoric mood changes.

Who Should Not Take Gestoford

• Current or recent breast cancer (individualised — discuss with oncologist)
• Active liver disease
• Known or suspected pregnancy (unless used as pregnancy support with clinician guidance)
• Undiagnosed vaginal bleeding
• Known hypersensitivity to progesterone or excipients (peanut oil is a common excipient — beware if peanut-allergic)
• History of VTE — caution; synthetic progestins are higher risk than micronized

Micronized vs Synthetic Progestins — Why It Matters

Depozitare

Store at room temperature (15–25 °C / 59–77 °F), away from moisture and sunlight. Keep in original container. Keep out of reach of children.

Întrebări frecvente

Why take Gestoford at bedtime?

Progesterone is metabolised to allopregnanolone, which activates GABA-A receptors and causes drowsiness. Bedtime dosing turns a common side effect into a sleep benefit — many women report better sleep on cyclic progesterone as part of HRT.

Micronized vs synthetic progestin — which is better?

Micronized (bioidentical) progesterone appears to have a more favourable safety profile in observational studies (E3N French cohort), particularly for breast cancer. Synthetic progestins (medroxyprogesterone, levonorgestrel, norethindrone) are well-studied and effective but with slightly higher breast-cancer signal in large HRT trials (WHI). Discuss with a clinician.

Can I use Gestoford vaginally?

Yes — off-label vaginal use is common in IVF and fertility practice. Vaginal route bypasses first-pass metabolism, giving higher uterine concentrations and fewer side effects. For HRT use, oral is typical; discuss with a gynaecologist.

Do I need Gestoford if I've had a hysterectomy?

No. Progestin opposition is only needed to protect the uterine lining from estrogen-induced hyperplasia. Post-hysterectomy, estrogen alone is sufficient.

What if I get breakthrough bleeding?

Some breakthrough bleeding is normal in the first 3–6 months of continuous-combined HRT. Persistent or heavy bleeding beyond 6 months warrants clinical review (ultrasound +/- endometrial biopsy).

Can Gestoford help premenstrual symptoms?

Evidence is mixed. Some women benefit from cyclic progesterone for PMS/PMDD, but SSRIs (fluoxetine, sertraline) and drospirenone-containing COCs have stronger trial support. Progesterone is a reasonable option when SSRIs are not tolerated.

Does Gestoford cause weight gain?

Micronized progesterone is generally weight-neutral. Some women report mild fluid retention that resolves within 1–2 cycles.

Can I take Gestoford during pregnancy?

Progesterone is often used in early pregnancy for luteal support (IVF, recurrent miscarriage with current bleeding per PRISM trial). Use in pregnancy should be guided by a fertility specialist or obstetrician.

Related Hormone & Women’s Health Products

• Premarin (Conjugated Estrogens)
• Premarin Cream (Vaginal Estrogen)
• Progynova (Estradiol Valerate)
• Endogest (Progesterone 100 mg)
• Gestheal (Progesterone 200 mg)
• Susten Capsule (Progesterone)
• Susten Injection (Progesterone)

Alternative conexe

Alte produse din Women's Health pe care clienții le vizualizează de asemenea:

• Susten Vaginal Gel
• Yasmin
• Deviry
• Premarin
• Femalefil

More options in Hormone Replacement Therapy (HRT) Medication for Menopause

Clasificate în funcție de volumul recent de comenzi MedsBase — ce aleg alți clienți în această categorie.

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