Sazo

📦 Fiecare comandă este acoperită de politica noastră de Politica noastră de Reexpediere Garantată — dacă coletul dumneavoastră nu sosește în 20 de zile lucrătoare, îl relivrăm.

De ce să comanzi de la MedsBase

Medicamentele noastre generice sunt procurate de la producători certificați WHO-GMP și expediate la nivel mondial în ambalaje discrete și simple — fără denumirea medicamentului pe exteriorul coletului. Plățile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de plăți cu card reglementat — niciodată “MedsBase” sau numele vreunui medicament). Acceptăm și criptomonede și transferuri bancare SEPA. Fiecare comandă este susținută de Politica noastră de Asigurare pentru Relivrare.

What Is Sazo?

Sazo is an oral tablet containing sulfasalazine (500 mg), manufactured by WHO-GMP certified manufacturer. Supplied in packs of 30, 60, 90 or 180 tablets. Sulfasalazine has been in clinical use since the 1940s and was the first disease-modifying anti-inflammatory drug used in ulcerative colitis. It is on the WHO Essential Medicines List.

Sulfasalazine is a prodrog (azo-bonded sulfapyridine + 5-ASA). The intact molecule is not absorbed in the small intestine; gut bacteria in the colon cleave the azo bond, releasing both components. 5-ASA stays in the colon and acts locally (this is the UC effect); sulfapyridine is absorbed and circulates systemically (responsible for the RA effect and most of the side effects).

What Is Sazo Used For?

• Ulcerative colitis — induction and maintenance of remission in mild-to-moderate disease
• Crohn’s disease with colonic involvement (modest effect; pure mesalamine formulations or other agents usually preferred)
• Rheumatoid arthritis — a conventional disease-modifying antirheumatic drug (cDMARD) used alone or in combination with methotrexate and hydroxychloroquine
• Juvenile idiopathic arthritis
• Ankylosing spondylitis with peripheral joint involvement (modest effect)

Sazo is primește, for irritable bowel syndrome (IBS), which is a functional disorder and does not involve intestinal inflammation.

How Does Sazo Work?

After oral dosing, about 10–20% of sulfasalazine is absorbed in the small intestine; the rest reaches the colon intact. There, bacterial azoreductases cleave the azo bond, liberating:

• 5-aminosalicylic acid (5-ASA) — stays in the colon, exerts topical anti-inflammatory action via COX/LOX inhibition, ROS scavenging, NF-κB inhibition, and PPAR-γ agonism. This is the UC effect.
• Sulfapyridine — absorbed and circulates systemically; modulates immune function and is thought to contribute to the anti-rheumatic effect (the exact mechanism in RA is not fully understood but involves T-cell and cytokine modulation).

Because the cleavage happens in the colon, sulfasalazine delivers 5-ASA efficiently to colitis patients without needing an enteric coating — effectively an early “biological” colon-targeting system.

Doza și administrare

Ulcerative colitis (adults, induction): 500 mg four times daily for 1–2 weeks, then increase to 1 g four times daily (total 4 g/day). Maintenance: 2 g/day in divided doses.

Rheumatoid arthritis (adults): 500 mg/day for the first week, then increase by 500 mg/day each week to a maintenance of 2 g/day (maximum 3 g/day). Gradual titration is the single biggest predictor of tolerability.

Pediatric: weight-based; specialist prescribing only.

• Luați with or after food — reduces nausea.
• Înghițiți întreagă; enteric-coated tablets should not be crushed.
• Ensure adequate hydration (at least 1.5 L water/day) — reduces renal crystal risk.
• Check G6PD status before starting in high-risk populations (Mediterranean, African, Asian ancestry) — sulfapyridine can trigger haemolysis in G6PD-deficient patients.
• Monitorizare: FBC + LFT + U&E at baseline, every 2 weeks for 3 months, monthly for 3 months, then quarterly.
• Folic acid 5 mg weekly supplementation is recommended for long-term users — sulfasalazine inhibits folate absorption.

Efecte Secundare

Sulfasalazine’s side-effect profile is broader than pure mesalamine because of the sulfapyridine component. Most effects are dose-dependent and improve with slower titration.

Common (up to 30% of users in the first weeks):

• Nausea, dyspepsia, loss of appetite
• Dureri de cap
• Amețeli
• Orange-yellow discolouration of urine, tears, sweat, and (occasionally) skin — harmless but may stain contact lenses and clothing
• Mild reversible reduction in sperm count (~80% of male users) — counselling for patients trying to conceive

Puțin frecvente, dar importante:

• Haemolytic anaemia — particularly in G6PD deficiency. Screen where relevant.
• Neutropenia, agranulocytosis, thrombocytopenia — most common in the first 3–6 months; hence frequent FBC monitoring.
• Hepatită — raised transaminases usually mild; rare severe hepatitis.
• Renal effects — interstitial nephritis, crystalluria (hydrate well).
• Pulmonary reactions — eosinophilic pneumonitis, fibrosing alveolitis (rare).
• Severe cutaneous reactions — Stevens-Johnson syndrome, toxic epidermal necrolysis, DRESS. Opriți imediat if unexplained fever, rash, or mouth ulcers appear.
• Folate deficiency with long-term use — megaloblastic anaemia.

Interacțiuni medicamentoase

• Azathioprine / mercaptopurine — additive myelosuppression risk; monitor FBC.
• Metotrexat — additive myelosuppression; widely used combination in RA but requires close monitoring.
• Warfarin — sulfasalazine can raise INR; monitor.
• Digoxină — sulfasalazine reduces digoxin absorption; separate doses by at least 2 hours.
• Folic acid — absorption reduced; supplement with 5 mg weekly.
• Hipoglicemiante orale (glibenclamide, tolbutamide) — sulfasalazine may enhance hypoglycaemic effect.
• Vaccinuri cu virus viu — generally safe on sulfasalazine alone but avoid when combined with other immunosuppressants (azathioprine, biologics).

Who Should Not Take Sazo?

• Known hypersensitivity to sulfasalazine, sulfonamides, or salicylates (including aspirin)
• Intestinal or urinary obstruction
• Porfire
• Insuficiență renală sau hepatică severă
• G6PD deficiency — relative contraindication; use under specialist supervision with haemolysis monitoring
• Children below the label age cutoff
• Breastfeeding premature or ill infants — sulfasalazine enters breast milk; bilirubin displacement risk
• Pregnancy — generally continued when needed for UC control with folate supplementation; specialist input advised

Depozitare

Store Sazo below 25°C in a dry place, in the original blister. Keep out of reach of children. Protect from light.

Întrebări frecvente

Is Sazo the same as mesalamine?

Not quite. Sulfasalazine is a prodrug of mesalamine joined by an azo bond to sulfapyridine. In the colon, bacteria split it, releasing free mesalamine (which acts locally in UC) and sulfapyridine (which is absorbed and causes most of the systemic side effects). Pure mesalamine (Asacol, Mesacol) gives you the UC benefit without the sulfa. Sulfasalazine is preferred when you want both the UC effect și the anti-rheumatic effect — e.g. in UC patients who also have peripheral arthritis, or in pure rheumatoid arthritis.

Why does my urine turn orange on Sazo?

Sulfapyridine metabolites are coloured. Orange discolouration of urine, sweat, and sometimes tears is expected, harmless, and not an indication to stop. Do warn soft-contact-lens wearers — the pigment can stain lenses permanently.

Does Sazo affect fertility?

It causes reversible oligospermia in about 80% of male users (low sperm count, reduced motility). Sperm counts usually return to normal within 2–3 months of stopping. Men planning conception can switch to pure mesalamine (for UC) or another cDMARD (for RA). No similar effect has been described in women.

Can I take Sazo for IBS?

No — IBS is a functional disorder without bowel inflammation. Sulfasalazine has no role in IBS. For IBS, see mebeverine (Colospa) for cramps, rifaximin (Rifagut) for IBS-D, dietary intervention (low-FODMAP), or central modulators.

Do I need blood tests on Sazo?

Yes. Baseline FBC, LFTs, U&Es; then every 2 weeks for 3 months, monthly for the next 3 months, quarterly thereafter. This catches the rare but important blood, liver, and kidney adverse effects early.

Where can I buy Sazo online?

You can order Sazo (500 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide with discreet packaging and genuine WHO-GMP certified manufacturer stock.

Medicamente conexe pentru SII și BCI

• Mesacol — Mesalamină 400/800 mg (Sun Pharma)
• Asacol — Mesalamină 400 mg (Win-Medicare)
• Mesacol OD — Mesalamina o dată pe zi MMX
• Sazo — Sulfasalazină 500 mg
• Salazar — Sulfasalazină
• Colospa — Mebeverină 135 mg (antispastic pentru SII)
• Rifagut — Rifaximin (antibiotic selectiv intestinal)
• Răsfoiți toate medicamentele pentru SII și IBD

Alternative conexe

Alte produse din Afecțiuni cronice pe care clienții le vizualizează de asemenea:

• Angiotensin
• Ciclohale
• Voritrol
• Duovir N
• Anaridex

Mai multe opțiuni în tratamentul sindromului intestinului iritabil (SII)

Clasificate în funcție de volumul recent de comenzi MedsBase — ce aleg alți clienți în această categorie.

Mesacol

US$16.50 – US$55.60Fascia di prezzo: da US$16.50 a US$55.60

Colospa

US$39.00 – US$152.00Fascia di prezzo: da US$39.00 a US$152.00

Mesacol OD

US$69.00 – US$260.00Fascia di prezzo: da US$69.00 a US$260.00

Salazar

US$42.00 – US$162.00Fascia di prezzo: da US$42.00 a US$162.00