Theo-Asthalin

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De ce să comanzi de la MedsBase

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What Is Theo-Asthalin?

Theo-Asthalin is an oral methylxanthine bronchodilator. Methylxanthines are derived from natural alkaloids (theophylline is the dimethylxanthine present in tea). Their use has declined since the 1990s as inhaled β2-agonists and corticosteroids became first-line — but they retain a role as third-line add-on therapy in difficult asthma and COPD.

How Does Theo-Asthalin Work?

• Phosphodiesterase inhibition (PDE3, PDE4) — raises cyclic AMP in airway smooth muscle and inflammatory cells; net result is bronchodilation and reduced mediator release.
• Adenosine receptor antagonism — blocks adenosine-mediated bronchoconstriction and mast-cell mediator release.
• HDAC2 activation (theophylline at low serum levels 5–10 mg/L) — restores corticosteroid responsiveness in COPD and severe asthma where steroid resistance is partly mediated by reduced HDAC2.
• Diaphragm contractility — methylxanthines reduce diaphragm fatigue, useful in COPD with severe airflow limitation.

Utilizări și indicații

• Severe chronic asthma — add-on to high-dose ICS-LABA where additional bronchodilation is needed
• COPD maintenance — add-on to LAMA-LABA or triple therapy
• Nocturnal asthma — sustained-release formulation provides overnight bronchodilation
• Apnoea of prematurity (theophylline) — neonatal use
• Cor pulmonale and pulmonary hypertension — adjunct

Theo-Asthalin Dosage

Side Effects of Theo-Asthalin

• Nausea, vomiting, dyspepsia
• Dureri de cap
• Tremor
• Insomnia, restlessness
• Tachycardia, palpitations
• Mild hypokalaemia at high doses

Toxic levels (>20 mg/L) — emergency:

• Severe nausea, persistent vomiting
• Cardiac arrhythmia (atrial fibrillation, supraventricular tachycardia)
• Seizures (often without warning)
• Hypotension, hyperglycaemia, hypokalaemia, hypercalcaemia

Avertismente și precauții

• Narrow therapeutic index. Target serum 10–20 mg/L. Check blood level 5 days after starting, after dose change, with new interacting drug, with smoking cessation, and during illness/fever (clearance falls).
• Many drug interactions — see interactions table. Most metabolised by CYP1A2; many inhibitors and inducers shift levels significantly.
• Smoking induces CYP1A2 and lowers theophylline levels by ~50% — re-titrate at smoking cessation.
• Cardiac disease: use cautiously in arrhythmias, heart failure, severe hypertension.
• Hyperthyroidism: increased clearance plus exaggerated adrenergic effects.
• Sarcină și alăptare: generally avoided; use only if benefit clear.
• Liver disease: reduce dose — methylxanthines are hepatically metabolised.

Contraindicații

• Hypersensitivity to theophylline or other xanthines (caffeine, theobromine)
• Active peptic ulcer disease
• Uncontrolled tachyarrhythmias
• Severe heart failure (NYHA IV)

Interacțiuni medicamentoase

Depozitare

• Store below 25°C in a cool, dry place away from direct sunlight.
• Keep in original packaging until use to protect from moisture and light.
• Do not use after the expiry date printed on the strip.
• Keep out of reach of children.

Alternative conexe pe MedsBase

• Asthalin Inhaler — salbutamol reliever
• Budecort Inhaler — budesonide ICS preventer
• Foracort Inhaler — budesonide + formoterol ICS-LABA
• Tiova Inhaler — tiotropium LAMA for COPD
• Montair — montelukast LTRA tablet

Întrebări frecvente

Why combine theophylline with salbutamol?

The combination delivers β2 agonism (bronchodilation) plus methylxanthine effect (additional bronchodilation, anti-inflammatory, diaphragm contractility) in one tablet — historically convenient for compliance.

Is this combination still used?

Less commonly than separate components. Modern practice prefers inhaled therapy (β2 agonist + ICS) over oral combinations, both for safety (lower systemic exposure) and efficacy.

Are the side effects of both drugs additive?

Yes — tremor, tachycardia, headache, insomnia, hypokalaemia are amplified by both components. Monitor cardiovascular tolerance.

How fast does Theo-Asthalin start working?

Salbutamol component begins in 15–30 min; theophylline reaches steady state over days.

Can I take it with my inhaler?

Possibly — discuss with your prescriber. Stacking oral and inhaled β2-agonists can increase tremor, tachycardia, and hypokalaemia.

Will it interact with my heart medications?

Theophylline interacts with many drugs (see interaction table). Always tell your doctor what you are taking.

Is it safe in pregnancy?

Generally avoided; inhaled therapy is preferred.

How long does each tablet last?

Both components last 4–6 hours; dosing 3–4 times daily.

Can I crush the tablet?

Standard tablets can be crushed; controlled-release versions cannot. Check the label.

Alternative conexe

Alte produse din Afecțiuni cronice pe care clienții le vizualizează de asemenea:

• Xyzal
• Listril Plus
• Reactin
• Dilvas
• Glucored

More options in Asthma/COPD Treatment

Clasificate în funcție de volumul recent de comenzi MedsBase — ce aleg alți clienți în această categorie.

Asthalin

US$2.00 – US$8.00Gama de preços: US$2.00 a US$8.00

Aerocort Inhaler

US$6.00 – US$14.00Gama de preços: US$6.00 a US$14.00

Asthalin Respules

US$10.90 – US$27.50Gama de preços: US$10.90 a US$27.50