Nailrox Nail Lacquer
✅ Fights nail fungus
✅ Prevents fungal growth
✅ Strengthens nails
✅ Promotes nail health
✅ Easy topical application
Nailrox Nail Lacquer contains Ciclopirox.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
💡 Quick Answer
Nailrox Nail Lacquer is ciclopirox 8% w/v medicated nail lacquer — a hydroxypyridinone antifungal (mechanism distinct from azoles, allylamines, and morpholines) for onychomycosis caused by Trichophyton rubrum and T. mentagrophytes. Daily application during the first week then progressively less often (week 2 every 2 days, week 3+ once weekly), with weekly removal using nail polish remover. Treatment up to 48 weeks for toenails. Cure rates with topical alone are modest (~30%); combination with oral terbinafine improves outcomes.
WHO-GMP
certified manufacturer
📦 Every order is covered by our Reshipment Assurance Policy — if your parcel does not arrive within 20 business days, we reship it.
Why order from MedsBase
Our generic medications are sourced from WHO-GMP certified manufacturers and shipped worldwide in discreet, plain packaging — no medication name on the parcel exterior. Card payments are routed through a regulated processor (statement descriptors include a regulated card-payment processor — never “MedsBase” or any medication name). Crypto and SEPA bank transfer are also accepted. Every order is backed by our Reshipment Assurance Policy.
Discreet packaging
plain envelope
Worldwide shipping
to most countries
🔒 Why order Nailrox Nail Lacquer from MedsBase
- WHO-GMP certified manufacturer — sourced from a regulated facility, finished pack with batch number and expiry.
- Discreet packaging — plain envelope, no medication name on the outside.
- Worldwide shipping to most countries with Reshipment Assurance.
- Loyalty points — 1 point per $1 spent (excludes peptides/shipping); 100 points = $5 off your next order.
Uses
Nailrox Nail Lacquer (ciclopirox 8% w/v nail lacquer, Glenmark) is approved for mild-to-moderate onychomycosis caused by dermatophytes (Trichophyton rubrum, T. mentagrophytes). Like amorolfine, it is most effective for distal-edge disease that does not involve the nail matrix.
How to apply — schedule matters
| Week | Frequency |
|---|---|
| Week 1 | Apply once daily, ideally at bedtime |
| Week 2 | Apply every other day |
| Week 3 onwards | Apply once weekly |
| Once a week | Remove existing lacquer with nail polish remover, file the nail, then re-apply |
- File rough surface of the affected nails.
- Apply a thin layer to the entire nail and 5 mm of surrounding skin (drug also penetrates lateral nail folds).
- Wait 30 seconds to let it dry.
- Once weekly: use nail polish remover (acetone or ethyl acetate) to remove all built-up lacquer, file rough surface, then re-apply.
- Treatment may continue up to 48 weeks for toenails.
How it works
Ciclopirox is a hydroxypyridinone antifungal — chemically distinct from azoles, allylamines, and morpholines. It chelates trivalent metal cations (iron, aluminium) required by fungal mitochondrial enzymes. The result is impaired energy production and reduced uptake of essential precursors. Active against dermatophytes, Candida, Malassezia, and some bacteria — broader spectrum than most other topical antifungals. Penetrates the nail plate over weeks of repeat application.
Side effects
- Common — periungual erythema, mild burning at application, brittleness or shape change of the affected nail.
- Uncommon — contact dermatitis, onycholysis.
- Rare — severe contact allergy.
Pregnancy & breastfeeding
Limited data. Minimal systemic absorption. Onychomycosis is not life-threatening — many clinicians defer treatment until after pregnancy. Topical ciclopirox use in breastfeeding is generally considered low-risk; avoid hand-to-mouth contact with the infant after application.
Why order from MedsBase
- WHO-GMP certified manufacturer — sourced from a regulated facility, finished pack with batch number and expiry.
- Discreet packaging — plain envelope, no medication name on the outside.
- Worldwide shipping with Reshipment Assurance — if your parcel does not arrive within 20 business days we re-ship at no cost (subject to policy terms).
- Loyalty points — 1 point per
Frequently Asked Questions spent (excludes peptides); 100 points = off.
Frequently Asked Questions
Daily then weekly — why the change?
First-week loading establishes drug levels in the nail. From week 3 the lacquer accumulates a depot in the nail plate and weekly application is enough to maintain fungicidal levels. This is also why the weekly polish-remover step matters — clears the built-up film so a fresh application can penetrate.
How long until I can stop?
Depends on response. Toenails: up to 48 weeks of treatment, then assess. Fingernails: typically 6 months. The visible nail may not look fully normal even at the end of treatment — the dead infected portion grows out for months after.
Ciclopirox vs amorolfine — which is better?
Cure rates from topical-only therapy are similar (modest ~30–40%) and both are inferior to oral terbinafine for moderate-to-severe disease. Choose by leaflet preference (daily-then-weekly ciclopirox vs. weekly amorolfine) and patient adherence.
Can I combine with oral terbinafine?
Yes — combination (oral terbinafine 12 weeks + topical ciclopirox 9–12 months) gives higher cure rates than either alone, especially for thick or matrix-involved toenail disease.
Why all the polish-remover faff?
Ciclopirox lacquer is a film-forming polymer. Layers of it build up. Once weekly removal with acetone-based polish remover lets a fresh layer penetrate the underlying nail. Skipping this step makes the next application sit on old polymer rather than soaking into the nail.
Is Nailrox Nail Lacquer the same as Penlac?
Yes — Penlac (in the US) is the original brand. Nailrox Nail Lacquer contains the same active ingredient (ciclopirox 8%), manufactured by Glenmark under WHO-GMP. Bioequivalent.
What if my nail is very thick?
See a podiatrist for nail debridement before starting. Topical lacquer cannot penetrate a 5-mm-thick nail. Combine debridement + oral terbinafine + topical lacquer for the best outcome.
Can I get a pedicure during treatment?
Yes — but use your own files and instruments. Salon files used on infected nails spread fungus to other clients. Disposable single-use files are best.
Why does my nail look worse after a few weeks?
Brittleness and surface roughness are common during treatment; the drug disrupts the nail surface as it penetrates. Continue the schedule. As new healthy nail grows in, the appearance improves.
Can I wear cosmetic nail polish over the lacquer?
Generally not advised on top of ciclopirox — most leaflets recommend keeping the medicated lacquer alone. If you want cosmetic polish for an occasion, remove the medicated film, apply cosmetic polish for the day, then remove and re-start the schedule.
Storage
Store the bottle tightly capped at 15–25 °C, away from heat and flames (the solvent is flammable). Keep out of reach of children. Do not use after expiry.
Other Antifungal Medications you may be interested in
If Nailrox Nail Lacquer is unavailable, here are alternatives.
- Zimig (terbinafine 250 mg) — Oral first-line for dermatophyte onychomycosis; higher cure rate.
- Sporanox (itraconazole 100 mg) — Pulse therapy for onychomycosis alternative.
- Loceryl (amorolfine 5% lacquer) — Different topical lacquer (morpholine), weekly application.
- Nailrox (ciclopirox 8% lacquer) — Different topical lacquer (hydroxypyridinone).
- Keto Cream (ketoconazole 2%) — For coexisting tinea pedis.
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| Strength | 8% w/v 5ml |
|---|---|
| Quantity | 1 Bottle/s, 2 Bottle/s, 3 Bottle/s, 6 Bottle/s |
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Nailrox Nail Lacquer
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