Valgan
Valgan (Valganciclovir 450 mg) — Cipla ganciclovir prodrug for CMV retinitis in HIV/AIDS and CMV prevention/treatment in solid-organ and bone-marrow transplant recipients.
✓ Verificat medical de Morgan Ellis — Cercetător farmaceutic · 8 ani de experiență · Ultima recenzie: mai 2026
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Valgan — valganciclovir 450 mg (Cipla). Ganciclovir prodrug — used for cytomegalovirus (CMV) retinitis in HIV/AIDS, CMV prophylaxis and treatment in solid-organ and bone-marrow transplant recipients, and congenital CMV. Better oral bioavailability than ganciclovir.
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Valgan ships from a WHO-GMP certified manufacturer in plain packaging, billed through a regulated payment processor (the statement descriptor reads a regulated card-payment processor — never MedsBase or any medication name). Every order carries our 20-business-day Reshipment Assurance.
Valganciclovir carries multiple black-box warnings: bone marrow suppression (granulocytopenia, anaemia, thrombocytopenia), animal carcinogenicity and teratogenicity, and male/female fertility impairment. Use only when clearly indicated. Pregnant or potentially pregnant women must use effective contraception during treatment AND for at least 1 month after.
Weekly FBC during induction therapy and the first month of maintenance, then every 2-4 weeks. Stop if neutrophils <500/μL, platelets <25,000/μL, or haemoglobin drops sharply. Monitor renal function (CrCl-based dose adjustment). Monitor visual function during CMV retinitis treatment.
Dosing
| Indicație | Doza |
|---|---|
| CMV retinitis induction (HIV) | 900 mg BID × 21 days with food |
| CMV retinitis maintenance | 900 mg once daily with food |
| CMV prevention (transplant) | 900 mg once daily × 100-200 days post-transplant |
| Congenital CMV (paediatric) | 16 mg/kg BID × 6 months — specialist supervised |
Take with food. Renal-dose adjustment for CrCl <60 mL/min. Tablets must be swallowed whole — handling broken tablets is a teratogenic exposure risk.
Întrebări frecvente
When is valganciclovir indicated?
CMV retinitis in HIV/AIDS (mostly historical with modern ART), CMV prevention and treatment in solid-organ and bone-marrow transplant, congenital CMV in symptomatic neonates. Discuss with infectious disease or transplant specialist.
Cum funcționează?
Prodrug of ganciclovir, converted to active form intracellularly by viral kinases (preferentially in CMV-infected cells). Active form is incorporated into viral DNA as a chain terminator.
Why is monitoring required?
Bone marrow suppression is the dose-limiting toxicity. Up to 25-40% of patients develop significant neutropenia or anaemia. Weekly FBC during induction is mandatory. G-CSF (filgrastim) is sometimes used to manage neutropenia without stopping therapy.
Pregnancy?
Strongly contraindicated due to teratogenicity. Effective contraception during treatment and for at least 1 month after for women, 90 days after for men. Pregnancy testing before starting if reproductive potential.
Drug interactions?
Major: zidovudine (additive marrow suppression), trimethoprim-sulfa, mycophenolate (transplant context), didanosine (raised levels). Probenecid reduces clearance. Always disclose all medications including transplant immunosuppression.
Renal function?
Renally cleared — adjust dose by creatinine clearance. CrCl <10 mL/min: avoid; haemodialysis patients require post-dialysis dosing schedule.
Side effects?
Bone marrow suppression (commonest), GI (nausea, vomiting, diarrhoea), headache, insomnia, fever, retinal detachment in CMV retinitis (disease-related, not drug).
Storage?
Below 30°C in original container. Crushed/broken tablets are teratogenic — handle with gloves; pregnant household members should not handle.
Ce fac dacă uit o doză?
Take when you remember unless nearly time for the next dose. Do not double up. Discuss adherence challenges with your transplant or HIV team — alternative anti-CMV agents (foscarnet, cidofovir) exist if oral therapy fails.
Resistance?
CMV resistance can develop with prolonged exposure — UL97 and UL54 mutations confer ganciclovir resistance. Maraviroc/foscarnet/cidofovir are options for resistant disease, all with their own toxicities.
Other Antiviral Medications
- Zimivir — valacyclovir for HSV
- Natclovir — valacyclovir — Natco brand
- Centrex — valacyclovir 500/1000 mg
- X-Vir — entecavir for HBV
- Lamivir HBV — lamivudine for HBV
More options in HIV Medication
Clasificate în funcție de volumul recent de comenzi MedsBase — ce aleg alți clienți în această categorie.
| Concentrație | 450 mg |
|---|---|
| Cantitate | 4 Tablet/s, 16 Tablet/s, 32 Tablet/s |
| Formă farmaceutică | Comprimat/e |
| Producător | Cipla Inc |
| Indicație | Eye infections by Herpes simplex virus |
| Brand generic | Valganciclovir |
Valgan
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