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Flunil

Flunil (Fluoxetine 10/20/40/60 mg) — long-half-life SSRI for depression, OCD, bulimia and PMDD. self-tapering on stop, FDA-approved <18 for MDD.

Verificat medical de Morgan Ellis — Cercetător farmaceutic · 8 ani de experiență  · Ultima recenzie: mai 2026

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Flunil (Fluoxetine 10 / 20 / 40 / 60 mg) is a selective serotonin reuptake inhibitor used for depression, anxiety, and related disorders. Long half-life (4–16 days) means slow onset and gentle self-taper.

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De ce să comanzi de la MedsBase

Flunil at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our Politica noastră de Reexpediere Garantată — perioadă de livrare de 20 de zile lucrătoare sau retrimitem fără costuri suplimentare — și se califică pentru programul nostru de loialitate pentru clienți. Livrările sunt disponibile în majoritatea destinațiilor la nivel mondial.

How Flunil works

Flunil is a Fluoxetine-containing SSRI tablet supplied by Intas. Available strengths: 10 / 20 / 40 / 60 mg. Take with or without food, at the same time each day for steady-state plasma levels.

SSRIs block the reuptake of serotonin (5-HT) at the presynaptic serotonin transporter (SERT), increasing synaptic serotonin availability. The therapeutic effect lags transporter blockade by 2–6 weeks — the delay reflects downstream adaptations in 5-HT autoreceptor sensitivity, BDNF expression, and hippocampal neurogenesis, not direct receptor effects. Patients who feel “nothing” at 2 weeks should not stop early; assess response at 4–6 weeks of an adequate dose.

Of all SSRIs, fluoxetine is the most activating — useful when fatigue and anergic depression are the dominant symptoms, problematic when anxiety and insomnia are dominant. Take in the morning. Adolescent MDD is one of fluoxetine’s strongest evidence bases (TADS trial).

Indicații și dozaj

IndicațieDoza inițialăȚintăNote
Major depression (adult)20 mg OD morning20–60 mg ODMax 80 mg
OCD20 mg OD × 2 wk40–80 mg ODSlow up-titration
Bulimia nervosa20 mg OD × 1 wk60 mg ODMost-used SSRI for BN
PMDD (continuous or luteal)20 mg OD20 mg ODCycles 1–14 only if luteal
Adolescent MDD (≥8 y)10 mg OD × 1 wk20 mg ODFDA-approved <18

Considerații importante de siguranță

Long half-life — slow on, slow off

Fluoxetine + active metabolite norfluoxetine have a combined elimination half-life of 4–16 days. This means: (1) discontinuation syndrome is rare even on abrupt stop — the drug self-tapers; (2) dose increases take 4–6 weeks to reach steady state; (3) when switching to another antidepressant, allow a 5-week washout before starting an MAOI to avoid serotonin syndrome.

Avertisment cutie neagră privind riscul de suicid (sub 25 de ani)

All SSRIs carry an FDA black-box warning for increased suicidal ideation in patients under 25, particularly in the first 4 weeks and at dose changes. This does primește, mean SSRIs are net-harmful in young people — meta-analyses show net benefit — but it does mean close clinical monitoring during initiation and titration in adolescents and young adults.

Serotonin syndrome

Combining Flunil with other serotonergic agents can cause serotonin syndrome (tremor, hyperreflexia, clonus, hyperthermia, agitation). Avoid concurrent: MAOIs (14-day washout each direction; fluoxetine needs 5 weeks), tramadol, pethidine, dextromethorphan, linezolid, methylene blue, St John’s wort, MDMA. Triptan + SSRI is generally tolerated for migraine — the absolute risk is low.

Efecte secundare frecvente

  • First 1–2 weeks: nausea, headache, jitteriness/anxiety surge, insomnia or somnolence, loose stools — usually self-limit.
  • Persistent: sexual dysfunction (decreased libido, delayed orgasm/anorgasmia, erectile difficulty — affects up to 50% of men and women on SSRIs; the most common reason for discontinuation), weight changes (modest gain over 6–12 months), bruxism, dry mouth, sweating.
  • Rar dar important: hyponatraemia (SIADH, especially in older adults — check Na⁺ at 2 and 4 weeks if at risk), bleeding (additive with NSAIDs/anticoagulants — consider PPI cover), bone-density loss with long-term use.

Interacțiuni medicamentoase

Beyond the sub-specific interactions above:

  • NSAIDs / aspirin / anticoagulants — additive bleeding risk; use a PPI for older adults on chronic NSAID + SSRI.
  • Alte medicamente care prelungesc intervalul QT (amiodarone, sotalol, methadone, ondansetron, haloperidol, ziprasidone) — additive risk.
  • Litiu — increased serotonin signal; monitor for serotonin syndrome and lithium toxicity.
  • CNS depressants (alcohol, benzodiazepines, opioids) — additive sedation.

Sarcina, alăptare, pediatric

Most SSRIs are categoria C in pregnancy with an acceptable risk-benefit profile when depression itself poses real harm. Paroxetine is the exception — first-trimester exposure linked to small absolute increases in cardiac malformations. Sertraline is generally regarded as the SSRI of choice in pregnancy and lactation. Late-third-trimester SSRI exposure can produce a transient neonatal adaptation syndrome (jitteriness, feeding difficulty) that typically resolves within 1–2 weeks. Discuss any change in pregnancy with the prescriber — abruptly stopping during pregnancy carries its own risk (relapse).

Depozitare

Store at 15–30 °C in a dry place, away from direct sunlight and out of reach of children.

Întrebări frecvente

How long until Flunil works?

Some patients notice early effects on sleep and anxiety within 1–2 weeks, but the full antidepressant or anti-anxiety effect typically takes 4–6 weeks at an adequate dose. Don’t conclude Flunil isn’t working until you’ve had at least 4 weeks at a therapeutic dose.

Can I drink alcohol on Flunil?

Alcohol does not chemically interact with SSRIs in a dangerous way at moderate consumption, but it worsens the underlying depression and amplifies SSRI sedation. Many psychiatrists advise minimising alcohol during the first 4–8 weeks while the effect is being established.

Will Flunil change my personality?

No. Adequately-treated patients describe feeling more like themselves, not less. If you feel emotionally blunted, sexually disconnected, or detached after several weeks, raise this with your prescriber — it can be dose-related or medication-specific and is often manageable.

Ce fac dacă uit o doză?

Take it as soon as you remember the same day. If it’s nearly time for the next dose, skip the missed one. Never double up. With short-half-life SSRIs (paroxetine, fluvoxamine), a missed dose can produce mild withdrawal — take it as soon as you remember.

Can I stop Flunil when I feel better?

No — stopping after 4–6 weeks of feeling better is the most common cause of relapse. Most guidelines recommend continuing an effective antidepressant for at least 6–12 months after full remission of the first episode, longer for recurrent depression or anxiety. Always taper rather than stopping abruptly.

Does Flunil cause weight gain?

Most SSRIs cause modest weight gain over 6–12 months (often 2–4 kg). Fluoxetine is the most weight-neutral or even mildly weight-reducing of the SSRIs in some studies. If weight gain is a major concern, this is worth discussing with the prescriber when choosing or switching.

Can Flunil be combined with therapy?

Combination of an SSRI plus structured psychotherapy (CBT for depression and anxiety; ERP for OCD) consistently outperforms either alone in moderate-to-severe disease. Medication addresses biological dysregulation; therapy addresses cognitive and behavioural patterns.

How do I taper Flunil?

For most SSRIs, taper over 4–8 weeks by halving the dose every 2 weeks. Paroxetine and fluvoxamine require slower tapers (often 8–12 weeks) because of their short half-lives. Some patients need hyperbolic tapering (10% reductions every 2–4 weeks) at the bottom end. The prescriber should plan this with you.

Is Flunil addictive?

SSRIs are not addictive in the substance-use-disorder sense — there’s no euphoric effect, no compulsive use, and no escalating tolerance. They do produce physical dependence: abrupt cessation causes withdrawal (discontinuation syndrome). That dependence is not addiction; it is a predictable pharmacological adaptation that resolves with proper taper.

What if I want to switch antidepressants?

Most SSRI-to-SSRI switches use a direct cross-taper or short washout. Switching to or from an MAOI requires a strict washout (14 days; 5 weeks if coming off fluoxetine because of its long half-life) to avoid serotonin syndrome. Switching is a clinician-supervised decision.

Alte Medicamente pentru Sănătatea Mintală

Notă medicală. Această pagină are scop educațional și nu înlocuiește sfatul medical personalizat. Farmacoterapia pentru sănătatea mintală ar trebui inițiată, monitorizată și ajustată de către un clinician calificat. Dacă tu sau cineva cunoscut se află într-o criză suicidală, contactează imediat serviciile de urgență locale sau sună la linia de prevenție a suicidului din țara ta (SUA/Canada: 988; UK: Samaritans 116 123; listă internațională: findahelpline.com).

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Concentrație

10 mg, 20 mg, 40 mg

Cantitate

30 Comprimat/e, 60 Comprimat/e, 90 Comprimat/e, 180 Comprimat/e

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