Reglan

📦 Fiecare comandă este acoperită de politica noastră de Politica noastră de Reexpediere Garantată — dacă coletul dumneavoastră nu sosește în 20 de zile lucrătoare, îl relivrăm.

De ce să comanzi de la MedsBase

Medicamentele noastre generice sunt procurate de la producători certificați WHO-GMP și expediate la nivel mondial în ambalaje discrete și simple — fără denumirea medicamentului pe exteriorul coletului. Plățile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de plăți cu card reglementat — niciodată “MedsBase” sau numele vreunui medicament). Acceptăm și criptomonede și transferuri bancare SEPA. Fiecare comandă este susținută de Politica noastră de Asigurare pentru Relivrare.

De ce să comanzi de la MedsBase

Reglan is supplied from a producător certificat WHO-GMP. Every order ships discreetly worldwide and is covered by our Politica noastră de Reexpediere Garantată — if it does not arrive within 20 business days, we reship at no cost. Metoclopramide remains a first-line agent for several niche indications (migraine-associated nausea, post-operative ileus prevention, lactation enhancement) where its central D2 effect is helpful.

Mecanism de acțiune

Metoclopramide blocks dopamine D2 receptors centrally (in the chemoreceptor trigger zone, the nigrostriatum, and the tuberoinfundibular system) and peripherally (gut). At higher doses it also blocks 5-HT3 and stimulates 5-HT4 receptors in the gut, which contributes to its prokinetic effect. CNS penetration distinguishes it from domperidone and explains both its higher antiemetic potency and its extrapyramidal side-effect profile.

Indicații

• Nausea and vomiting (chemotherapy-induced, post-operative, migraine-associated)
• Diabetic and idiopathic gastroparesis (12-week max under EMA)
• Aspiration prevention pre-anaesthesia (rapid-sequence induction adjunct)
• Adjunct in radiology to speed barium transit
• Off-label: galactagogue

Doza

Adults: 10 mg up to three times daily, 30 minutes before meals and at bedtime if needed. Maximum cumulative duration: 5 days for nausea/vomiting (FDA), 12 weeks for gastroparesis (EMA, specialist). CrCl < 60: reduce dose 50 percent. Hepatic impairment: reduce dose. Children: avoid < 1 year; restricted use in > 1 year for chemo-induced or post-op nausea, weight-based.

Efecte secundare

• Common: drowsiness, restlessness, fatigue, diarrhoea
• Extrapyramidal: acute dystonia, akathisia, parkinsonism, tardive dyskinesia (BLACK-BOX)
• Hyperprolactinaemia: galactorrhoea, gynaecomastia, menstrual disturbance
• Rare: neuroleptic malignant syndrome, seizures, methaemoglobinaemia (G6PD-deficient infants)
• Cardiac: bradycardia and hypotension after rapid IV push

Interacțiuni medicamentoase

• Anticholinergics, opioids: oppose the prokinetic effect.
• Other dopamine antagonists (haloperidol, risperidone, prochlorperazine): additive extrapyramidal risk — avoid stacking.
• MAO inhibitors: hypertensive crisis — avoid.
• SSRIs, SNRIs: serotonin syndrome (rare).
• Levodopa: each blocks the other's effect — do not co-prescribe.
• Digoxin: gastric-emptying acceleration may reduce digoxin absorption.

Întrebări frecvente

How is Reglan different from domperidone?

Both block D2 receptors. Metoclopramide crosses the blood-brain barrier and is more potent as an antiemetic but causes extrapyramidal side effects (FDA black-box). Domperidone is peripheral-only with minimal EPS but has a QT-prolongation signal.

What does the FDA black-box mean for me?

Use the lowest dose for the shortest time. Tell the prescriber immediately about any involuntary tongue, jaw, lip, or limb movements — these may be early tardive dyskinesia and the drug must be stopped.

Can I take it for travel sickness?

There are better-tolerated alternatives (cinnarizine, hyoscine, antihistamines). Metoclopramide is not first-line for motion sickness because it does not act on the vestibular system.

Is it safe in pregnancy?

Category B in the US. Used in pregnancy for nausea/vomiting and is the second-line after pyridoxine-doxylamine when first-line fails. Discuss with obstetric prescriber.

Can I drive on this?

Drowsiness is common, especially in the first few days. Do not drive or operate machinery until you know how it affects you.

What if I develop a stiff neck or strange jaw movements?

Stop the drug and seek medical help. Acute dystonia is treated with IV anticholinergic (procyclidine or benztropine) and is fully reversible.

Why do I have leaky breasts on this medication?

Metoclopramide raises prolactin via pituitary D2 blockade. The effect is reversible on discontinuation.

Can it interact with my Parkinson’s drugs?

Yes — metoclopramide blocks central D2 receptors and can dramatically worsen Parkinson’s motor symptoms. Avoid in Parkinson’s disease.

Depozitare

Below 25°C in a dry place. Keep out of reach of children.

Ce fac dacă uit o doză?

Take it before the next meal, then continue. Do not double up.

Other Gastro Health Medications

• Dompewal — Domperidone (peripheral D2 antagonist)
• Stemetil — Prochlorperazine (antiemetic)
• Doxinate — Doxylamine + B6 (NVP first-line)
• Omez D — Omeprazole + Domperidone SR
• GR8-OD — Pantoprazole + Domperidone SR
• Browse all Gastro Health Medications

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