Stemetil
⚡ Quick Answer — What is Stemetil?
Stemetil is prochlorperazine maleate 5 mg — a phenothiazine first-generation antipsychotic widely used at low doses for severe nausea and vomiting, vertigo, Meniere’s disease, and the labyrinthine vertigo of inner-ear dysfunction. It blocks central D2 dopamine receptors in the chemoreceptor trigger zone (antiemetic) and in the labyrinth (anti-vertigo), and to a lesser extent histamine H1 and muscarinic receptors. Standard dose: 5–10 mg three times daily orally for nausea or vertigo, max 30 mg/day; bipolar/schizophrenia at higher doses is rarely used today given atypical antipsychotic alternatives. WHO-GMP certified manufacturer.
📦 Fiecare comandă este acoperită de politica noastră de Politica noastră de Reexpediere Garantată — dacă coletul dumneavoastră nu sosește în 20 de zile lucrătoare, îl relivrăm.
De ce să comanzi de la MedsBase
Medicamentele noastre generice sunt procurate de la producători certificați WHO-GMP și expediate la nivel mondial în ambalaje discrete și simple — fără denumirea medicamentului pe exteriorul coletului. Plățile cu cardul sunt procesate printr-un procesor reglementat (descrierile de pe extrasul de cont includ un procesor de plăți cu card reglementat — niciodată “MedsBase” sau numele vreunui medicament). Acceptăm și criptomonede și transferuri bancare SEPA. Fiecare comandă este susținută de Politica noastră de Asigurare pentru Relivrare.
De ce să comanzi de la MedsBase
Stemetil is supplied from a producător certificat WHO-GMP. Every order ships discreetly worldwide and is covered by our Politica noastră de Reexpediere Garantată — if it does not arrive within 20 business days, we reship at no cost. Stemetil is a long-established antiemetic and vestibular suppressant used worldwide for severe nausea, vertigo, and Meniere's symptom flares.
Mechanism
Prochlorperazine antagonises central D2 dopamine receptors. In the chemoreceptor trigger zone this produces a strong antiemetic effect (more potent than metoclopramide for severe vomiting). In the inner ear and brainstem vestibular nuclei it suppresses vertigo. H1 antagonism explains the sedation; muscarinic antagonism explains dry mouth. At higher doses it has the typical FGA pharmacology (positive-symptom psychosis suppression).
Indicații
- Severe nausea and vomiting (chemo, post-op, migraine, gastroenteritis)
- Vertigo (vestibular neuronitis, BPPV with severe symptoms, Meniere's flare)
- Meniere’s disease symptom relief (combined with diuretic / dietary salt restriction)
- Labyrinthitis
- Schizophrenia (rarely — superseded by atypicals)
Doza
Adults: 5–10 mg three times daily orally for nausea/vertigo. Acute migraine-associated nausea: 5–10 mg single dose. Meniere’s: 5 mg three times daily, titrate to symptom control (max 30 mg/day). Children: avoid < 10 kg. Hepatic impairment: reduce dose. Elderly: start at half-dose — very high EPS risk.
Efecte secundare
- Common: drowsiness, dry mouth, constipation, blurred vision, postural hypotension
- Extrapyramidal: acute dystonia (oculogyric crisis, torticollis), akathisia, parkinsonism, tardive dyskinesia
- Hyperprolactinaemia: galactorrhoea, menstrual changes
- QT prolongation, torsades de pointes (rare)
- Photosensitivity skin rash, cholestatic jaundice (idiosyncratic)
- Neuroleptic malignant syndrome (rare, life-threatening)
Interacțiuni medicamentoase
- Other dopamine antagonists (metoclopramide, haloperidol, atypicals): additive EPS — avoid stacking.
- QT-prolonging drugs (azithromycin, fluoroquinolones, ondansetron, citalopram, methadone): avoid combination.
- CNS depressants (alcohol, opioids, benzodiazepines): additive sedation, hypotension.
- Levodopa, dopamine agonists: each blocks the other's effect — avoid in Parkinson’s.
- Anticholinergics: additive dry mouth, urinary retention, constipation.
Întrebări frecvente
What is Stemetil mainly used for?
Severe nausea, vomiting, and vertigo. It is more potent than metoclopramide for severe vomiting and is the standard for vestibular vertigo flares.
How quickly will it work?
Antiemetic effect within 30–60 minutes orally. The IM and rectal routes (5 mg or 25 mg suppositories) act within 30 minutes when the patient cannot keep tablets down.
Is it safe to drive on this?
Drowsiness is common. Do not drive until you know how it affects you. The first 1–2 weeks are usually most sedating.
Can I take it with my migraine medication?
Yes — prochlorperazine is often combined with triptans and analgesics during a migraine attack to control nausea. Avoid with QT-prolonging triptan combinations and tell the prescriber.
Is it the same as metoclopramide?
Both are D2 antagonists. Prochlorperazine is more potent for severe vomiting and is preferred for vertigo. Metoclopramide is more prokinetic. Both share extrapyramidal side-effect risk.
Why am I getting muscle spasms?
Acute dystonia is a recognised early side effect — uncontrolled muscle pulling in the neck, jaw, eyes, or trunk. Stop the drug and seek medical help. Treated with IV anticholinergic (procyclidine).
Can I take it long-term for Meniere’s?
Short-to-medium courses for symptom flares are typical. Long-term use (months) raises tardive dyskinesia risk — specialist ENT/neurology supervision recommended.
Is it safe in pregnancy?
Category C. Sometimes used for severe hyperemesis gravidarum when first-line fails. Discuss with obstetric prescriber.
Depozitare
Below 25°C, away from light. Keep out of reach of children.
Ce fac dacă uit o doză?
Take it as soon as you remember. If close to the next dose, skip it. Do not double up.
Other Gastro Health Medications
- Dompewal — Domperidone
- Reglan — Metoclopramide
- Doxinate — Doxylamine + B6 (NVP-specific)
- Zofer — Ondansetron (5-HT3 antiemetic)
- Stugeron — Cinnarizine (vertigo)
- Browse all Gastro Health Medications
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