Estramustine
Estramustine (140 mg) — combined oestrogen-alkylating agent for hormone-refractory prostate cancer. Largely superseded by abiraterone but retained in palliative settings.
✓ Verificat medical de Morgan Ellis — Cercetător farmaceutic · 8 ani de experiență · Ultima recenzie: mai 2026
Răspuns rapid
Estramustine — Estramustine Phosphate 140 mg (WHO-GMP certified manufacturer). Combined estrogen-nitrogen-mustard alkylating agent — historically used for hormone-refractory prostate cancer. Largely superseded by abiraterone and enzalutamide; remains in palliative settings.
Ce beneficii oferă MedsBase:
- producător certificat WHO-GMP
- Ambalaj discret în plic simplu
- Livrare în toată lumea
- Evaluat de peste 1.400 de clienți (citește recenziile)
📦 Garanția de retransmitere: dacă comanda dvs. nu a ajuns în 20 de zile lucrătoare de la expediere, o retransmitem fără costuri suplimentare. Citește politica.
De ce să comanzi de la MedsBase
Estramustine ships from a WHO-GMP certified manufacturer in plain packaging, billed through a regulated payment processor (the statement descriptor reads a regulated card-payment processor — never MedsBase or any medication name). Every order carries our 20-business-day Reshipment Assurance.
⚠️ Specialist-supervised cancer therapy — this medication is started, monitored, and stopped by an oncologist or haematologist. Dosing depends on tumour type, stage, body surface area, organ function, and concomitant therapy. Self-treatment is not appropriate; the information below is educational and supports informed conversations with your specialist.
Estramustine has a strong oestrogen component — increased risk of DVT, PE, MI, gynaecomastia, fluid retention. Avoid in active CV disease, recent thrombosis, or severe heart failure. Monitor for thromboembolic symptoms.
Întrebări frecvente
When is this used?
Combined estrogen-nitrogen-mustard alkylating agent — historically used for hormone-refractory prostate cancer. Largely superseded by abiraterone and enzalutamide; remains in palliative settings.
Side effects to watch?
Hot flushes, gynaecomastia, fatigue, sexual dysfunction (anti-androgen class effect). Drug-specific monitoring as outlined in the safety boxes above.
Interacțiuni medicamentoase?
Vary by molecule — abiraterone is CYP3A4 substrate; bicalutamide is CYP3A4 substrate. Always disclose all medications. Strong CYP3A4 inhibitors/inducers significantly affect levels.
When should it be stopped?
On disease progression, intolerable toxicity, or successful response with planned treatment break. Always specialist-decided — abrupt cessation can result in transient PSA rise (withdrawal response) which is generally not concerning.
PSA monitoring?
PSA every 1-3 months while on therapy. Rising PSA on castration suggests castration-resistance — may need switch to second-line agents (abiraterone, enzalutamide, docetaxel).
Combined androgen blockade?
LHRH agonist (goserelin, leuprolide) + bicalutamide is a common combination. Maximal androgen blockade has modest survival benefit over LHRH alone.
Bone health?
Long-term androgen deprivation accelerates bone loss. Add a bisphosphonate (zoledronic acid) or denosumab in osteopenia/osteoporosis. Calcium and vitamin D supplementation.
Sarcină?
Anti-androgens are teratogenic — partners must use effective contraception during therapy. Most relevant for younger men with localised disease.
Ce fac dacă uit o doză?
Take when you remember if same day; otherwise skip. Specialist may have specific guidance for missed doses depending on regimen.
Cardiovascular monitoring?
Mandatory for fosfestrol; advised for abiraterone (BP, fluid retention, electrolytes); routine for bicalutamide (occasional CV review).
Other Cancer & Anti-Androgen Therapy
- Calutide — bicalutamide 50 mg — alternative anti-androgen brand
- Xbira — abiraterone 250 mg — CYP17 inhibitor for mCRPC
- Honvan — fosfestrol 120 mg — diethylstilbestrol diphosphate
- Estramustine — estramustine phosphate — alkylator for hormone-refractory disease
- Zoldria — zoledronic acid IV for bone metastases
More options in Anti Cancer Medication
Clasificate în funcție de volumul recent de comenzi MedsBase — ce aleg alți clienți în această categorie.
| Concentrație | 140 mg |
|---|---|
| Cantitate | 30 Capsule/s, 60 Capsule/s, 90 Capsule/s |
| Formă farmaceutică | Capsule |
| Producător | United Biotech |
| Indicație | Anti Cancer |
| Brand generic | Estramustine Phosphate |
Estramustine
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