Ipamorelin

✅ Supports lean muscle
✅ Enhances recovery pathways
✅ Promotes metabolic balance
✅ Improves sleep cycles
✅ Boosts tissue repair

Ipamorelin szintetikus peptidvegyületet tartalmaz.

SKU: N/A Kategória: Peptidek Címke: Ipamorelin

✓ Orvosi ellenőrzés Morgan Ellis — Gyógyszerkutató · 8 év tapasztalat · Utolsó felülvizsgálat: 2026 május

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Quick Answer — What is Ipamorelin?

Ipamorelin is a synthetic pentapeptide growth-hormone secretagogue that binds the ghrelin receptor (GHS-R1a) to trigger pulsatile GH release nélkül raising cortisol or prolactin — a selectivity that distinguishes it from older GHRPs. In research it is frequently stacked with CJC-1295 to amplify GH pulse amplitude. Supplied in 2 mg to 10 mg lyophilized vials for laboratory research use only.

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Specifikáció	Részlet
CAS szám	170851-70-4
Molekuláris képlet	C₃₈H₄₉N₉O₅
Molekulatömeg	711.86 Da
Szekvencia	Aib-His-D-2-Nal-D-Phe-Lys-NH₂
Forma	Liofilizált por (vagy a szállított formában)
Tisztaság	≥99% (HPLC-vel ellenőrizve, COA igény szerint)
Tárolás	Liofilizált: 2–8 °C (hűtőszekrény) munkakészletként; −20 °C hosszú távú tárolásra lezáratlan üvegek esetén. Rekonstituált: 2–8 °C, használat ~30 napon belül. Védjük a fénytől. Ne fagyassza-válassza fel az újraállított oldatot.
Oldhatóság	Baktériumstatikus víz (ajánlott) vagy steril víz rövidebb használatra
Kutatási célra	Csak laboratóriumi kutatási célra. Nem használható humán vagy állatgyógyászati diagnosztikai vagy terápiás célra.

What Is Ipamorelin?

Ipamorelin is a synthetic pentapeptide belonging to the growth-hormone-releasing peptide (GHRP) family. Developed by Novo Nordisk in the 1990s and first characterised by Raun et al. (Eur J Endocrinol, 1998), it is classified as a growth hormone secretagogue — a compound that triggers endogenous GH release by activating the ghrelin receptor (GHS-R1a) on pituitary somatotropes.

Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH₂. Molecular weight approximately 711.9 Da. Unlike earlier GHRPs (GHRP-2, GHRP-6, hexarelin), ipamorelin is remarkable for its clean hormonal selectivity — it releases GH without meaningfully raising cortisol, prolactin, or ACTH. This selectivity is why ipamorelin has become the most-studied GHRP of the 21st century. It is supplied as a high-purity lyophilized powder for reconstitution with bacteriostatic water. Ipamorelin is laboratóriumi kutatási célra szolgál and is not intended for human or veterinary diagnosis or therapy. For mechanism, published research, and stacking protocols, see our Ipamorelin & CJC-1295 research guide.

Mechanism of Action — Selective Ghrelin-Receptor Agonism

Ipamorelin binds the growth hormone secretagogue receptor type 1a (GHS-R1a), the endogenous receptor for ghrelin. The receptor is expressed on pituitary somatotropes and in the hypothalamic arcuate nucleus, and activation triggers a pulsatile release of growth hormone from pituitary storage granules.

Pulsatile GH release — unlike continuous recombinant GH administration, ipamorelin produces a pulsatile GH profile that more closely mimics endogenous nocturnal GH bursts. This pulsatility is important mechanistically because IGF-1 signaling is more responsive to pulsed than continuous GH exposure.
Clean hormonal selectivity — the defining feature of ipamorelin. Older GHRPs (GHRP-2, GHRP-6, hexarelin) also raise cortisol and prolactin, producing off-target effects that complicate research interpretation. Ipamorelin does not, making it the preferred GHRP for research where those confounders matter.
GHRH complementarity — ipamorelin acts via the ghrelin-receptor pathway; GHRH analogs such as CJC-1295 act via a parallel GHRH-receptor pathway. Co-administration produces synergistic GH pulse amplification greater than either peptide alone — the basis of the classic “ipamorelin + CJC-1295” research stack.

Because ipamorelin works through the body’s own pituitary GH supply, it is subject to normal negative-feedback regulation by somatostatin and IGF-1. This auto-regulation is a research-relevant safety feature distinguishing secretagogues from exogenous recombinant GH.

Közzétett kutatási alkalmazások

Ipamorelin is used in laboratory research contexts that investigate:

GH pulse research — pulsatile growth-hormone release kinetics and IGF-1 response in rodent models (Raun et al., Eur J Endocrinol 1998)
Skeletal muscle recovery — post-injury and post-exercise recovery, often stacked with BPC-157 és TB-500
Body composition research — lean-mass preservation and fat-mass research, often in caloric-deficit or disuse-atrophy models
Sleep research — slow-wave sleep and nocturnal GH-surge research; pre-sleep dosing is the typical research timing
Bone density research — osteoblast activity and bone mineral density via GH/IGF-1 axis modulation
CJC-1295 stacking research — synergistic GH amplification protocols with GHRH analogs (see the Ipamorelin + CJC-1295 stack guide)

For broader context on the GH-axis peptide landscape, see the research peptides catalog.

Elérhető erősségek és koncentrációk

MedsBase stocks ipamorelin in the following lyophilized vial sizes. Each variation ships in 10-vial, 20-vial, or 30-vial pack formats:

Ampulla erőssége	Tipikus felhasználási terület	Csomagméret
2 mg	Short research protocols, pilot dosing	10, 20, or 30 vials
5 mg	Szabványos kutatási erősség, leggyakrabban rendelt	10, 20, or 30 vials
10 mg	Extended research, lowest per-mg cost	10, 20, or 30 vials

All three strengths are the same chemical form (lyophilized powder, 99%+ HPLC purity). A 5 mg vial at 2.5 mg/mL dilution delivers approximately 16 administrations of 300 mcg, matching common research protocols.

How It Compares — Ipamorelin vs CJC-1295

Ipamorelin and CJC-1295 with DAC are the two most-studied GH-axis peptides. They are near-universally co-administered rather than substituted, because they act on parallel receptor systems that produce synergy together:

Kritérium	Ipamorelin	CJC-1295 with DAC
Peptide class	GHRP (growth-hormone-releasing peptide)	GHRH analog (growth-hormone-releasing hormone)
Receptor	GHS-R1a (ghrelin receptor)	GHRH receptor on somatotropes
Effect on GH	Pulsatile burst release	Sustained baseline elevation
Felezési idő	~2 hours	~7 days (albumin-bound)
Adagolás	200–300 mcg, 2–3x daily	1–2 mg weekly
Stacking	Canonical pairing with CJC-1295	Canonical pairing with ipamorelin

The full stacking rationale, dose-timing, and synergy-mechanism analysis are in our Ipamorelin and CJC-1295 stack research guide.

Tárolás és rekonstitúció

Rekonstitúció előtt: store lyophilized vials refrigerated at 2–8 °C in original packaging, stable up to 36 months. Avoid freeze-thaw cycles on the powder.

Rekonstitúciós eljárás: inject bacteriostatic water down the side wall of the peptide vial per the chart above. Swirl gently — do nem shake — and allow 5–10 minutes for full dissolution. A correctly reconstituted solution should be clear and colourless.

Rekonstitúció után: store refrigerated at 2–8 °C and use within 30 days. Do not freeze reconstituted solution — freeze-thaw cycles degrade peptide integrity.

Gyakran Ismételt Kérdések

What is ipamorelin used for in research?

Ipamorelin is used in laboratory research investigating pulsatile growth hormone release, IGF-1 axis signaling, skeletal muscle recovery, body composition, sleep research, bone density, and GH-axis stacking with GHRH analogs. It is nem FDA-approved and is sold here strictly for laboratory research use only.

What is the typical ipamorelin research dose?

Published preclinical protocols typically use 200–300 mcg per administration, 2–3 times daily, often with one dose timed pre-sleep to align with nocturnal GH-surge research. A 5 mg vial reconstituted with 2.0 mL bacteriostatic water yields 2.5 mg/mL — 12 ticks on a U-100 syringe delivers 300 mcg.

How is ipamorelin different from CJC-1295?

Ipamorelin is a GHRP (growth-hormone-releasing peptide) that binds the ghrelin receptor for pulsatile GH release. CJC-1295 is a GHRH (growth-hormone-releasing hormone) analog that binds a different receptor on the same pituitary cells for sustained GH elevation. The two are typically stacked because their mechanisms are additive/synergistic.

Is ipamorelin FDA approved?

No. Ipamorelin is not approved by the FDA, EMA, MHRA, or any other regulator for human therapeutic use. It has been studied in early-phase human clinical trials but never advanced to approval. All ipamorelin sold by research-use-only suppliers is for laboratory investigation only.

Why is ipamorelin preferred over older GHRPs like GHRP-6?

Ipamorelin’s defining feature is clean hormonal selectivity — it releases GH without raising cortisol, prolactin, or ACTH. Older GHRPs (GHRP-2, GHRP-6, hexarelin) raise all three, producing off-target effects that complicate research interpretation and produce unwanted side effects. This selectivity has made ipamorelin the most-studied GHRP of the past two decades.

How should ipamorelin be stored?

Liofilizált ampullák: 2–8 °C-on hűtve, eredeti csomagolásban, akár 36 hónapig stabil. Rekonstituált oldat: 2–8 °C-on hűtve, 30 napon belül használja fel. Ne fagyassza a rekonstituált oldatot – a fagyasztás-olvadás ciklusok károsítják a peptidet.

How do I reconstitute ipamorelin?

Follow the reconstitution chart above. Add bacteriostatic water down the side wall of the vial, swirl gently, and allow 5–10 minutes for full dissolution. Do nem shake the vial.

Can ipamorelin and CJC-1295 be stacked in research?

Yes. The ipamorelin + CJC-1295 combination is the canonical GH-axis research stack. The two peptides act on parallel receptor systems (ghrelin vs GHRH receptor) and their effects on GH release are synergistic — combined use produces larger GH pulses than either alone. See our stack guide.

Milyen erősségű készítményeket tart készleten a MedsBase?

MedsBase carries ipamorelin in 2 mg, 5 mg, and 10 mg lyophilized vials. Each strength is available in 10-vial, 20-vial, or 30-vial pack sizes. All vials are supplied at 99%+ HPLC purity with a certificate of analysis on request.

Does ipamorelin cause side effects in research?

Ipamorelin has been reported with a clean safety profile at typical research doses. Its selective receptor binding avoids the cortisol and prolactin elevation seen with older GHRPs. Long-term human safety data are not available because human trials were not completed.

Why is pre-sleep timing used in ipamorelin research?

Endogenous growth-hormone release is naturally pulsatile and strongest during slow-wave sleep. Research protocols typically time one ipamorelin dose 30–60 minutes before sleep to amplify the natural nocturnal GH surge rather than compete with daytime somatostatin tone.

What is the half-life of Ipamorelin?

Ipamorelin has a short plasma half-life of approximately 2 hours in preclinical research, consistent with the broader GHRP peptide class. This rapid clearance underpins the pulsatile, multiple-daily dosing schedules most commonly used in ipamorelin research protocols.

How does Ipamorelin compare to GHRP-6 in research?

Ipamorelin is highly selective for the GHSR-1a receptor and does not significantly elevate cortisol or prolactin in preclinical studies — a key distinction from GHRP-6, which activates ghrelin receptors more broadly and is associated with transient cortisol and prolactin increases. This selectivity is a primary reason ipamorelin is frequently preferred in published GH-secretagogue research.

Can I order ipamorelin for international shipping?

Yes. MedsBase ships ipamorelin worldwide from our dedicated peptide shipping network. Peptide-only orders qualify for our standalone peptide shipping service. Orders ship in temperature-controlled packaging with full tracking.

If your recovery protocol pairs ipamorelin’s GH-pulse stimulation with direct tissue-repair peptides for tendon or ligament work, our Peptide Healing Stack (BPC-157 5 mg + TB-500 5 mg) covers the angiogenesis + cytoskeletal-repair side of the regimen with bacteriostatic water included for reconstitution.

Egyéb peptidok a regeneráció és teljesítmény kutatásához

BPC-157 — Testvédő vegyület — ín, szalag, bél regenerációs kutatás
TB-500 — Thymosin Beta-4 fragmentum — lágy szövetek és érrendszer regenerációs kutatás
CJC-1295 with DAC — GHRH analóg meghosszabbított felezési idővel
GHK-Cu — Rézpeptid — bőr és kötőszövet regenerációs kutatás
IGF-1 LR3 — Long-R3 IGF-1 analog — anabolic / regenerative research

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Olvasd el teljes, bizonyítékokon alapuló útmutatónkat: Ipamorelin & CJC-1295 — mechanism, stacking & protocols. Covers mechanism of action, ghrelin vs GHRH receptor pharmacology, published stacking protocols, reconstitution, dose-timing, and safety notes.