Centrex
Centrex (Valacyclovir 500/1000 mg) — Centurion Lab acyclovir prodrug for HSV management including initial and recurrent genital herpes, cold sores, and herpes zoster.
✓ Verificat medical de Morgan Ellis — Cercetător farmaceutic · 8 ani de experiență · Ultima recenzie: mai 2026
Răspuns rapid
Centrex — valacyclovir 500/1000 mg (Centurion Lab). Acyclovir prodrug — for genital herpes (initial + suppression), herpes labialis (cold sores), herpes zoster (shingles), and prophylaxis of CMV in transplant. Preferred over acyclovir for adherence: better oral bioavailability allows 2-3× daily dosing.
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De ce să comanzi de la MedsBase
Centrex ships from a WHO-GMP certified manufacturer in plain packaging, billed through a regulated payment processor (the statement descriptor reads a regulated card-payment processor — never MedsBase or any medication name). Every order carries our 20-business-day Reshipment Assurance.
Valacyclovir is renally cleared; dehydration causes crystallisation and acute kidney injury. Maintain good fluid intake. Adjust dose for CrCl <50 mL/min. Caution in the elderly.
Dosing by indication
| Indicație | Doza |
|---|---|
| Initial genital herpes (immunocompetent) | 1 g BID × 7-10 days |
| Recurrent genital herpes (start within 24 hours) | 500 mg BID × 3 days OR 1 g once daily × 5 days |
| Suppressive therapy (≥6 episodes/year) | 500 mg or 1 g once daily long-term |
| Cold sores (start at first prodrome) | 2 g BID × 1 day (single-day regimen) |
| Herpes zoster (shingles, <72 hours from rash onset) | 1 g TID × 7 days |
| Prevention of HSV transmission to partner (with safer sex practices) | 500 mg once daily long-term |
Renal dose adjustment is required for CrCl <50 mL/min. Adequate hydration during therapy reduces crystallisation risk.
Întrebări frecvente
Valacyclovir vs acyclovir — which is better?
Same active molecule (acyclovir). Valacyclovir has 3-5× higher oral bioavailability and allows 2-3× daily dosing instead of 5×, dramatically improving adherence. Reserved for severe disease (HSV encephalitis, neonatal HSV), IV acyclovir is still preferred.
When to start treatment?
Within 24 hours of symptom onset for episodic genital herpes. Within 72 hours of rash for shingles. At first prodrome for cold sores. Earlier = shorter outbreak.
How long for suppression?
At least 6-12 months for genital herpes suppression in patients with frequent recurrences. Reassess yearly — the natural history is often improvement over years, so a trial off therapy is reasonable.
Side effects?
Generally well-tolerated: headache, nausea, fatigue, dizziness. Rare: thrombotic thrombocytopenic purpura/haemolytic uraemic syndrome (TTP/HUS) in immunocompromised patients (FDA warning), acute kidney injury (especially if dehydrated).
Pregnancy?
Valacyclovir is widely used in pregnancy (Pregnancy Category B), particularly suppressive therapy from 36 weeks in HSV-positive women to prevent neonatal HSV. Discuss with obstetric team.
Drug interactions?
Few major interactions. Avoid combination with other nephrotoxic drugs (NSAIDs chronic, aminoglycosides). Probenecid + cimetidine modestly raise levels — usually clinically insignificant.
Renal dose adjustment?
Required for CrCl <50 mL/min. Risk of accumulation, neuropsychiatric symptoms (confusion, hallucinations) in renal failure especially in elderly.
Ce fac dacă uit o doză?
Take when you remember unless nearly time for the next dose. Do not double up. Missing doses in episodic therapy reduces effect; in suppression, occasional missed doses are tolerable but consistency matters for transmission prevention.
Will it cure herpes?
No — herpes infection is lifelong. Antivirals reduce viral replication during outbreaks and prevent transmission but do not eradicate latent virus. Newer cure-focused research (CRISPR, gene editing) is experimental.
What about transmission risk?
Suppressive valacyclovir in the HSV-positive partner reduces transmission to the negative partner by ~50% (Corey 2004). Combined with consistent condom use and avoiding sex during outbreaks, transmission risk drops further.
Other Antiviral Medications
- Zimivir — valacyclovir 500/1000 mg — alternative brand
- Natclovir — valacyclovir — Natco brand
- Centrex — valacyclovir 500/1000 mg — Centurion brand
- Valgan — valganciclovir 450 mg — for CMV in transplant
- Zovirax — acyclovir — older alternative
More options in HIV Medication
Clasificate în funcție de volumul recent de comenzi MedsBase — ce aleg alți clienți în această categorie.
| Concentrație | 500 mg, 1000 mg |
|---|---|
| Cantitate | 30 Tablet/s, 60 Tablet/s, 90 Tablet/s, 120 Tablet/s, 360 Tablet/s |
| Pharma Form | Tablet/s |
| Manufacturer | Centurion Lab |
| Treatment | HIV |
| Generic Brand | Valacyclovir |
Centrex
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