Theo-Asthalin
✅ Effective asthma symptom control
✅ Rapid bronchospasm relief
✅ Improved lung function
✅ Enhanced quality of life
Contains Salbutamol and Theophylline
✓ Медицински преглед от Morgan Ellis — Фармацевтичен изследовател · 8 години опит · Последен преглед: май 2026 г.
⚡ Quick Answer — What is Theo-Asthalin?
Theo-Asthalin съдържа theophylline + salbutamol, methylxanthine bronchodilator with anti-inflammatory effects, used as add-on therapy for chronic asthma and COPD. Theophylline acts on multiple targets — phosphodiesterase inhibition (raising cAMP), adenosine receptor antagonism, and HDAC2 activation (anti-inflammatory). It has a narrow therapeutic index (target serum 10–20 mg/L; toxicity at 20+) and many drug interactions, requiring careful dosing and (in some patients) blood-level monitoring. Each tablet contains theophylline 100 mg + salbutamol 2 mg, произведена от Cipla at WHO-GMP certified facilities.
📦 Всяка поръчка е покрита от нашата Политика за повторна изпратка — ако вашата пратка не пристигне в рамките на 20 работни дни, ние я изпращаме отново.
Защо да поръчвате от MedsBase
Нашите генерични лекарства се доставят от производители, сертифицирани от WHO-GMP, и се изпращат по целия свят в дискретна, обикновена опаковка — без име на лекарството външно на пратката. Плащанията с карта се обработват чрез регулиран процесор (описанието на извлечението включва регулиран процесор за плащане с карта — никога “MedsBase” или име на лекарство). Приемат се също криптовалути и банков превод SEPA. Всяка поръчка е подкрепена от нашата политика за гарантирано преизпращане.
What Is Theo-Asthalin?
Theo-Asthalin is an oral methylxanthine bronchodilator. Methylxanthines are derived from natural alkaloids (theophylline is the dimethylxanthine present in tea). Their use has declined since the 1990s as inhaled β2-agonists and corticosteroids became first-line — but they retain a role as third-line add-on therapy in difficult asthma and COPD.
How Does Theo-Asthalin Work?
- Phosphodiesterase inhibition (PDE3, PDE4) — raises cyclic AMP in airway smooth muscle and inflammatory cells; net result is bronchodilation and reduced mediator release.
- Adenosine receptor antagonism — blocks adenosine-mediated bronchoconstriction and mast-cell mediator release.
- HDAC2 activation (theophylline at low serum levels 5–10 mg/L) — restores corticosteroid responsiveness in COPD and severe asthma where steroid resistance is partly mediated by reduced HDAC2.
- Diaphragm contractility — methylxanthines reduce diaphragm fatigue, useful in COPD with severe airflow limitation.
Употреба и показания
- Severe chronic asthma — add-on to high-dose ICS-LABA where additional bronchodilation is needed
- COPD maintenance — add-on to LAMA-LABA or triple therapy
- Nocturnal asthma — sustained-release formulation provides overnight bronchodilation
- Apnoea of prematurity (theophylline) — neonatal use
- Cor pulmonale and pulmonary hypertension — adjunct
Theo-Asthalin Dosage
| Patient | Доза | Честота |
|---|---|---|
| Adults | 1 таблетка | Three to four times daily |
| Children >12 yr | 1 таблетка | Three times daily |
Side Effects of Theo-Asthalin
- Nausea, vomiting, dyspepsia
- Главоболие
- Tremor
- Insomnia, restlessness
- Tachycardia, palpitations
- Mild hypokalaemia at high doses
Toxic levels (>20 mg/L) — emergency:
- Severe nausea, persistent vomiting
- Cardiac arrhythmia (atrial fibrillation, supraventricular tachycardia)
- Seizures (often without warning)
- Hypotension, hyperglycaemia, hypokalaemia, hypercalcaemia
Предупреждения и предпазни мерки
- Narrow therapeutic index. Target serum 10–20 mg/L. Check blood level 5 days after starting, after dose change, with new interacting drug, with smoking cessation, and during illness/fever (clearance falls).
- Many drug interactions — see interactions table. Most metabolised by CYP1A2; many inhibitors and inducers shift levels significantly.
- Smoking induces CYP1A2 and lowers theophylline levels by ~50% — re-titrate at smoking cessation.
- Cardiac disease: use cautiously in arrhythmias, heart failure, severe hypertension.
- Hyperthyroidism: increased clearance plus exaggerated adrenergic effects.
- Бременност и кърмене: generally avoided; use only if benefit clear.
- Liver disease: reduce dose — methylxanthines are hepatically metabolised.
Противопоказания
- Hypersensitivity to theophylline or other xanthines (caffeine, theobromine)
- Активна пептична язва
- Uncontrolled tachyarrhythmias
- Severe heart failure (NYHA IV)
Лекарствени взаимодействия
| Interacting drug | Ефект | Какво да правите |
|---|---|---|
| Ciprofloxacin, erythromycin, clarithromycin, fluvoxamine | Inhibit CYP1A2 → raise theophylline levels → toxicity (nausea, arrhythmia, seizures) | Avoid or reduce theophylline dose 50%; check serum levels |
| Cimetidine, allopurinol | Raise theophylline levels | Reduce dose; monitor levels |
| Phenytoin, carbamazepine, rifampicin | Induce CYP — lower levels | Higher dose may be needed |
| Smoking | Induces CYP1A2 — lower levels | Re-titrate dose at smoking cessation |
| β-agonists, diuretics | Additive hypokalaemia | Monitor potassium |
Съхранение
- Store below 25°C in a cool, dry place away from direct sunlight.
- Keep in original packaging until use to protect from moisture and light.
- Do not use after the expiry date printed on the strip.
- Keep out of reach of children.
Свързани алтернативи в MedsBase
- Asthalin Inhaler — salbutamol reliever
- Budecort Inhaler — budesonide ICS preventer
- Foracort Inhaler — budesonide + formoterol ICS-LABA
- Tiova Inhaler — tiotropium LAMA for COPD
- Montair — montelukast LTRA tablet
Често задавани въпроси
Why combine theophylline with salbutamol?
The combination delivers β2 agonism (bronchodilation) plus methylxanthine effect (additional bronchodilation, anti-inflammatory, diaphragm contractility) in one tablet — historically convenient for compliance.
Is this combination still used?
Less commonly than separate components. Modern practice prefers inhaled therapy (β2 agonist + ICS) over oral combinations, both for safety (lower systemic exposure) and efficacy.
Are the side effects of both drugs additive?
Yes — tremor, tachycardia, headache, insomnia, hypokalaemia are amplified by both components. Monitor cardiovascular tolerance.
How fast does Theo-Asthalin start working?
Salbutamol component begins in 15–30 min; theophylline reaches steady state over days.
Can I take it with my inhaler?
Possibly — discuss with your prescriber. Stacking oral and inhaled β2-agonists can increase tremor, tachycardia, and hypokalaemia.
Will it interact with my heart medications?
Theophylline interacts with many drugs (see interaction table). Always tell your doctor what you are taking.
Is it safe in pregnancy?
Generally avoided; inhaled therapy is preferred.
How long does each tablet last?
Both components last 4–6 hours; dosing 3–4 times daily.
Can I crush the tablet?
Standard tablets can be crushed; controlled-release versions cannot. Check the label.
Свързани алтернативи
Други продукти в Хронични заболявания които клиентите също разглеждат:
More options in Asthma/COPD Treatment
Класирани според скорошния обем на поръчки в MedsBase — какво избират други клиенти в тази категория.
| Сила | 2mg + 100mg, 4mg + 200mg |
|---|---|
| Количество | 30 Таблетки, 60 Таблетки, 90 Таблетки |
| Фармацевтична форма | Таблетки |
| Производител | Cipla Inc |
| Лечение | Asthma |
Theo-Asthalin
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Theo-Asthalin
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