Careprost Plus Bimatoprost Eye Drops

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What is Careprost Plus Eye Drops?

Careprost Plus Eye Drops is a fixed-dose combination eye drop manufactured by Sun Pharma, containing bimatoprost 0.03% (prostaglandin F2α analog) and timolol maleate 0.5% (non-selective beta-blocker). The 3 mL bottle delivers two complementary IOP-lowering mechanisms in a single drop, simplifying twice-daily prostaglandin + beta-blocker regimens to once-daily dosing. Used when single-agent therapy fails to reach target IOP.

How It Works

The combination targets both sides of the IOP equation: bimatoprost increases aqueous humour outflow through the uveoscleral pathway via FP-receptor activation, while timolol reduces aqueous humour production at the ciliary epithelium by blocking beta-1 and beta-2 adrenergic receptors. The dual mechanism delivers ~30–35% IOP reduction — slightly greater than monotherapy with either component.

Indications

• Open-angle glaucoma not adequately controlled on a single IOP-lowering agent
• Ocular hypertension where target IOP requires more than monotherapy
• Step-up from monotherapy to combination therapy without adding a second bottle (improves adherence)

Dosing

One drop in the affected eye(s) once daily, in the evening. Wait at least 5 minutes if using other eye drops. Remove contact lenses before instillation; reinsert after 15 minutes. Press the inner corner of your eye (punctal occlusion) for 1–2 minutes after each drop to reduce systemic absorption of timolol.

Side Effects

Eye: conjunctival hyperaemia (10–25%), iris pigmentation (permanent in light eyes), eyelash thickening / lengthening, periorbital fat atrophy, stinging, dry eye, blurred vision.

Systemic (from timolol absorption): bradycardia, hypotension, bronchospasm, fatigue, depression, decreased libido, masking of hypoglycaemia signs in diabetics.

Warnings & Contraindications

• Asthma, severe COPD — absolute contraindications
• Sinus bradycardia (HR < 50), second/third-degree AV block, cardiogenic shock
• Overt heart failure
• Active uveitis, herpetic keratitis, pseudophakia with macular oedema risk
• Pregnancy Category C — avoid; switch monotherapy under specialist guidance
• Drug interactions — additive with oral beta-blockers, calcium-channel blockers (diltiazem/verapamil), and digoxin

Storage

Store at 2–25°C, protected from light. Discard 28 days after first opening.

Frequently Asked Questions

When should I use Careprost Plus Eye Drops?

Once daily in the evening. Combination therapy delivers more IOP reduction than either component alone, but only when monotherapy is inadequate.

Can I use Careprost Plus Eye Drops if I have asthma?

No. The timolol component can cause bronchospasm even when applied to the eye — significant systemic absorption occurs through the nasolacrimal duct. Asthma is an absolute contraindication.

What is punctal occlusion and why does it matter?

After instilling the drop, gently press the inner corner of your eye (where it meets the nose) for 1–2 minutes. This blocks drainage into the nasolacrimal duct and reduces systemic timolol absorption by ~70%, lowering the risk of bradycardia, fatigue, and bronchospasm.

How does Careprost Plus Eye Drops compare with separate bottles?

Same mechanism, simpler regimen. Adherence improves significantly when the combination drop replaces two separate bottles taken at different times.

Will my eye colour change?

Yes — possibly. Bimatoprost can permanently darken light-coloured irises (blue, green, hazel). Brown irises are typically unaffected. Discuss with your ophthalmologist before starting.

Can I drive after using Careprost Plus Eye Drops?

There may be transient blurred vision for 5–10 minutes after instillation. Wait until vision clears before driving.

Is Careprost Plus Eye Drops safe with my heart medications?

Tell your prescriber if you take oral beta-blockers (atenolol, metoprolol, propranolol), calcium-channel blockers (diltiazem, verapamil), or digoxin. Additive bradycardia and AV-block effects are possible.

What happens if I miss a dose?

Skip it and resume normal evening schedule next day. Do not double dose — efficacy does not increase with extra drops.

Can I use Careprost Plus Eye Drops during pregnancy?

Category C. Avoid in pregnancy and breastfeeding unless an ophthalmologist judges the benefit outweighs the risk. Switch to a monotherapy with a better safety profile.

How quickly does Careprost Plus Eye Drops work?

IOP reduction starts within hours; steady-state effect at 4 weeks. Maximum reduction ~30–35% from baseline.

Other Eye-Care Medications

Customers viewing this product also consider these alternatives in our Eye Care range:

• Xalatan Eye Drop (latanoprost)
• Azopt Eye Drops (brinzolamide)
• Alphagan P Drop (brimonidine)
• Iotim Eye Drops (timolol)
• Careprost (bimatoprost)

Medical Disclaimer

The information on this page is for educational purposes only and is not a substitute for medical advice from a qualified ophthalmologist or optometrist. Eye conditions can rapidly threaten sight — sudden vision loss, severe pain, or trauma is an ophthalmology emergency. Always consult an eye-care professional before starting, stopping, or changing any treatment.

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