Dorzox Eye Drop

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What is Dorzox Eye Drop?

Dorzox Eye Drop is manufactured by Cipla and contains Dorzolamide HCl 2% as a sterile ophthalmic clear solution. It is a topical carbonic anhydrase inhibitor used to lower IOP in glaucoma. Dorzolamide is a clear solution. Some patients report a transient bitter taste from drainage into the throat, and mild stinging from the acidic pH (pH 5.6).

How It Works

Dorzolamide HCl blocks carbonic anhydrase isoenzyme II in the ciliary epithelium, slowing the formation of bicarbonate and the consequent flow of sodium and water into the posterior chamber. The result is reduced aqueous humour production and lower IOP. Topical CAIs reach significant intraocular concentration without the systemic side effects of oral acetazolamide (paraesthesia, kidney stones, taste disturbance).

Indications & Dosing

Side Effects

Local: blurred vision (less common), stinging on instillation (common, especially with dorzolamide), bitter taste in mouth (drainage through nasolacrimal duct), conjunctival hyperaemia, ocular pruritus, eyelid reactions.

Systemic: headache, fatigue (rare), kidney stones (very rare with topical use, in contrast to oral acetazolamide).

Warnings & Contraindications

• Severe sulfonamide hypersensitivity
• Severe renal impairment (CrCl < 30 mL/min) — accumulation possible
• Severe hepatic impairment
• Concurrent oral CAIs (acetazolamide, methazolamide) — additive but limited extra benefit
• Corneal endothelial dysfunction (Fuchs dystrophy, post-corneal-graft) — CAIs may worsen corneal oedema
• Pregnancy Category C — avoid unless benefit outweighs risk

Storage

Store at 15–25°C. Discard 28 days after first opening. Keep tightly capped between uses.

Frequently Asked Questions

What is the difference between Dorzolamide HCl and acetazolamide?

Both target the same enzyme. Topical Dorzolamide HCl delivers therapeutic levels at the eye with minimal systemic exposure. Oral acetazolamide produces systemic side effects (paraesthesia, taste changes, kidney stones, metabolic acidosis) that often limit long-term use.

Can I use Dorzox Eye Drop if I'm allergic to sulfa antibiotics?

If you had Stevens-Johnson syndrome or anaphylaxis to a sulfonamide, avoid topical CAIs. Mild rash with sulfamethoxazole is not an absolute contraindication, but discuss with your ophthalmologist before starting.

Why does Dorzox Eye Drop make my mouth taste bitter?

After instillation, the drop drains through the nasolacrimal duct into the throat. Dorzolamide has a recognisable bitter taste. Punctal occlusion (pressing the inner corner of your eye for 1–2 minutes) reduces the effect.

How quickly does Dorzox Eye Drop work?

IOP reduction begins within 1 hour of the first dose; steady-state effect at 1–2 weeks. Average reduction is 18–22% from baseline as monotherapy.

Is the blurred vision after instilling Dorzox Eye Drop normal?

Mild transient blur lasting a few minutes is common as the drop spreads across the cornea. If blur persists beyond 10–15 minutes, contact your eye-care professional.

Can I combine Dorzox Eye Drop with other glaucoma drops?

Yes — CAIs are additive with beta-blockers, prostaglandin analogs, and alpha-2 agonists. Wait 5 minutes between different bottles. Fixed combinations such as dorzolamide+timolol exist for adherence.

What if I forget a dose?

Take it as soon as you remember unless the next scheduled dose is close — then skip the missed one. Do not double up.

Can I use Dorzox Eye Drop in pregnancy?

Category C. Topical CAIs cross the placenta in small amounts. Avoid unless your ophthalmologist judges the benefit clearly outweighs the risk. Discuss alternatives such as brimonidine or selective laser trabeculoplasty.

Why three times a day instead of twice?

When used as monotherapy, Dorzolamide HCl has an 8-hour duration so three-times-daily dosing maintains 24-hour IOP control. When added to an existing beta-blocker or prostaglandin, twice daily is sufficient because the partner drug provides additional coverage.

What if my eye becomes red or itchy?

Mild conjunctival redness is common in the first 1–2 weeks and usually settles. Persistent redness, swollen lids, or itching may indicate a hypersensitivity reaction — stop the drop and contact your ophthalmologist.

Other Eye-Care Medications

Customers viewing this product also consider these alternatives in our Eye Care range:

• Xalatan Eye Drop (latanoprost)
• Azopt Eye Drops (brinzolamide)
• Alphagan P Drop (brimonidine)
• Iotim Eye Drops (timolol)
• Careprost (bimatoprost)

Medical Disclaimer

The information on this page is for educational purposes only and is not a substitute for medical advice from a qualified ophthalmologist or optometrist. Eye conditions can rapidly threaten sight — sudden vision loss, severe pain, or trauma is an ophthalmology emergency. Always consult an eye-care professional before starting, stopping, or changing any treatment.

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