Ca Atra
Ca Atra (All-trans Retinoic Acid 10 mg) — Cipla differentiating agent for acute promyelocytic leukaemia (APL). Combined with anthracycline or arsenic trioxide for near-curative response.
✓ Ιατρικά ελεγμένο από Morgan Ellis — Ερευνητής Φαρμακευτικής · 8 χρόνια εμπειρία · Τελευταία αναθεώρηση: Μάιος 2026
Quick Answer
Ca Atra — All-trans Retinoic Acid (Tretinoin) 10 mg (Cipla Inc). Differentiating agent for acute promyelocytic leukaemia (APL) — combined with anthracycline or arsenic trioxide gives near-curative remission rates. Specialist haematology supervision.
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⚠️ Specialist-supervised cancer therapy — this medication is started, monitored, and stopped by an oncologist or haematologist. Dosing depends on tumour type, stage, body surface area, organ function, and concomitant therapy. Self-treatment is not appropriate; the information below is educational and supports informed conversations with your specialist.
Differentiation syndrome (formerly retinoic acid syndrome) — fever, dyspnoea, weight gain, peripheral oedema, hypotension, pleural/pericardial effusion. Occurs days 5-21 of induction. Treat immediately with high-dose dexamethasone. Mortality rate ~10% if unrecognised. Mandatory haematology monitoring.
Συχνές Ερωτήσεις
When is this used?
Differentiating agent for acute promyelocytic leukaemia (APL) — combined with anthracycline or arsenic trioxide gives near-curative remission rates. Specialist haematology supervision. Specific protocols are oncologist-determined.
Side effects?
Class-typical: myelosuppression, nausea, alopecia, mucositis, fatigue. Specific toxicities depend on the drug — see safety boxes above.
Drug interactions?
Cancer chemotherapy has multiple critical interactions. Always disclose all medications including herbals and supplements. Anticoagulants, anticonvulsants, antibiotics, antifungals, and antivirals all need review.
Pregnancy?
Cytotoxic chemotherapy is teratogenic. Effective contraception during and for 6 months after for both partners.
Monitoring?
Specialist-determined — typically FBC, renal/liver function, electrolytes before each cycle. Drug-specific tests (echocardiogram for anthracyclines, audiometry for cisplatin, etc.).
What if I miss a dose?
Oral cytotoxics: skip the missed dose, do not double up, contact your oncology team. IV: dosing is strictly scheduled — discuss any delay or missed cycle with the specialist.
Storage?
Oral cytotoxics: at room temperature, away from children, in original blister. Hand washing after handling tablets. Pregnant household members should not handle broken tablets.
Vaccines?
Live vaccines are contraindicated during chemotherapy. Inactivated vaccines (annual influenza, pneumococcal) are recommended. Coordinate with oncology for timing.
Long-term complications?
Class-dependent: secondary malignancy, infertility, cardiotoxicity, neuropathy. Discuss with oncology — fertility preservation may be relevant before starting.
When is treatment finished?
Determined by tumour response, treatment intent (curative vs palliative), and toxicity. Imaging and clinical assessment guide ongoing therapy.
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| Ισχύς | 10 mg |
|---|---|
| Ποσότητα | 100 Capsule/s, 200 Capsule/s, 300 Capsule/s |
| Pharma Form | Soft Gelatin Capsules |
| Manufacturer | Jenome Biophar |
| Treatment | Acute promyelocytic leukemia |
| Generic Brand | Tretinoin (All-trans Retinoic Acid) |
Ca Atra
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Ca Atra
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