Cb-Lin
✅ Prolactin level normalization
✅ Menstrual cycle regulation
✅ Enhanced fertility support
✅ Breast milk reduction
Cb-Lin contains Cabergoline
✓ Ιατρικά ελεγμένο από Morgan Ellis — Ερευνητής Φαρμακευτικής · 8 χρόνια εμπειρία · Τελευταία αναθεώρηση: Μάιος 2026
💡 Quick Answer
Cb-Lin is cabergoline 0.5 mg, a long-acting dopamine D2 receptor agonist. Primary uses: hyperprolactinemia and prolactinomas, suppression of lactation postpartum, and adjunct in Parkinson’s disease. Taken twice weekly — dopamine agonists have characteristic impulse-control side effects (pathological gambling, hypersexuality) that both patient and partner should know to watch for.
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What Is Cb-Lin?
Cb-Lin is a branded generic of cabergoline 0.5 mg, a highly selective long-acting dopamine D2 receptor agonist. Cabergoline suppresses prolactin secretion from the anterior pituitary by mimicking dopamine’s natural inhibitory effect on lactotroph cells.
Manufactured by Lupin. Its twice-weekly dosing schedule (compared to 2–3 times daily for bromocriptine) and better side-effect profile have made it the preferred dopamine agonist for most prolactin-related indications.
Clinical Uses
- Hyperprolactinemia — elevated prolactin of any cause; restores menstrual cycles, treats galactorrhoea, restores fertility.
- Prolactinoma (pituitary prolactin-secreting tumour) — shrinks micro- and macroadenomas; often the first-line therapy, avoiding surgery.
- Suppression of postpartum lactation — single 1 mg dose within 24 hours after delivery (historically used when breastfeeding is contraindicated or stopped).
- Parkinson’s disease adjunct — in combination with levodopa (off-label/legacy use; other agonists now preferred).
- Acromegaly — occasionally used off-label in combination with somatostatin analogues.
How to Take
- Hyperprolactinemia/prolactinoma: start at 0.25 mg twice weekly (e.g. Monday and Thursday evenings). Escalate monthly by 0.25–0.5 mg/week to 0.5–1 mg twice weekly based on prolactin response.
- Postpartum lactation suppression: single 1 mg dose within 24 hours of delivery.
- Take at bedtime with food to reduce nausea.
- Monitor prolactin every 1–3 months initially; dose-adjust to target (normalisation of prolactin).
- Once prolactin is normalised and tumour is shrunk, gradual dose reduction or even discontinuation after 2+ years may be possible (assess with specialist).
Impulse-Control Disorders — Know the Risk
All dopamine agonists (cabergoline, bromocriptine, pramipexole, ropinirole) carry a documented risk of impulse-control disorders — pathological gambling, hypersexuality, compulsive shopping, and binge eating. Onset is insidious; patients often do not notice the behaviour change themselves. Family members and partners should know to watch for:
- New gambling behaviour (online, casino, lottery) that feels out of character
- Significant changes in sexual behaviour or frequency
- Excessive shopping or purchasing behaviour
- Binge eating, particularly of specific foods
If impulse-control changes occur, reduce the dose or stop under clinical supervision — behaviours usually reverse with dose reduction.
Side Effects
Common (≥1%): nausea, headache, dizziness, orthostatic hypotension, constipation, fatigue. Most resolve with dose titration and bedtime dosing.
Less common: breast pain, hot flushes, mood changes (depression, anxiety), rhinitis.
Rare but serious: impulse-control disorders (see above), cardiac valvulopathy (particularly with cumulative doses >3 g), pulmonary fibrosis, sudden sleep onset.
Who Should Not Take Cb-Lin
- History of cardiac valve disorders (tricuspid, mitral, aortic valvulopathy)
- Severe hypertension or hypertensive disorders of pregnancy
- Known hypersensitivity to ergot alkaloids
- Pulmonary fibrosis or retroperitoneal fibrosis history
- Postpartum women with cardiovascular disorders
- Severe liver impairment
Storage
Store at room temperature (below 25 °C / 77 °F). Keep in original blister to protect from moisture. Keep out of reach of children.
Συχνές Ερωτήσεις
How fast does cabergoline lower prolactin?
Prolactin typically drops 50–80% within 2–3 weeks; normalisation takes 1–3 months. Tumour shrinkage (for prolactinomas) is seen on MRI at 3–6 months.
Can I get pregnant on cabergoline?
Yes — cabergoline often restores ovulation and fertility in women with hyperprolactinemia. For planned pregnancy, cabergoline is typically stopped once pregnancy is confirmed (except in some macroprolactinoma cases where continuation is required).
What if I miss a dose?
Take it as soon as you remember unless the next dose is within 24 hours. With twice-weekly dosing, missing a single dose is unlikely to affect prolactin control significantly.
Does cabergoline affect driving?
Cabergoline can cause sudden sleep onset and dizziness, particularly during dose escalation. Use caution driving or operating machinery until your response to the drug is stable.
Can cabergoline cause heart-valve problems?
At doses used for prolactinoma (typically ≤3 mg/week cumulative), the valvulopathy risk is low. At higher doses used for Parkinson’s (up to 4.5 mg/day), the risk is clinically significant. Annual echocardiograms may be recommended for long-term high-dose users.
How long do I need to take cabergoline?
For prolactinoma: typically until prolactin is normalised and tumour is significantly reduced on imaging (often 2+ years), then a trial of discontinuation. Some women need lifelong treatment; others can stop successfully. Guided by a specialist endocrinologist.
What does the impulse-control warning mean in practice?
Some patients on dopamine agonists develop gambling, compulsive shopping, hypersexuality, or binge eating they wouldn’t normally engage in. Behaviours are typically subtle at first. Family vigilance is important — dose reduction usually resolves the issue.
Can I drink alcohol with cabergoline?
Moderate alcohol is generally acceptable. Heavy alcohol use can amplify nausea, dizziness, and hypotension — best avoided especially during dose escalation.
Related Hormone & Women’s Health Products
- Premarin (Conjugated Estrogens)
- Premarin Cream (Vaginal Estrogen)
- Progynova (Estradiol Valerate)
- Endogest (Progesterone 100 mg)
- Gestoford (Progesterone 100 mg)
- Gestheal (Progesterone 200 mg)
- Susten Capsule (Progesterone)
⚕️ Medical Disclaimer: Information is educational and does not replace medical advice. Hormone therapies carry specific risks (breast cancer, VTE, stroke, endometrial cancer if unopposed estrogen) — consult a clinician before starting, stopping, or changing any hormone medication. Individual risk–benefit depends on personal and family medical history.
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| Ισχύς | 0.5 mg |
|---|---|
| Ποσότητα | 12 Tablet/s, 24 Tablet/s, 36 Tablet/s |
| Pharma Form | Tablet/s |
| Manufacturer | Serum Institute |
| Treatment | Increased prolactin levels, Acromegaly |
| Generic Brand | Danazol |
Cb-Lin
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