Danogen
✅ Hormone level regulation
✅ Endometriosis symptom relief
✅ Fibrocystic breast disease management
✅ Hereditary angioedema symptom relief
✅ Enhanced quality of life
Danogen contains Danazol
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
💡 Quick Answer
Danogen is danazol 50 mg, an androgen-derivative that suppresses pituitary gonadotropins (FSH, LH) and has weak androgenic + anti-estrogenic activity. Primary uses: endometriosis (historical; now less commonly used due to side effects), fibrocystic breast disease (severe), and hereditary angioedema (HAE) prophylaxis. Not used for menopausal HRT. Characteristic androgenic side effects (voice deepening — sometimes permanent, acne, weight gain, hirsutism) require strict risk-benefit discussion.
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What Is Danogen?
Danogen is a branded generic of danazol 50 mg, a synthetic steroid derived from 17-alpha-ethinyl testosterone. It is a weak androgen with anti-gonadotropin, anti-progestin, and anti-estrogen activity. By suppressing hypothalamic-pituitary-ovarian output, it induces a low-estrogen state that shrinks endometriotic implants, relieves fibrocystic breast symptoms, and reduces HAE attacks. Manufactured by German Remedies.
Category note: while this product appears in the HRT category, danazol is not menopausal hormone replacement. Its use is limited to specific gynaecologic and allergic conditions. Modern practice often prefers GnRH agonists (leuprolide), combined contraceptives, or levonorgestrel IUDs over danazol for endometriosis due to side-effect burden.
Clinical Uses
- Endometriosis: 200–800 mg/day divided (historic first-line; now less used due to side effects).
- Fibrocystic breast disease — moderate to severe pain: 100–400 mg/day.
- Hereditary angioedema (HAE) prophylaxis: 200 mg 2–3 times daily, titrating down to the lowest effective dose.
- Idiopathic thrombocytopenic purpura (ITP) adjunct (off-label, niche).
- Premature ventricular contractions and other limited indications.
How to Take
- Swallow capsules whole with water, at the same time each day, with food to reduce GI upset.
- Endometriosis: start with 400 mg/day divided, typically on day 1 of the period. Typical course: 3–6 months (not to exceed 9 months).
- Fibrocystic breast: 100–400 mg/day; continue for 4–6 months, tapering at symptom resolution.
- HAE prophylaxis: 200 mg 2–3 times daily, titrating down over months to minimum effective dose.
- Use non-hormonal contraception during treatment — danazol can cause masculinisation of female fetuses.
Side Effects (Significant)
Androgenic (common): acne, oily skin, hirsutism (facial/body hair), voice deepening (may be permanent), clitoromegaly, weight gain, mild body-shape changes.
Anti-estrogenic (common): amenorrhoea, hot flushes, vaginal dryness, reduced breast size.
Less common: mood changes, fluid retention, muscle cramps, insomnia, headache.
Serious (rare): cholestatic jaundice, hepatic adenoma, hepatocellular carcinoma (with long-term high-dose use), VTE, benign intracranial hypertension, masculinisation of female fetus (teratogenic).
Who Should Not Take Danogen
- Pregnancy — strictly contraindicated (teratogenic, masculinises female fetus)
- Active liver, kidney, or cardiac disease
- Undiagnosed vaginal bleeding
- Porphyria
- Androgen-dependent tumour history
- Known hypersensitivity
- Existing virilization or voice changes — may worsen permanently
Drug Interactions
- Warfarin: danazol raises warfarin effect — monitor INR closely.
- Carbamazepine, cyclosporine, tacrolimus, sirolimus: danazol raises their plasma levels.
- Statins (simvastatin, atorvastatin): raised statin levels, increased rhabdomyolysis risk.
- Insulin and oral hypoglycaemics: danazol can affect glucose control.
Storage
Store at room temperature (15–30 °C / 59–86 °F). Keep in original blister, away from moisture and light. Keep out of reach of children.
Frequently Asked Questions
Is voice deepening on danazol permanent?
Often yes, particularly with higher doses or longer duration. Even mild voice changes may not fully reverse after stopping. This is the single most concerning side effect for many women. Monitor voice frequently — if you notice changes, stop and discuss with a clinician.
Is danazol first-line for endometriosis?
No longer. Modern first-line options are combined hormonal contraceptives, levonorgestrel IUD, and GnRH agonists (leuprolide). Danazol is a historic option reserved for cases where other approaches have failed or are contraindicated.
How long can I take danazol?
Endometriosis: 3–6 months (up to 9). Fibrocystic breast: 4–6 months. HAE prophylaxis: long-term possible with dose minimization. Annual liver function monitoring is advised for long-term use.
Can I get pregnant on danazol?
No — contraception is required. Danazol is teratogenic. Use non-hormonal contraception (barrier methods) during treatment and for 1 cycle after stopping.
What is HAE and how does danazol help?
Hereditary angioedema — a genetic disorder with episodic severe swelling attacks (often of the face, airway, or abdomen). Danazol increases hepatic synthesis of C1 esterase inhibitor, reducing attack frequency. It’s used in selected HAE patients with contraindications or inadequate response to modern therapies (ecallantide, lanadelumab).
Can I take danazol with warfarin?
Only with very close INR monitoring. Danazol significantly raises warfarin levels. Your anticoagulation clinic may reduce warfarin dose substantially.
Will danazol cause weight gain?
~30–50% of users report weight gain (1–5 kg typical). Exercise and dietary measures help; weight usually returns to baseline within 3–6 months of stopping.
What happens if I stop danazol abruptly?
No withdrawal syndrome, but the underlying condition (endometriosis, fibrocystic disease, HAE) will recur. Consider a taper when stopping HAE prophylaxis to maintain control.
Related Hormone & Women’s Health Products
- Premarin (Conjugated Estrogens)
- Premarin Cream (Vaginal Estrogen)
- Progynova (Estradiol Valerate)
- Endogest (Progesterone 100 mg)
- Gestoford (Progesterone 100 mg)
- Gestheal (Progesterone 200 mg)
- Susten Capsule (Progesterone)
⚕️ Medical Disclaimer: Information is educational and does not replace medical advice. Hormone therapies carry specific risks (breast cancer, VTE, stroke, endometrial cancer if unopposed estrogen) — consult a clinician before starting, stopping, or changing any hormone medication. Individual risk–benefit depends on personal and family medical history.
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| Strength | 50 mg, 100 mg, 200 mg |
|---|---|
| Quantity | 30 Capsule/s, 60 Capsule/s, 90 Capsule/s |
| Pharma Form | Tablet/s |
| Manufacturer | Cipla Inc |
| Treatment | Heavy menstrual bleeding, Endometriosis, fibrocystic breasts |
| Generic Brand | Medroxyprogesterone |
Danogen
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