Cefoprox
✅ Fights bacterial infections
✅ Enhances immune response
✅ Quick relief action
✅ Low side effects
✅ Easy oral administration
✓ Ιατρικά ελεγμένο από Morgan Ellis — Ερευνητής Φαρμακευτικής · 8 χρόνια εμπειρία · Τελευταία αναθεώρηση: Μάιος 2026
⚡ Quick Answer — What is Cefoprox?
Cefoprox is a cefpodoxime proxetil tablet (100 mg / 200 mg, Mankind) — a third-generation oral cephalosporin. It has broader Gram-negative cover than cefuroxime and is used for community-acquired pneumonia, acute bacterial sinusitis, and complicated UTI. Take with food for best absorption.
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How Cefoprox works
Cefoprox contains Cefpodoxime proxetil, a third-generation cephalosporin with strong Gram-negative activity (including many Enterobacteriaceae, Neisseria spp., and Haemophilus influenzae) and good CNS penetration. Streptococcal activity is preserved; staphylococcal activity is weaker than first-generation agents. It is bactericidal via cell-wall inhibition. Resistance arises through extended-spectrum beta-lactamases (ESBLs), AmpC, and reduced porin permeability — none of these cephalosporins should be used empirically when ESBL/AmpC organisms are likely.
Indications & dosing
| Indication | Standard dose | Διάρκεια |
|---|---|---|
| Mild–moderate community-acquired pneumonia | 200 mg twice daily | 7 ημέρες |
| Acute bacterial sinusitis | 100–200 mg twice daily | 5 days |
| Uncomplicated gonorrhoea (cefixime alternative — confirm local resistance) | 400 mg single dose plus azithromycin | Single dose |
| Uncomplicated UTI (sensitive) | 200 mg twice daily | 7 ημέρες |
| Typhoid fever (cefixime, sensitive isolate) | 400 mg twice daily | 14 days |
Renal dose adjustment: all oral cephalosporins require dose extension below CrCl 30 — confirm with a clinical pharmacist for severe renal impairment. Ceftriaxone (which is biliary-excreted) does NOT need renal adjustment.
Side effects
- GI: nausea, diarrhoea (5–10%); higher with cefixime and cefpodoxime than with cephalexin.
- Hypersensitivity: 5–10% cross-reactivity with penicillin allergies (lower than once thought; ~0–2% with non-anaphylactic penicillin reactions).
- Clostridioides difficile colitis: elevated risk versus narrow-spectrum agents — broad cephalosporins are the second-most C. difficile-driving class after fluoroquinolones.
- Haematological: rarely eosinophilia, thrombocytosis, neutropenia.
- Renal: rare interstitial nephritis; dose-dependent rises in serum creatinine reported with high-dose IV cephalosporins.
- Ceftriaxone-specific: biliary pseudolithiasis (gallbladder sludge) — usually asymptomatic, reverses on stopping.
Contraindications
- Previous IgE-mediated cephalosporin allergy.
- Anaphylactic-class penicillin allergy without skin-test clearance.
- Severe renal impairment without dose adjustment (oral cephalosporins).
- Neonates with hyperbilirubinaemia — ceftriaxone displaces bilirubin from albumin (kernicterus risk).
Drug interactions
| Drug | Effect | Action |
|---|---|---|
| Warfarin | Slight INR rise (especially with N-methylthiotetrazole-side-chain cephalosporins) | Check INR mid-course |
| Calcium IV (neonates) | Lethal precipitation with ceftriaxone | Absolute contraindication ≤ 28 days |
| Προβενεσίδη | Raises serum levels (oral cephalosporins) | No routine adjustment |
| Antacids / H2 blockers | Reduces absorption of cefpodoxime | Separate by 2 hours |
| Aminoglycosides | Possible additive nephrotoxicity (high-dose IV) | Monitor renal function |
Pregnancy & Breastfeeding
Cephalosporins are FDA category B — extensively used in pregnancy without evidence of fetal harm. They are first-line alternatives in penicillin-allergic patients without an anaphylactic history.
Storage
Store below 25 °C, away from direct sunlight and moisture. Keep in original packaging. Keep out of reach of children. Discard any unused tablets after the printed expiry date — degraded antibiotics can lose potency or release breakdown products.
This medicine is only effective against bacterial infections. Do not use it for viral illnesses (common cold, most sore throats, flu, COVID-19), do not stop early when you feel better, and do not save leftovers for future infections. Misuse drives drug-resistant bacteria like MRSA, ESBL, and CRE — the WHO ranks antimicrobial resistance among the top 10 global public-health threats.
Συχνές Ερωτήσεις
Can I take Cefoprox if I am allergic to penicillin?
It depends on the type of penicillin reaction. If you had anaphylaxis, severe urticaria, angioedema, or Stevens–Johnson syndrome — avoid all beta-lactams without specialist clearance. If your reaction was a mild delayed rash, modern allergy guidance considers cephalosporin use generally safe — discuss with your prescriber.
Why do cephalosporins cause more diarrhoea than penicillins?
Cephalosporins disturb anaerobic gut flora more aggressively, particularly when poorly absorbed (cefixime is ~50% absorbed; cefpodoxime ~40%). This raises C. difficile colonisation pressure. Stop and seek review for new watery diarrhoea, especially with fever or abdominal pain.
How quickly should I feel better?
Most uncomplicated infections improve within 48–72 hours. If you are no better by day 3 — or worse — seek review. The pathogen may be resistant or the diagnosis incorrect.
Can I drink alcohol?
Most cephalosporins do not produce a disulfiram-like reaction. (Older agents like cefamandole and cefoperazone did — these are not used here.) Moderate alcohol is fine; binge drinking weakens immune response.
Should I take it with food?
Cephalexin and cefadroxil are absorbed equally with or without food. Cefpodoxime absorption is increased ~50% by food and decreased by acid suppressants — take it WITH a meal and separate from antacids by 2 hours.
What if I miss a dose?
Take it as soon as you remember. If close to the next scheduled dose, skip the missed one and resume. Never double up.
Can I use Cefoprox for a viral cold?
No — cephalosporins are bactericidal and have no activity against viruses. Inappropriate use accelerates resistance and disturbs your gut and respiratory flora. Use only for confirmed bacterial infections.
Will Cefoprox cover Pseudomonas?
No — only ceftazidime and cefepime among cephalosporins have reliable Pseudomonas activity, and neither is used here. Cefpodoxime proxetil should not be used empirically when Pseudomonas is suspected.
Will it interact with my warfarin?
Yes — INR may rise. Check INR 3–5 days into therapy and counsel on bleeding signs. Adjust warfarin dose only on physician advice.
Are cephalosporins safe in breastfeeding?
Yes — milk transfer is minimal. WHO and AAP rate cephalosporins as compatible with breastfeeding. Watch the infant for thrush or diarrhoea, but no maternal dose change is needed.
Other Antibiotics & Anti-Infective Medications
- Augmentin (Amoxicillin + Clavulanic acid) — beta-lactam alternative
- Azee (Azithromycin) — atypical-pathogen cover
- Levomac (Levofloxacin) — respiratory fluoroquinolone
- Doxt (Doxycycline) — atypical pneumonia / STIs
- Mox (Amoxicillin) — first-line for many community infections
More options in Antibiotics
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| Ισχύς | 100 mg, 200 mg |
|---|---|
| Ποσότητα | 30 Tablet/s, 60 Tablet/s, 90 Tablet/s |
| Pharma Form | Tablet/s |
| Manufacturer | Cipla Inc |
| Treatment | Bacterial infections |
| Generic Brand | Cefpodoxime |
Cefoprox
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Cefoprox
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