Daonil

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What Is Daonil?

Daonil is an oral antidiabetic medicine containing glibenclamide (also called glyburide in the United States) (5 mg), manufactured by Sanofi India Ltd. It is prescribed for adults with type 2 diabetes mellitus, usually added to metformin when glycaemic targets are not met on metformin alone. Available in packs of 30, 60, 90 or 180 tablets.

How Does Daonil Work?

Glibenclamide closes ATP-sensitive potassium channels on pancreatic beta cells, triggering insulin release. It binds both the 140 kDa (SUR1) and 65 kDa receptor sites, and binding is prolonged — this gives it a strong glucose-lowering effect but the highest hypoglycaemia risk of the commonly used sulfonylureas.

Duration of action: Once-daily dosing; half-life ~10 hours but with active metabolites giving effective duration of 18–24 hours. Sulfonylureas are most effective when there is still meaningful endogenous insulin production — that is, in early to mid-stage type 2 diabetes. They become less effective as beta-cell function declines over years.

Expected HbA1c reduction as monotherapy: 1.0–2.0 percentage points. Fasting glucose usually falls within 3–7 days.

Dosage and Administration

Starting dose: 2.5 mg once daily with breakfast. Titrate in 2.5 mg increments weekly. Usual maintenance: 5–10 mg/day; doses above 10 mg are split morning and evening. Maximum: 20 mg/day.

• Timing is critical. Always take with or immediately before the first main meal of the day. Taking on an empty stomach or without eating afterwards causes hypoglycaemia.
• Do not double up. If you miss a dose, skip it — take the next scheduled dose with your next meal.
• Self-monitor glucose. Particularly in the first 2–4 weeks, when titrating, or after any illness.
• Carry glucose tablets or a sugary snack. Sulfonylureas can cause hypoglycaemia hours after the last dose.

Side Effects

Common:

• Hypoglycaemia — the main risk. Symptoms: shakiness, sweating, palpitations, hunger, confusion, headache. Treat with 15 g fast-acting carbohydrate (glucose tablets, juice), then a snack containing complex carbohydrate.
• Weight gain — 1–3 kg on average, due to insulin-mediated anabolic effects.
• Nausea, mild GI upset
• Skin rash (typically early, occasionally photosensitivity)

Uncommon but important:

• Severe or prolonged hypoglycaemia — especially in older adults, renal impairment, missed meals, or drug interactions
• Hyponatraemia (rare)
• Haemolytic anaemia in G6PD deficiency (rare)
• Cholestatic jaundice (rare)

Αλληλεπιδράσεις Φαρμάκων

Increase hypoglycaemia risk (raise glibenclamide (also called glyburide in the United States) levels or add glucose-lowering effect):

• Insulin, meglitinides, other diabetes medicines
• Alcohol (particularly binge or without food)
• Trimethoprim/sulfamethoxazole, fluconazole, clarithromycin
• Non-selective beta-blockers (also mask hypoglycaemia symptoms)
• ACE inhibitors, salicylates in high doses
• MAO inhibitors, fibrates

Reduce glucose-lowering effect:

• Corticosteroids, oral contraceptives, thiazide diuretics, thyroid hormones, phenytoin, rifampicin, atypical antipsychotics

Who Should Not Take Daonil?

• Type 1 diabetes mellitus
• Diabetic ketoacidosis (DKA), with or without coma
• Severe renal impairment — Avoid in moderate-to-severe renal impairment (eGFR < 60). Active metabolites accumulate and cause prolonged, severe hypoglycaemia.
• Severe hepatic impairment
• Known sulfonamide (sulfa) allergy
• Pregnancy — sulfonylureas are not first choice in pregnancy (insulin preferred)
• Breastfeeding — limited data; avoid
• G6PD deficiency (relative contraindication)

In older adults (> 65 years): start at half the usual dose and titrate slowly — hypoglycaemia risk and consequences are higher.

Storage

Store Daonil below 25°C in a dry place, in the original blister. Keep out of reach of children.

Συχνές Ερωτήσεις

Is Daonil the same as glibenclamide (also called glyburide in the United States)?

Yes. Daonil is a brand of glibenclamide (also called glyburide in the United States) manufactured by Sanofi India Ltd. Bioequivalence is required by regulatory authorities, so clinical effect is the same as the originator brand at the same dose.

Is glibenclamide the same as glyburide?

Yes — glibenclamide (international non-proprietary name, INN) and glyburide (United States Adopted Name, USAN) are the same drug. Generic manufacturers in different regions label it differently.

Can Daonil cause weight gain?

Yes — sulfonylureas typically cause 1–3 kg weight gain over the first year. This is partly because insulin is an anabolic hormone, and partly because people eat extra snacks to prevent hypoglycaemia. If weight gain is a concern, a DPP-4 inhibitor or SGLT-2 inhibitor may be preferred instead.

What should I do if I have a hypo?

Take 15 g of fast-acting carbohydrate immediately — 4–5 glucose tablets, 150 mL regular juice or cola, or 1 tablespoon of honey. Recheck glucose after 15 minutes; repeat if still < 4.0 mmol/L. Follow with a snack containing complex carbohydrate (bread, biscuit) to prevent relapse. Sulfonylurea hypos can last hours — severe episodes need medical review.

Can I drink alcohol while taking Daonil?

Moderate alcohol with food is usually safe. Avoid binge drinking and avoid alcohol on an empty stomach — both dramatically raise hypoglycaemia risk. Alcohol may also worsen flushing and nausea in some people taking sulfonylureas.

Do I still need metformin if I take Daonil?

Usually, yes. Sulfonylureas are almost always used on top of metformin, not instead of it. Metformin remains first-line and works by a different mechanism (reducing hepatic glucose production), so the two medicines have additive effect.

Where can I buy Daonil online?

You can order Daonil (5 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide, with discreet packaging and genuine WHO-GMP certified manufacturer stock.

Related Diabetes Medications

• Amaryl — Glimepiride 1/2/4 mg (Sanofi)
• Glycomet SR — Metformin sustained-release
• Januvia — Sitagliptin (DPP-4 inhibitor)
• Jardiance — Empagliflozin (SGLT-2 inhibitor)
• Glucored — Glibenclamide + Metformin combo
• Glycomet-GP — Metformin + Glimepiride combo
• Browse all Diabetes Medications

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