Frontline Plus XL
✅ Effective flea control
✅ Prevents flea infestations
✅ Kills flea eggs
✅ Long-lasting protection
✅ Suitable for large dogs
Frontline Plus XL contains fipronil and methoprene.
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
Quick Answer
Frontline Plus XL is veterinary medication for use in animals only — do not self-administer to humans. Read the dosing, side-effect, and interaction sections below before use; the FAQs at the bottom cover the most common questions.
📦 Every order is covered by our Reshipment Assurance Policy — if your parcel does not arrive within 20 business days, we reship it.
Why order from MedsBase
Our generic medications are sourced from WHO-GMP certified manufacturers and shipped worldwide in discreet, plain packaging — no medication name on the parcel exterior. Card payments are routed through a regulated processor (statement descriptors include a regulated card-payment processor — never “MedsBase” or any medication name). Crypto and SEPA bank transfer are also accepted. Every order is backed by our Reshipment Assurance Policy.
Product Overview
Frontline Plus XL is a veterinarian-recommended medication specially formulated for dogs. It contains the active ingredients fipronil and (S)-methoprene, which work together to provide comprehensive protection against fleas, ticks, and their larvae and eggs. Frontline Plus XL comes in convenient pipettes for easy topical application, making it a reliable choice for pet owners seeking long-lasting flea and tick control for their furry companions.
Uses
Frontline Plus XL is used to effectively prevent and treat flea and tick infestations in dogs. It kills adult fleas, flea eggs, flea larvae, ticks, and chewing lice, providing both immediate relief and long-term protection. Frontline Plus XL can help alleviate itching and discomfort caused by flea bites, as well as reduce the risk of tick-borne diseases such as Lyme disease and Rocky Mountain spotted fever.
How to Use
To use Frontline Plus XL, simply remove one pipette from the package and hold it upright. Tap the narrow part of the pipette to ensure the contents are in the main body of the pipette. Snap off the tip along the scored line to open the pipette, and part the fur between your dog’s shoulder blades to expose the skin. Apply the entire contents of the pipette directly onto the skin, making sure to avoid contact with your dog’s eyes or mouth. Repeat the application monthly for continuous protection.
How it Works
Frontline Plus XL works by targeting the nervous systems of fleas and ticks upon contact. The active ingredient fipronil disrupts the normal functioning of insect nerve cells, leading to paralysis and eventual death of the pests. Additionally, (S)-methoprene acts as an insect growth regulator, preventing flea eggs and larvae from developing into adults, thus breaking the flea life cycle. This dual-action formula ensures rapid elimination of existing parasites and prevents reinfestation.
Dosage and Administration
For dogs weighing over 40kg, apply one pipette (4.02mL) of Frontline Plus XL solution directly onto the skin once a month. Ensure proper dosage by choosing the appropriate product based on your dog’s weight. Do not use Frontline Plus XL on cats or other animals, as it is formulated specifically for dogs. Consult your veterinarian for advice on the most suitable flea and tick control regimen for your pet.
Benefits
- Provides comprehensive protection against fleas, ticks, and their larvae and eggs
- Kills adult fleas, flea eggs, flea larvae, ticks, and chewing lice
- Offers both immediate relief and long-lasting prevention
- Helps alleviate itching and discomfort caused by flea bites
- Reduces the risk of tick-borne diseases in dogs
Common Side Effects
Common side effects of Frontline Plus XL may include temporary skin irritation or sensitivity at the application site. These reactions are typically mild and transient, resolving on their own without any specific treatment. However, if your dog experiences persistent irritation or other adverse effects, discontinue use and consult your veterinarian for further guidance.
Warnings
Avoid contact with eyes or mouth when applying Frontline Plus XL to your dog. Do not allow children to handle treated dogs until the application site is dry. If accidental ingestion occurs, seek medical advice immediately and bring the product label or packaging for reference. Frontline Plus XL is for external use on dogs only and should not be ingested or applied to other species. Use with caution in debilitated, aged, or pregnant animals.
Storage Information
Store Frontline Plus XL in the original packaging at room temperature, away from heat and direct sunlight. Keep out of reach of children and pets. Do not store or reuse empty pipettes. Dispose of used pipettes properly according to local regulations.
Disclaimer:
Our sole intention is to ensure that its consumers get information that is expert-reviewed, accurate, and trustworthy. However, the information contained herein should NOT be used as a substitute for the advice of a qualified veterinarian. The information provided here is for informational purposes only. This may not cover all possible side effects, drug interactions, or warnings or alerts. Please consult your veterinarian and discuss all your queries related to any pet health concerns or medicines. We intend to support, not replace, the pet owner-veterinarian relationship.
Frequently Asked Questions
How does Frontline Plus XL work?
Frontline Plus XL is a veterinary-only formulation — refer to the species, weight, and indication on the label or your veterinarian's instructions. The mechanism, dose-by-indication tables, and contraindication list above give the molecule-specific clinical detail.
How quickly does Frontline Plus XL work?
depends on the species, indication, and route — refer to the label. Read the indication-specific dosing section above for the schedule that applies to your case.
What are the most common side effects?
The side-effect profile depends on the molecule and dose. The clinical section above lists the frequent, occasional, and rare adverse effects to expect, plus the warning signs that need immediate medical review.
Can I take Frontline Plus XL with food or alcohol?
Food and alcohol interactions vary by molecule. Check the drug-interaction table above for the specific food, alcohol, and concomitant-medication rules that apply.
What should I do if I miss a dose?
Generally, take a missed dose as soon as you remember unless it is close to the next scheduled dose, in which case skip it — never double-dose. Specific molecules have specific rules; the dosing section above states whether this medication has any non-standard missed-dose handling.
Where can I order Frontline Plus XL from MedsBase?
MedsBase ships Frontline Plus XL discreetly worldwide from a WHO-GMP certified manufacturer. Card payments are processed through a regulated crypto on-ramp — your bank statement shows the processor name (a regulated card-payment processor), never “MedsBase” or any medication name. Every order is covered by our 20-business-day Reshipment Assurance.
Households already using a fipronil spot-on like Frontline Plus XL sometimes need broader cover for blowfly maggots, mange mites or open-wound infestations the spot-on cannot reach — Lorexane Spray (lindane 0.1% + propoxur antiparasitic & antiseptic spray) is the clinical follow-on for those scenarios.
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