Mirnite
Mirnite (Mirtazapine 7.5/15/30 mg) — tetracyclic NaSSA for MDD with insomnia, anxiety or weight loss. paradoxically less sedating at 30+ mg than at 15 mg.
✓ Ιατρικά ελεγμένο από Morgan Ellis — Ερευνητής Φαρμακευτικής · 8 χρόνια εμπειρία · Τελευταία αναθεώρηση: Μάιος 2026
⚡ Γρήγορη Απάντηση
Mirnite (Mirtazapine 7.5 / 15 / 30 mg) is a tetracyclic antidepressant (NaSSA) for major depression, particularly when insomnia, anxiety, weight loss, or anorexia are dominant symptoms. Strongly sedating at low doses, less sedating at higher doses (counterintuitive — see below).
📦 Κάθε παραγγελία καλύπτεται από την Πολιτική Εγγύησης Επαναποστολής — εάν το δέμα σας δεν φτάσει εντός 20 εργάσιμων ημερών, το επαναποστέλλουμε.
Γιατί να παραγγείλετε από τη MedsBase
Mirnite at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our Πολιτική Εγγύησης Επαναποστολής — παράθυρο άφιξης 20 εργάσιμων ημερών ή επαναποστολή χωρίς χρέωση — και δικαιούται συμμετοχή στο πρόγραμμα αφοσίωσης πελατών. Διατίθεται παγκόσμια αποστολή στις περισσότερες προορισμούς.
What Mirnite is and how it works
Mirnite is a 7.5 / 15 / 30 mg mirtazapine tablet supplied by Intas. Mirtazapine is structurally and mechanistically distinct from SSRIs/SNRIs/TCAs. It is a noradrenergic and specific serotonergic antidepressant (NaSSA): it blocks central α2-adrenergic autoreceptors (raising NA and 5-HT release indirectly), 5-HT2A and 5-HT2C receptors (anxiolytic, sleep-promoting, no sexual dysfunction), and H1 histamine receptors (sedation and appetite stimulation).
At 7.5–15 mg, mirtazapine is most sedating. At 30 mg+, the noradrenergic component (which is more linearly dose-related than the H1 antihistaminergic component) starts to offset the H1 sedation. Many patients describe 30 mg as “feeling more energised” than 15 mg. If a patient wants more sleep, lower the dose — not raise it.
Ενδείξεις και δοσολογία
| Ενδείξεις | Εκκίνηση | Στόχος | Μέγιστο |
|---|---|---|---|
| Μείζων κατάθλιψη | 15 mg HS | 30 mg HS | 45 mg |
| Depression with insomnia | 7.5–15 mg HS | 15 mg HS (often sufficient) | 30 mg |
| Depression with weight loss / anorexia | 15 mg HS | 30–45 mg HS | 45 mg |
| SSRI augmentation | 7.5–15 mg HS added to SSRI | 15 mg HS | 30 mg |
| Older adults | 7.5 mg HS | 15 mg HS | 30 mg |
Σημαντικές ασφαλιστικές εκτιμήσεις
Mirtazapine is one of the heaviest-weight-gain antidepressants — typical 4–7 kg over 6 months. Useful in patients with depression-related weight loss; problematic in obese or metabolic-syndrome patients. Check fasting lipids and HbA1c at 6 months.
Reversible neutropenia and rare agranulocytosis described — incidence approximately 1 in 1000. Stop immediately and check FBC if fever, sore throat, mouth ulcers, or other signs of infection appear in the first 8 weeks. Routine FBC is not required.
Mirtazapine commonly worsens restless legs syndrome and periodic limb movements of sleep — relevant in patients with prior RLS or sleep complaints.
Όλα τα αντικαταθλιπτικά φέρουν προειδοποίηση μαύρου πλαισίου από τον FDA για αυξημένη αυτοκτονική ιδέα σε ασθενείς κάτω των 25 ετών.
Συχνές παρενέργειες
- Sedation: universal at 15 mg; lessens at 30+ mg; bedtime dosing harnesses it as benefit.
- Weight gain and increased appetite: 4–7 kg typical at 6 months.
- Dry mouth: common, mild.
- Constipation: mild anticholinergic action.
- No sexual dysfunction: distinct advantage over SSRIs.
- Vivid dreams: some patients describe unusually intense dreams.
- Cholesterol / triglycerides: small mean rise.
Αλληλεπιδράσεις φαρμάκων
- MAOIs — 14-day washout each direction.
- Strong CYP3A4 inhibitors / inducers — moderate effect on mirtazapine levels.
- CNS depressants (alcohol, benzodiazepines, opioids, Z-drugs) — additive sedation.
- Other serotonergic drugs — serotonin syndrome described but uncommon (mirtazapine’s 5-HT2A antagonism is partly protective).
- Βαρφαρίνη — small INR rise; monitor.
Εγκυμοσύνη, θηλασμός, παιδιατρική
Pregnancy: limited data; weigh against untreated maternal depression. Breastfeeding: passes into milk; sometimes used in postpartum depression where insomnia and weight loss are concerns. Paediatric: not first-line.
Αποθήκευση
Αποθηκεύστε σε θερμοκρασία 15–30 °C στην αρχική συσκευασία.
Συχνές Ερωτήσεις
Why is Mirnite more sedating at 15 mg than at 30 mg?
Mirtazapine has dose-dependent effects on different receptors. At 15 mg, the H1 antihistamine action dominates — strongly sedating. At 30 mg+, the noradrenergic action ramps up and offsets the sedation. This is the opposite of intuition and is the most-asked question about mirtazapine. If your sleep is too heavy, raise the dose; if you want more sleep, lower it.
Will Mirnite make me gain weight?
Yes — typically 4–7 kg over 6 months. This is one of the most reliable side effects. In patients with depression-driven weight loss it’s a feature; in obese patients it’s a problem. Discuss this trade-off explicitly before starting.
Why is Mirnite taken at bedtime?
The H1 antihistamine sedation peaks 2–3 hours after the dose. Bedtime dosing recruits the sedation as a sleep benefit instead of daytime drowsiness. Morning dosing produces unacceptable drowsiness in most patients.
How is Mirnite different from an SSRI?
Different mechanism (α2 + 5-HT2A/2C + H1 blockade vs SERT inhibition) translates to: more sedation, more appetite, more weight gain, no sexual dysfunction, less GI upset, less anxiety surge. Useful when those SSRI side effects are problematic or when insomnia/weight loss are dominant symptoms.
Can Mirnite be combined with an SSRI?
Yes — the so-called “California rocket fuel” (SSRI/SNRI + mirtazapine) is a recognised combination for severe or partial-response depression. Mirtazapine is added typically at 7.5–15 mg HS. Specialist supervision recommended.
How long until Mirnite works?
Sleep and appetite often improve within 1–2 weeks; the mood effect builds over 4–6 weeks at 15–30 mg.
How do I stop Mirnite?
Taper over 2–4 weeks. Withdrawal is generally milder than SSRI/SNRI withdrawal but rebound insomnia and dysphoria are described.
Will Mirnite affect my driving?
Yes — the first 1–2 weeks of sedation can impair reaction time. Avoid driving until you know your tolerability. After that, most patients drive normally on stable doses.
Does Mirnite help anxiety?
Yes — the 5-HT2A and 5-HT2C antagonism contributes a meaningful anxiolytic effect, often visible within the first 1–2 weeks. Useful when depression and anxiety co-exist.
Is Mirnite addictive?
No — no euphoria, no compulsive use, no escalating tolerance. Physical dependence is mild and shorter than SSRI dependence.
Άλλα Φάρμακα Ψυχικής Υγείας
- Agoprex (Agomelatine — melatonergic)
- Flunil (Fluoxetine SSRI)
- Duvanta (Duloxetine SNRI)
- Bupron XL (Bupropion XL — NDRI)
- Lexaheal (Escitalopram SSRI)
Περισσότερες επιλογές στην Ψυχική Υγεία και Ψυχιατρικά Φάρμακα
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| Ισχύς | 7.5 mg |
|---|---|
| Ποσότητα | 30 δισκία, 60 δισκία, 90 δισκία, 180 δισκία |
Mirnite
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