Oestrogel Gel
Oestrogel Gel (transdermal estradiol 0.06% w/w) — bioidentical 17β-estradiol absorbed through the skin for menopausal HRT. Bypasses first-pass liver metabolism for lower VTE and stroke risk than oral estrogen.
✓ Ιατρικά ελεγμένο από Morgan Ellis — Ερευνητής Φαρμακευτικής · 8 χρόνια εμπειρία · Τελευταία αναθεώρηση: Μάιος 2026
💡 Quick Answer
Oestrogel Gel είναι transdermal estradiol 0.06% w/w — bioidentical 17β-estradiol absorbed through the skin for menopausal HRT. Transdermal delivery bypasses first-pass liver metabolism, giving lower VTE and stroke risk than oral estrogen. Apply once daily to the skin of the arms, shoulders, or thighs. Women with a uterus must combine with a progestin (Susten / Endogest / Naturogest / Meprate) to protect the endometrium.
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What Is Oestrogel Gel?
Oestrogel Gel is 17β-estradiol (the bioidentical estrogen produced by the ovaries) in a clear hydroalcoholic gel base, 0.06% w/w. Each pump or pre-measured strip delivers a metered dose of estradiol that absorbs through the skin into the systemic circulation. The active ingredient is identical to endogenous estradiol — not a synthetic analogue, not conjugated equine estrogens (Premarin), and not estriol or estrone.
Ενδείξεις
- Vasomotor symptoms of menopause — hot flushes, night sweats — the strongest evidence-based indication.
- Genitourinary syndrome of menopause — vaginal dryness, dyspareunia (often combined with local vaginal estrogen for resistant symptoms).
- Prevention of postmenopausal osteoporosis — evidence-supported, particularly when started early after menopause.
- Premature ovarian insufficiency / surgical menopause — physiological replacement until natural menopause age (~51).
- Mood and cognitive symptoms in early menopause (KEEPS supports a window-of-opportunity benefit).
Why Transdermal — Compared with Oral Estrogen
Oral estrogen passes through the liver first, where it raises clotting factors, sex-hormone-binding globulin, and CRP. Transdermal estradiol bypasses that first-pass step, with the following measurable consequences:
- Lower VTE risk — ESTHER and observational meta-analyses show transdermal does not raise VTE meaningfully, while oral roughly doubles it.
- Lower stroke risk at standard doses.
- Less impact on triglycerides and CRP.
- Less change to thyroid-binding globulin — useful in hypothyroid women on levothyroxine.
For these reasons, transdermal is the preferred route in women with VTE risk factors (obesity, family history, smoking history, age > 60), gallstone disease, hypertriglyceridaemia, migraine with aura, or hypothyroidism. Modern UK and European guidelines recommend transdermal as first-line for most starts.
How to Apply Oestrogel
- Δόση: typical start is one or two pumps daily (0.75–1.5 mg estradiol/day). Titrate to symptoms over 2–4 weeks; some women need three pumps.
- Apply to: a clean, dry, intact area of skin on the arms (shoulder to wrist), shoulders, upper back, or thighs — about a hand’s width.
- Do NOT apply to: breasts, vulva, broken or irritated skin, or cosmetic-product-treated skin.
- Allow to dry for 2–5 minutes before getting dressed; do not wash the area for at least 1 hour. Do not apply moisturiser, sunscreen, or perfume to the same site.
- Avoid skin-to-skin transfer — do not let children, pregnant women, or men press against the application site for 1 hour. Estradiol can be absorbed transdermally by anyone in close contact.
- Add a progestin if you have a uterus — Susten / Endogest / Naturogest 100 mg continuous daily, or 200 mg cyclic for 12–14 days/month. Without progestin opposition, estrogen alone causes endometrial hyperplasia and cancer.
Παρενέργειες
Συχνές: breast tenderness, headache, leg cramps, mild nausea, breakthrough bleeding (especially in the first 6 months), local skin irritation, mood changes.
Λιγότερο συχνές: melasma, weight changes, gallbladder symptoms (less than oral), libido change.
Serious (seek urgent care): sudden severe headache, vision changes, calf pain or swelling, chest pain, jaundice, breast lump, post-menopausal bleeding lasting more than 6 months from start.
Αντενδείξεις
- Active or past breast cancer or other estrogen-dependent cancer
- Undiagnosed vaginal bleeding
- Active or past VTE / pulmonary embolism / stroke / MI
- Severe liver disease, active hepatic adenoma
- Εγκυμοσύνη
- Migraine with aura (relative — transdermal is preferred over oral if HRT is needed)
- Known thrombophilia (Factor V Leiden, prothrombin gene mutation)
Αλληλεπιδράσεις Φαρμάκων
CYP3A4 inducers (rifampicin, carbamazepine, phenytoin, phenobarbital, St John’s wort) reduce estradiol levels and may worsen menopausal symptoms. Transdermal route is less affected by CYP than oral, but interactions still occur. Levothyroxine dose may need re-titration after starting or stopping HRT — check TSH at 6–8 weeks.
Pregnancy & Breastfeeding
Contraindicated in pregnancy and breastfeeding.
Αποθήκευση
Store below 25 °C with the cap firmly closed (the gel is alcohol-based and evaporates if left open). Keep upright. Keep out of the reach of children — transdermal estradiol can be absorbed through children’s skin in clinically significant amounts.
Συχνές Ερωτήσεις
Do I need a progestin with Oestrogel?
If you have a uterus, yes — estrogen alone causes endometrial hyperplasia and cancer. Use Susten / Endogest / Naturogest (micronized progesterone, preferred) or Meprate (MPA). If you have had a hysterectomy, no progestin is needed.
How long until I notice symptom relief?
Hot flushes typically start improving within 2–4 weeks; full benefit takes 8–12 weeks. If symptoms persist, your clinician may add a pump or switch to a higher-dose patch.
Is transdermal estrogen safer than oral?
For VTE, stroke, gallbladder, and triglyceride risk — yes, the evidence is clear. Breast cancer risk is similar between routes. Quality-of-life benefit is similar.
Can I apply Oestrogel to my breasts?
No. Application to the breasts increases local estrogen exposure of breast tissue and is associated with breast tenderness and theoretical concern. Apply to arms, shoulders, upper back, or thighs.
Will my partner / children absorb estradiol if they touch the application site?
Yes — this is real. Allow the gel to dry fully (5 minutes) and avoid skin-to-skin contact at the site for at least 1 hour. Children exposed to applied estradiol have developed precocious puberty signs.
Can I shower or swim after applying?
Wait at least 1 hour after application before showering or swimming. Apply at a time that fits your routine (usually morning).
Τι γίνεται αν χάσω μια δόση;
Apply as soon as you remember. If it is close to the next scheduled dose, skip the missed one — do not double up. Missed days can cause breakthrough symptoms.
Can I use Oestrogel after breast cancer?
Generally contraindicated. Discuss with your oncologist; non-hormonal options (SSRIs, gabapentin, clonidine, CBT) are usually preferred for vasomotor symptoms after breast cancer.
How is Oestrogel different from Premarin?
Oestrogel is bioidentical 17β-estradiol applied transdermally. Premarin is conjugated equine estrogens (a mix of estrogenic compounds derived from pregnant mare urine) taken orally. Transdermal bioidentical is the modern preferred starting point; Premarin is still effective but carries the oral first-pass profile.
Will Oestrogel help with vaginal dryness?
It helps systemically — many women improve. For resistant or severe local symptoms, add Premarin Cream (vaginal conjugated estrogens) or another local vaginal estrogen alongside Oestrogel. Local vaginal estrogen does not require progestin opposition.
Other Hormone & Women’s Health Medications
Άλλα προϊόντα σε HRT & Women’s Health που οι πελάτες εξετάζουν επίσης:
- Progynova (Estradiol Valerate Oral)
- Premarin (Conjugated Estrogens Oral)
- Premarin Cream (Vaginal Estrogen)
- Susten Capsule (Micronized Progesterone)
- Endogest (Micronized Progesterone)
⚠️ Medical Disclaimer
Hormone therapy carries individual benefit-risk trade-offs that vary by age, time-since-menopause, personal and family history, and concurrent conditions. Discuss your full medical history with a clinician before starting, switching, or stopping HRT, progestin therapy, or vaginal estrogen. Stop and seek urgent care for unexplained vaginal bleeding, sudden severe headache, vision changes, calf pain or swelling, chest pain, or breast lump.
More options in Hormone Replacement Therapy (HRT) Medication for Menopause
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| Ισχύς | 0.06% |
|---|---|
| Ποσότητα | 1 Tube/s, 3 Tube/s, 6 Tablet/s |
| Φαρμακευτική Μορφή | Tube/s |
| Κατασκευαστής | Besins Healthcare |
| Θεραπεία | Menopausal HRT, vasomotor symptoms, osteoporosis prevention |
| Γενόσημη μάρκα | Estradiol (Transdermal) |
Oestrogel Gel
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Oestrogel Gel
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