Levolin Inhaler
✅ Fast asthma symptom relief
✅ Convenient inhalation option
✅ Targeted medication delivery
✅ COPD symptom control
contains Levosalbutamol
✓ Medically reviewed by Morgan Ellis — Pharmacy Researcher · 8 years experience · Last reviewed: May 2026
⚡ Quick Answer — What is Levolin Inhaler?
Levolin Inhaler contains levosalbutamol — the active R-isomer of salbutamol, a short-acting beta-2 agonist (SABA) that relaxes bronchial smooth muscle to relieve breathlessness, wheezing, and chest tightness in asthma and chronic obstructive pulmonary disease (COPD). Levolin Inhaler is a pressurised metered-dose inhaler (HFA pMDI) from Cipla. Onset of bronchodilation is 1–5 minutes and effect lasts 4–6 hours. Levosalbutamol delivers similar bronchodilation to salbutamol at half the dose, with potentially fewer cardiac side-effects (tremor, tachycardia) — useful for patients sensitive to standard salbutamol.
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What Is Levolin Inhaler?
Levolin Inhaler is a pressurised metered-dose inhaler (HFA pMDI) manufactured by Cipla at WHO-GMP certified facilities. Each inhaler delivers 50 mcg per actuation of levosalbutamol. levosalbutamol is on the WHO List of Essential Medicines and is the world’s most-used reliever medication for asthma and reversible airflow obstruction.
Levosalbutamol is the pharmacologically active R-(−)-enantiomer of salbutamol. Standard salbutamol is a 50:50 racemic mixture of R and S isomers; the S-isomer contributes nothing to bronchodilation but may worsen airway hyperreactivity in some patients. By using only the R-isomer, levosalbutamol delivers the same therapeutic effect at half the milligram dose, with potentially less tremor and tachycardia in sensitive patients (especially children and those with cardiovascular comorbidities).
How Does Levolin Inhaler Work?
levosalbutamol selectively activates beta-2 adrenergic receptors on the smooth muscle that rings the bronchial airways. Receptor activation raises intracellular cyclic AMP, smooth muscle relaxes, and the airway lumen widens — this is bronchodilation. Bronchodilation begins within 1–5 minutes, peaks at 30–90 minutes, and lasts 4–6 hours. levosalbutamol also modestly inhibits mast-cell mediator release, reduces plasma exudation from airway capillaries, and improves mucociliary clearance.
Selectivity is dose-dependent: at therapeutic doses, β2 effects predominate; at higher systemic doses (oral tablets, repeated nebulisation), spillover onto β1 receptors causes tachycardia and palpitations, and onto β2 receptors elsewhere causes tremor and hypokalaemia.
Uses and Indications
- Acute asthma exacerbations — first-line reliever (rescue) inhaler/nebulisation
- Chronic obstructive pulmonary disease (COPD) — symptomatic relief of acute breathlessness and exercise dyspnoea
- Exercise-induced bronchoconstriction — inhaled 15–30 minutes before exercise
- Bronchospasm with allergen, cold air, or viral exposure
- Anaphylaxis with bronchospasm — adjunct to adrenaline
- Hyperkalaemia (off-label) — nebulised salbutamol drives K⁺ intracellularly
Important: Levolin Inhaler is a reliever, not a controller. It does not reduce underlying airway inflammation. Patients using more than the equivalent of one SABA canister per month, or needing a SABA more than three days per week outside of exercise pre-dosing, have poorly-controlled asthma and require step-up to inhaled corticosteroid (ICS) or ICS-LABA combination therapy.
Levolin Inhaler Dosage
| Indication | Dose | Frequency |
|---|---|---|
| Acute reliever (adult) | 50–100 mcg (1–2 puffs) | Every 4–6 hours as needed |
| Pre-exercise | 50–100 mcg | 15 minutes before exercise |
| Children 6–11 yr | 50 mcg (1 puff) | Every 4–6 hours as needed |
| Severe attack | 200 mcg via spacer | Every 20 minutes ×3, then reassess |
How to Use Levolin Inhaler Properly
- Shake well; remove the cap.
- Breathe out fully away from the inhaler.
- Seal lips around the mouthpiece.
- Press the canister as you start a slow deep breath (3–5 seconds).
- Hold breath 10 seconds, then breathe out through the nose.
- Wait 30 seconds before a second puff.
- Use a spacer for children, the elderly, or anyone with poor coordination.
Side Effects of Levolin Inhaler
Common (dose-related, settle within 30–60 minutes):
- Fine tremor, especially of the hands
- Palpitations or increased heart rate (typically 10–20 bpm rise)
- Headache
- Dry mouth, throat irritation (more common with DPI/MDI)
- Muscle cramps
- Hyperactivity or agitation in young children
Less common:
- Hypokalaemia — especially with high repeat doses, worsened by theophylline, steroids or loop diuretics
- Mild hyperglycaemia
- Insomnia if dosed late evening
- Possible paradoxical worsening with the R-isomer is rare
Serious (stop and seek emergency help):
- Severe allergic reaction / angio-oedema / anaphylaxis
- Paradoxical bronchospasm — worsening wheeze immediately after dose
- Cardiac arrhythmias (atrial fibrillation, supraventricular tachycardia)
- Severe hypokalaemia with arrhythmia or muscle weakness
Warnings and Precautions
- Frequent {$brand} use = poor asthma control. Needing a reliever more than 3 days per week (excluding exercise pre-dosing) means the underlying disease is not managed. Step up ICS-based controller therapy.
- Carry your reliever with you — many fatal asthma attacks happen when the inhaler is at home or expired.
- Cardiovascular disease: use cautiously in severe coronary artery disease, arrhythmias, hyperthyroidism, or severe heart failure.
- Diabetes: monitor glucose with repeat high doses.
- Pregnancy and breastfeeding: levosalbutamol is used at the lowest effective dose. Uncontrolled asthma is more dangerous to mother and fetus than the drug itself.
- Severe attack red flags (call emergency services): no relief 10 min after a full dose, peak flow <50% of personal best, difficulty speaking in full sentences, blue lips or drowsiness.
Contraindications
- Known hypersensitivity to levosalbutamol or any formulation excipient
- Tachyarrhythmias (uncontrolled) — relative contraindication
- Phaeochromocytoma — relative contraindication
- Hypertrophic obstructive cardiomyopathy — caution
Drug Interactions
| Interacting drug | Effect | What to do |
|---|---|---|
| Non-selective beta-blockers (propranolol, timolol drops) | Block β2 effect — can precipitate severe bronchospasm | Avoid; switch to cardioselective beta-blocker if essential |
| Loop or thiazide diuretics | Additive hypokalaemia | Monitor serum potassium with high doses |
| Systemic corticosteroids | Additive hypokalaemia + hyperglycaemia | Monitor electrolytes and glucose |
| Theophylline / aminophylline | Additive tachycardia and hypokalaemia | Monitor heart rate and potassium |
| MAOIs and tricyclic antidepressants | Potentiate cardiovascular effects | Caution — monitor BP/HR |
| Digoxin | Hypokalaemia increases digoxin toxicity risk | Monitor potassium; check digoxin level if symptomatic |
Storage
- Store below 25°C, protected from direct sunlight and heat.
- Do not refrigerate. Do not freeze.
- Do not puncture the canister; even an empty canister can explode if heated.
- Keep out of reach of children. Use within the expiry date printed on the canister.
Related Alternatives on MedsBase
- Asthalin Respules — salbutamol nebuliser solution
- Budecort Inhaler — budesonide ICS preventer
- Foracort Inhaler — budesonide + formoterol ICS-LABA
- Seretide Accuhaler — fluticasone + salmeterol ICS-LABA
- Duolin Inhaler — salbutamol + ipratropium combo reliever
Frequently Asked Questions
How is Levolin Inhaler different from Asthalin Inhaler?
Asthalin = salbutamol 100 mcg per puff (racemic mixture). Levolin = levosalbutamol 50 mcg per puff (active R-isomer only). Clinically equivalent at half the milligram dose. Some patients report less tremor and palpitations on Levolin.
How many puffs of Levolin can I take?
Routine: 1–2 puffs every 4–6 hours, max 8 puffs (400 mcg) per day. Severe attack: 4–10 puffs via spacer under supervision.
Can children use Levolin Inhaler?
Yes, from age 4–6 with a spacer + mask, or from age 6 with a spacer + mouthpiece.
Is Levolin Inhaler safer than Asthalin Inhaler?
In some patient groups (children, those with cardiac comorbidities, those who report tremor on salbutamol), levosalbutamol may have a marginally better tolerability profile. For most adults the difference is small.
Should I use a spacer?
A spacer is strongly recommended for children, the elderly, anyone with arthritis or coordination problems, and in any acute attack. It improves drug delivery 2–3× and removes the need to time breath with actuation.
How fast should I inhale?
Slow and deep over 3–5 seconds (this is the MDI rule — opposite of DPI rotacaps which need a fast inhalation).
Why is my mouth dry?
Local deposition on the oropharynx is normal. A spacer reduces it. Rinsing mouth after use helps.
Can I take Levolin Inhaler with a beta-blocker?
Cardioselective beta-blockers (bisoprolol, atenolol) are usually OK; non-selective (propranolol) and timolol eye drops should be avoided where possible.
How long does the canister last?
A 200-puff canister lasts about 100 days at 2 puffs/day. Track usage or check the dose counter if fitted.
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| Strength | 50 mcg |
|---|---|
| Quantity | 1 Inhaler/s, 3 Inhaler/s, 6 Inhaler/s |
| Pharma Form | Tablet/s |
| Manufacturer | Cipla Inc |
| Treatment | Asthma, Chronic obstructive pulmonary disorder (COPD) |
| Generic Brand | Levosalbutamol |
Levolin Inhaler
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Levolin Inhaler
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